Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
287, P. 117268 - 117268
Published: Nov. 1, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
have
attracted
significant
attention
due
to
their
environmental
toxicity.
However,
the
detrimental
impact
of
PFAS
on
development
female
reproductive
system
remains
controversial.
In
this
study,
we
investigated
effects
three
specific
compounds
perfluorooctanoic
acid
(PFOA),
perfluorononanoic
(PFNA),
perfluorodecanoic
(PFDA)
ovarian
development.
Among
these
compounds,
PFDA
demonstrated
most
pronounced
cytotoxic
effect
granulosa
cells.
The
results
showed
that
a
200
μM
concentration
induced
cell
apoptosis
via
intrinsic
pathway
by
elevating
reactive
oxygen
species
(ROS)
levels
activating
Caspase-9
Caspase-3.
Furthermore,
triggered
necroptosis,
form
regulated
death
(RCD),
through
receptor-interacting
serine/threonine
kinase
1
(RIPK1),
receptor
interacting
protein
3
(RIPK3),
mixed-lineage
domain-like
(MLKL)
axis,
mediated
inhibition
canonical
proteolytic
enzyme
Caspase-8.
vivo
experiments
confirmed
mice
exposed
displayed
significantly
reduced
index
compared
control
group,
accompanied
evident
follicular
atresia.
Ovarian
tissues
from
PFDA-exposed
group
upregulated
necroptosis
markers,
which
were
effectively
mitigated
inhibiting
phosphorylation
RIPK1
at
Ser166.
Importantly,
study
provides
first
evidence
disrupts
novel
mechanism
involving
RIPK1-mediated
pathway,
alongside
detection
pathway.
This
greatly
expands
our
insight
into
death.
finding
highlights
potential
public
health
hazards
associated
with
exposure
emphasizes
need
for
further
research
fully
understand
its
broader
implications.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 111 - 111
Published: Jan. 28, 2024
This
study
delves
into
the
critical
issue
of
water
pollution
caused
by
presence
metal
oxides,
synthetic
dyes,
and
dissolved
organic
matter,
shedding
light
on
their
potential
ramifications
for
both
environment
human
health.
Metal
ubiquitous
in
industrial
processes
consumer
products,
are
known
to
leach
bodies,
posing
a
significant
threat
aquatic
ecosystems.
Additionally,
extensively
used
various
industries,
can
persist
systems
exhibit
complex
chemical
behavior.
review
provides
comprehensive
examination
toxicity
associated
with
matter
systems.
We
delve
sources
environmental
fate
these
contaminants,
highlighting
prevalence
natural
bodies
wastewater
effluents.
The
highlights
multifaceted
impacts
them
health
ecosystems,
encompassing
effects
microbial
communities,
flora
fauna,
overall
ecological
balance.
novelty
this
lies
its
unique
presentation,
focusing
matter.
approach
aims
facilitate
accessibility
results
readers,
providing
streamlined
clear
understanding
reported
findings.
Toxicological Sciences,
Journal Year:
2024,
Volume and Issue:
200(2), P. 312 - 323
Published: May 17, 2024
Abstract
Cardiovascular
diseases
(CVDs)
are
one
of
the
major
causes
death
globally.
In
addition
to
traditional
risk
factors
such
as
unhealthy
lifestyles
(smoking,
obesity,
sedentary)
and
genetics,
common
environmental
exposures,
including
persistent
contaminants,
may
also
influence
CVD
risk.
Per-
polyfluoroalkyl
substances
(PFASs)
a
class
highly
fluorinated
chemicals
used
in
household
consumer
industrial
products
known
persist
our
environment
for
years,
causing
health
concerns
that
now
linked
endocrine
disruptions
related
outcomes
women,
interference
cardiovascular
reproductive
systems.
postmenopausal
higher
levels
PFAS
observed
than
premenopausal
women
due
cessation
menstruation,
which
is
crucial
excretion.
Because
these
findings,
we
explored
association
between
perfluorooctanoic
acid
(PFOA),
perfluorooctane
sulfonate
(PFOS),
perfluorobutanesulfonic
from
previously
established
study.
We
liquid
chromatography
with
tandem
mass
spectrometry,
supported
by
machine
learning
approaches,
detection
quantification
serum
metabolites
proteins.
Here,
show
PFOS
can
be
good
predictor
coronary
artery
disease,
whereas
PFOA
an
intermediate
microvascular
disease.
found
study
significantly
associated
inflammation-related
Our
findings
provide
new
insight
into
potential
mechanisms
underlying
PFAS-induced
CVDs
this
population.
This
shows
exposure
increased
disease
women.
correlate
amino
acids
proteins
inflammation.
These
circulating
biomarkers
contribute
etiology
potentially
implicate
mechanistic
relationship
events
Integrated Environmental Assessment and Management,
Journal Year:
2025,
Volume and Issue:
21(1), P. 208 - 219
Published: Jan. 1, 2025
This
research
aims
to
address
the
data
gaps
in
freshwater
ecotoxicological
characterization
factors
(CFs)
for
per-
and
polyfluoroalkyl
substances
(PFASs).
These
CFs
are
essential
incorporating
ecotoxicity
impacts
of
PFAS
emissions
into
life
cycle
assessments
(LCAs).
study
has
three
primary
objectives:
first,
calculate
a
comprehensive
set
experimental
aquatic
PFASs
utilizing
USEtox
model
(version
2.13);
second,
compare
these
newly
derived
with
those
generated
using
PFAS-adapted
model;
finally,
test
hypothesis
concerning
potential
correlation
between
effect
(EFs)
number
perfluorinated
carbons
PFASs.
In
this
study,
367
were
selected
from
CompTox
Chemicals
Dashboard
suspect
lists
REACH
(Registration,
Evaluation,
Authorisation
Restriction
Chemicals)
registration
dossiers.
Experimental
extracted
Version
2.1.1
REACH.
Using
both
2.13)
model,
calculated
Of
these,
237
HC20EC10eq-based
methodology,
enriching
representation
LCA
studies.
The
analysis
revealed
no
EFs
models.
covers
only
small
portion
extensive
list
millions
PubChem,
primarily
due
constraints
scarcity.
Discrepancies
by
attributed
variations
foundational
fate
exposure
factor
calculation
methodologies,
whereas
remained
consistent.
Consequently,
it
is
suggested
that
dependent
on
modeling
approach
require
regular
updates
latest
ensure
accuracy
relevance.
