Examining the effect of iron (ferric) on physiological processes: Invertebrate models DOI

Mikaela L. Wagers,

Ashley Starks,

Jeremy Nadolski

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 278, P. 109856 - 109856

Published: Feb. 13, 2024

Language: Английский

Ramulus Mori (Sangzhi) Alkaloids Alleviate Diabetic Nephropathy through Improving Gut Microbiota Disorder DOI Open Access

Wenxiu Liu,

Saijun Xu, Bin Zhang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2346 - 2346

Published: July 20, 2024

Diabetic nephropathy (DN), one of the leading causes end-stage kidney failure worldwide, is closely associated with high mortality in diabetic patients. However, therapeutic drugs for DN are still lacking.

Language: Английский

Citations

5
Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer DOI
Yuan Zhang,

Jinheng Qian,

Yanneng Fu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167447 - 167447

Published: July 30, 2024

Language: Английский

Citations

5
Ferroptosis-Related Oxaliplatin Resistance in Multiple Cancers: Potential Roles and Therapeutic Implications DOI Creative Commons

Si-Jia Zhong,

Zihan Wang,

Jiaxi Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37613 - e37613

Published: Sept. 1, 2024

Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing

Language: Английский

Citations

5
Spotlight on iron overload and ferroptosis: Research progress in female infertility DOI
Jinghua Zhang, Tiantian Su, Yuan Fan

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 340, P. 122370 - 122370

Published: Dec. 22, 2023

Language: Английский

Citations

11
In situ profiling reveals spatially metabolic injury in the initiation of polystyrene nanoplastic-derived intestinal epithelial injury in mice DOI

Xianan Zhang,

Jing Wang, Yuansheng Liu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172037 - 172037

Published: April 2, 2024

Language: Английский

Citations

4
Relationship between iron and lipid peroxidation in ferroptosis and effect of ferroptosis in metabolic dysfunction-associated steatotic liver disease DOI

Meng-Juan Ma,

Jie Lin, Hongju Yang

et al.

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(1), P. 34 - 42

Published: Jan. 22, 2025

Language: Английский

Citations

0
Relationship between iron and lipid peroxidation in ferroptosis and effect of ferroptosis in metabolic dysfunction-associated steatotic liver disease DOI

Meng-Juan Ma,

Jie Lin, Hongju Yang

et al.

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(1), P. 28 - 36

Published: Jan. 25, 2025

Language: Английский

Citations

0
Retinoic Acid Mitigates Iron Overload-Exacerbated Intestinal Ferroptosis in Escherichia Coli-Infected Weaned Piglets DOI
Xin Lai, Junzhou Chen, Chen Liu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs DOI Creative Commons
Bei Zhou, Junjie Guo, Kan Xiao

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 25, 2025

Abstract Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human mouse models have shown that ferroptosis closely related to tissue damage various diseases. In recent years, has also been found play an indispensable multifaceted role infection injury pigs, nutritional regulation strategies targeting show great potential. this review, we summarize the research progress its pigs. Furthermore, discuss existing evidence on nutrients, aiming provide valuable insights for future investigation into pigs offer novel perspective treatment

Language: Английский

Citations

0
Gut microbiota participates in polystyrene microplastics-induced defective implantation through impairing uterine receptivity DOI
Jiani Sun, Lulu Geng, Dan Zhou

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 380, P. 124997 - 124997

Published: March 17, 2025

Language: Английский

Citations

0