Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway DOI Creative Commons
Hui Shen,

hongxia li,

wenlan pan

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Abstract Background: Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms underlie this phenomenon have yet to be extensively investigated. Methods: The Morris water maze test was utilized assess performance. RNA sequencing employed discover primary regulators and pathological pathways involved in impairment caused by heat. Prior heat vivo vitro, activation of sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) achieved CDN1163. Hematoxylin-Eosin, Nissl staining, imaging, transmission electron microscopy, western blot immunofluorescence were visualize histological changes, intracellular levels, endoplasmic stress (ERS) markers, apoptosis, synaptic proteins alterations. Results: (HS) significantly induced decline neuronal damage mice. By transcriptome between control (n=5) mice hippocampal tissues, we identified a reduction expression atp2a gene encoding SERCA, accompanied corresponding decrease its protein level. Consequently, dysregulation resulted excessive accumulation ions. Furthermore, HS also activated ERS as evidenced upregulation p-PERK, p-eIF2α, CHOP caspase 3. Consistently, postsynaptic density 95 (PSD95) synaptophysin (SYN) expressions indicated modifications function. Notably, impacts on neurons found mitigated CDN1163 treatment both vitro. Additionally, SERCA-mediated apoptosis attenuated GSK2606414 via inhibiting PERK-eIF2α-CHOP axis not only curtailed level 3, but elevated levels PSD95 SYN. Conclusions: These findings highlight significant impact impairment, further elucidate underlying mechanism involving SERCA/PERK/eIF2α pathway.

Language: Английский

The firestorm within: A narrative review of extreme heat and wildfire smoke effects on brain health DOI
Anthony R. White

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171239 - 171239

Published: Feb. 27, 2024

Language: Английский

Citations

7
Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway DOI Creative Commons
Hongxia Li,

Wenlan Pan,

Chenqi Li

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 11, 2024

Abstract Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms underlie this phenomenon have yet to be extensively investigated. The Morris water maze test was utilized assess performance. RNA sequencing employed discover primary regulators and pathological pathways involved in impairment caused by heat. Before heat vivo vitro, activation of sarco/endoplasmic reticulum (SR/ER) calcium (Ca 2+ )-ATPase (SERCA) achieved CDN1163. Hematoxylin-Eosin, Nissl staining, imaging, transmission electron microscopy, western blot, immunofluorescence were visualize histological changes, intracellular levels, endoplasmic stress (ERS) markers, apoptosis, synaptic proteins alterations. (HS) significantly induced decline neuronal damage mice. By transcriptome between control ( n = 5) mice hippocampal tissues, we identified a reduction expression atp2a gene encoding SERCA, accompanied corresponding decrease its protein level. Consequently, dysregulation resulted excessive accumulation ions. Furthermore, HS also activated ERS as evidenced upregulation p-PERK, p-eIF2α, CHOP, caspase-3. Consistently, postsynaptic density 95 (PSD95) synaptophysin (SYN) expressions indicated modifications function. Notably, impacts on neurons found mitigated CDN1163 treatment both vitro. Additionally, SERCA-mediated ERS-induced apoptosis attenuated GSK2606414 via inhibiting PERK-eIF2α-CHOP axis not only curtailed level caspase-3 but elevated levels PSD95 SYN. These findings highlight significant impact impairment, further elucidate underlying mechanism involving SERCA/PERK/eIF2α pathway.

Language: Английский

Citations

5
Two-decade surface ozone (O3) pollution in China: Enhanced fine-scale estimations and environmental health implications DOI
Zeyu Yang, Zhanqing Li,

Fan Cheng

et al.

Remote Sensing of Environment, Journal Year: 2024, Volume and Issue: 317, P. 114459 - 114459

Published: Nov. 21, 2024

Language: Английский

Citations

5
Effect Modification of Heatwaves on the Association of Long-Term Ozone Exposure and Cardiovascular Disease among older adults in China: a National Representative Cross-sectional Study DOI Creative Commons
Y Li,

Xinran Shen,

Chen Chen

et al.

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Jan. 1, 2025

Language: Английский

Citations

0
The combined effects of sleep and extreme heat exposure on cognitive function among older adults DOI Creative Commons
Wensu Zhou, Xuezhu Li, Qiong Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117683 - 117683

Published: Jan. 1, 2025

Extreme heat is linked to cognitive impairment. Normal sleep duration and good quality can reduce impairment risks. However, the combined impact of (duration quality) extreme on unclear. This study tests whether normal during a heatwave compared poor long in older adults. used cohort data from 9153 was defined as periods ≥ 3 days with daily minimum temperatures above 92.5th percentile warm season. Cognitive function assessed Mini-Mental State Examination (MMSE). Sleep categorized long, normal, or short, poor. Six four categories were for combinations exposure quality, respectively. Cox regression models applied analysis. Compared those heatwaves, participants exposed heatwaves had lower risk (HR: 0.86, 95 %CI: 0.76-0.97). Those short also showed risks 0.74, 0.62-0.88). heatwave, did not show significantly 1.10, 0.98-1.23). Older adults may face risks, highlighting importance guidance protect health heat.

Language: Английский

Citations

0
Closing the gap in dementia research by community-based cohort studies in the Chinese population DOI Creative Commons

Xiaowen Zhou,

Zhenxu Xiao, Wanqing Wu

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: 55, P. 101465 - 101465

Published: Jan. 21, 2025

Language: Английский

Citations

0
Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment DOI Creative Commons
Keisuke Kokubun, Kiyotaka Nemoto, Toshiharu Ikaga

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121033 - 121033

Published: Jan. 1, 2025

Language: Английский

Citations

0
Associations between neutrophil–lymphocyte ratio and risk of cognitive impairment among Chinese older adults DOI Creative Commons
Xin Wang, Binbin Wang,

Xueqing Du

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 19, 2025

Associations between the neutrophil–lymphocyte ratio (NLR) and cognitive performance in older population are rarely reported. We investigated associations NLR risk of impairment Chinese community-dwelling adults. Individuals aged ≥ 65 years from 2011 2014 waves Longitudinal Healthy Longevity Survey were enrolled. used version Mini-Mental State Examination to evaluate function, with a score <18 indicating impairment. was expressed as derived (white blood cell count − lymphocyte count]/lymphocyte count). Logistic regression association levels The study enrolled 2375 cognitively healthy participants 838 Significantly higher values noted latter than former group. In cross-sectional analysis, highest lowest quartile indicated significantly increased impairment, after controlling for all confounding factors. During follow-up, 134 1173 at baseline developed two quartiles those quartile. When classified into dichotomous groups, high-inflammation noninflammatory status group, regardless analysis (cross-sectional or prospective). Elevated is associated

Language: Английский

Citations

0
Associations of green and blue spaces with visual acuity in youths from Shandong Province, China: A large population-based study DOI Creative Commons

Xiaoyun Ma,

Gaohui Zhang,

Xue Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117947 - 117947

Published: Feb. 26, 2025

Language: Английский

Citations

0
Associations between heat waves and chronic kidney disease in China: The modifying role of land cover DOI Creative Commons
Wanzhou Wang, Fulin Wang, Chao Yang

et al.

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108657 - 108657

Published: April 1, 2024

The increasing frequency of heat waves under the global urbanization and climate change background poses elevating risks chronic kidney disease (CKD). Nevertheless, there has been no evidence on associations between long-term exposures to CKD as well modifying effects land cover patterns. Based a national representative population-based survey covering 47,086 adults high spatial resolution datasets temperature data, we found that annual days exposure were associated with increased odds prevalence. For one day/year increases in HW_975_4d (above 97.5 % maximum lasting for at least 4 consecutive days), ratio (OR) was 1.14 (95 %CI: 1.12, 1.15). Meanwhile, stronger observed regions lower urbanicity [rural: 1.16) vs urban: 1.07 1.03, 1.11), Pinteraction < 0.001], water body coverage [lower: higher: 1.02 0.98, 1.05), impervious area 1.16 1.14, 1.18) 1.06 1.10), = 0.008]. In addition, this study disparities bodies areas rural urban settings. regions, prevalence showed consistent decreasing trend both proportions (Pinteraction 0.05). significant effect modification by bodies, but not areas. Our indicates need targeted planning part adapting impacts waves, focus construction utilization regions.

Language: Английский

Citations

2