Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism DOI
Zhipeng Qi,

Yue Zhai,

Yi Han

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Estrogens play a crucial role in regulating various biological responses during the early stages of neurodevelopment. Benzophenone-2 (BP2), widely used organic ultraviolet (UV) filter, has been proven as an estrogenic compound, whereas effects BP2 on neurodevelopment remain largely unknown. Here, we investigated neurodevelopmental toxicity by exposing zebrafish embryos from 2 to 120 h postfertilization (hpf) at environmentally relevant concentrations. We demonstrated that life exposure induced multiple concentration-dependent impairments nervous system, including hypoactivity, abnormal brain morphology, impaired neurocyte proliferation, shortened axon, and increased apoptosis. Moreover, metabolomic profiling revealed decrease dopamine (DA) its metabolites BP2-treated larvae. Using E2 treatment morpholino knockdown assays, provided strong genetic evidence BP2-induced behavioral disorders were associated with estrogen-dependent signaling, especially estrogen receptors 2a 2b (esr2). Subsequently, transcriptomic indicated activation esr2 further inhibited expression LIM homeobox transcription factor 1 β (lmx1ba), which is vital for normal Consistently, overexpression lmx1ba inhibition obviously alleviated BP2-caused neurotoxicity, uncovering seminal toxicity. Our findings provide first fish can induce deficits dysfunction offer novel insights into mechanisms well other emerging benzophenones.

Language: Английский

Iron-loaded Chinese herbal medicine residue biochar for heterogeneous catalytic ozonation of malathion wastewater DOI
Yihan Chen, Di Chai, Xiangyu Zhang

et al.

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 131880 - 131880

Published: Feb. 1, 2025

Language: Английский

Citations

1
Expression of glucocorticoid-receptor covaries with individual differences in visual lateralisation in zebrafish DOI Creative Commons
Eleonora Rovegno, Elena Frigato, Luisa Dalla Valle

et al.

Animal Cognition, Journal Year: 2025, Volume and Issue: 28(1)

Published: March 13, 2025

Abstract Cerebral lateralisation, the differential cognitive processing in two brain hemispheres, is variable among individuals most vertebrates. Part of this variance has been attributed to plasticity response environmental stressors experienced by and might be therefore mediated action glucocorticoids (GCs). Accordingly, we tested hypothesis that GC pathway related stress, which involved its cognate receptor GR, affects individuals’ lateralisation. First, characterised behavioural lateralisation phenotype outbred wild-type zebrafish using three different tests: a motor test, test involving visual social stimulus (subject’s mirror image), with negative valence (predator). Subsequently, quantified expression gr gene subjects, specifically telencephalon mesencephalon each hemisphere. Our population exhibited individual variation but no population-level bias across hemispheres. When correlated patterns tests expression, observed higher mesencephalic right hemisphere were more inclined process their image Additionally, telencephalon, showed reduced predator stimulus. This study supports GCs affect some aspects particular those stimuli, thought GC-Gr suggests intraspecific could result from differences expression.

Language: Английский

Citations

1
Advances in plant essential oils and drug delivery systems for skincare DOI Creative Commons
Yihan Wang,

Dou Jin-jin,

Wang Yingqi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Using keywords such "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects anti-inflammatory," "anti-anxiety," "drug carrier systems," a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Language: Английский

Citations

0
Exposure assessment of dairy cows to parabens using hair samples analysis DOI Creative Commons
Sławomir Gonkowski, Manolis Tzatzarakis,

Nariste Kadyralieva

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 21, 2024

Parabens (PBs) are used as preservatives in various products. They pollute the environment and penetrate living organisms, showing endocrine disrupting activity. Till now studies on long-term exposure of farm animals to PBs have not been performed. Among matrices using biomonitoring hair samples becoming more important. During this study concentration levels methyl paraben (MeP), ethyl (EtP), propyl (PrP) butyl (BuP) benzyl (BeP) were evaluated liquid chromatography-mass spectrometry (LC-MS) collected from dairy cows bred Kyrgyz Republic. MeP was noted 93.8% (with mean 62.2 ± 61.8 pg/mg), PrP 16.7% (12.4 6.5 pg/mg) EtP 8.3% (21.4 11.9 pg/mg). BuP found only one sample (2.1%) BeP detected any included study. Some differences depending district, where noted. This has shown that among PBs, exposed mainly MeP, may be a suitable matrix for research animals.

Language: Английский

Citations

3
A systematic review of the toxic potential of parabens in fish DOI Creative Commons
Asok K. Dasmahapatra,

Joydeep Chatterjee,

Paul B. Tchounwou

et al.

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 7, 2024

Parabens are the most prevalent ingredients in cosmetics and personal care products (PCPs). They colorless tasteless exhibit good stability when combined with other components. Because of these unique physicochemical properties, they extensively used as antimicrobial antifungal agents. Their release into aquatic ecosystem poses potential threats to organisms, including fish. We conducted an electronic search PubMed ( http://www.ncbi.nlm.nih.gov/pubmed ) using term parabens fish sorted 93 articles consisting methyl paraben (MTP), ethyl (ETP), propyl (PPP), butyl (BTP), benzyl (BNP) several species. Furthermore, we confined our six species (common carp, Cyprinus carpio ; fathead minnows, Pimephales promelas Japanese medaka, Oryzias latipes rainbow trout, Oncorhynchus mykiss Nile tilapia, Oreochromis niloticus zebrafish, Danio rerio) four common (MTP, ETP, PPP, BTP) 48 for review. Our indicates that among all fish, zebrafish was studied MTP tested Moreover, depending on alkyl chain length linearity, long-chained were more toxic than short chains. can be considered endocrine disruptors (EDs), targeting estrogen-androgen-thyroid-steroidogenesis (EATS) pathways, blocking development growth gametes, causing intergenerational toxicity impact viability offspring/larvae. Paraben exposure also induce behavioral changes nervous system disorders Although USEPA EU limit use pharmaceuticals, their prolonged persistence environment may pose additional health risk humans.

Language: Английский

Citations

3
Problems of using phenol (hydroxybenzene) and parabens as pharmaceutical stabilizers: analysis using machine learning methods DOI Creative Commons
I. Yu. Torshin, О. А. Громова

FARMAKOEKONOMIKA Modern Pharmacoeconomics and Pharmacoepidemiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Background. Phenol and parabens exert bactericidal properties, are relatively low-toxic (in acute toxicity tests) used in pharmaceutical, cosmetic food industries as stabilizers/preservatives for the final product. Despite their widespread use, long-term toxicological effects of phenol remain largely unexplored. Objective: to conduct an analysis results basic clinical studies on chronic parabens. Material methods. The study included 544 articles found using query “Preservatives, Pharmaceutical [MeSH Terms] AND Terms]” PubMed/MEDLINE biomedical publications database. Methods topological metric big data were applied, developed scientific school Academician Russian Academy Sciences Yu.I. Zhuravlev. Keywords sorted by empirical Rudakov–Torshin informativeness functionals context combinatorial theory solvability, followed testing solvability find terms with greatest informativeness. Results. existence individual its derivatives (including parabens), remains poorly understood. This fact is indicated not only a lack carefully performed research, but also information safety sheets supplied manufacturers relevant substances. associations paraben blood levels certain pathologies humans have been insufficiently studied. At same time, authors fundamental if “sound alarm,” then strongly underline need large-scale trials toxic Firstly, this due complex estrogen-like effect parabens, including (1) estrogen sulfotransferases, (2) direct interactions receptors, (3) influence expression steroid receptor genes. Secondly, available from research indicate that phenol/parabens obviously stimulate molecular mechanisms oncogenesis pathophysiology (systematic disturbances gene corresponding changes structure organ tissues). Thirdly, teratogenic other embryo pregnancy demonstrated experimental (neurotoxicity teratogenesis animal models), observations (metabolic disorders pregnant woman, metabolism purines fatty acids beta-oxidation, hyperactivity and/or excess body weight children, asthma, thyroid dysfunction, etc.). Conclusion. Findings selected dictate urgent examine association phenol/paraben cross-sectional longitudinal design. indication phenols may just be artifact incorrect analysis.

Language: Английский

Citations

1
Life-Time Exposure to Decabromodiphenyl Ethane (Dbdpe) Caused Transgenerational Epigenetic Alterations of Thyroid Endocrine System in Zebrafish DOI

Yumiao Sun,

Xiaochen Wang, Wei Guo

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Paraben Preservatives Exhibit Inhibition on Human and Rat Steroid 5α-Reductase 1: A Comprehensive 3D-QSAR and Computational Analysis DOI
He Zhu,

Chentao Ding,

Yunbing Tang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135841 - 135841

Published: Sept. 20, 2024

Language: Английский

Citations

0
Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism DOI
Zhipeng Qi,

Yue Zhai,

Yi Han

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Estrogens play a crucial role in regulating various biological responses during the early stages of neurodevelopment. Benzophenone-2 (BP2), widely used organic ultraviolet (UV) filter, has been proven as an estrogenic compound, whereas effects BP2 on neurodevelopment remain largely unknown. Here, we investigated neurodevelopmental toxicity by exposing zebrafish embryos from 2 to 120 h postfertilization (hpf) at environmentally relevant concentrations. We demonstrated that life exposure induced multiple concentration-dependent impairments nervous system, including hypoactivity, abnormal brain morphology, impaired neurocyte proliferation, shortened axon, and increased apoptosis. Moreover, metabolomic profiling revealed decrease dopamine (DA) its metabolites BP2-treated larvae. Using E2 treatment morpholino knockdown assays, provided strong genetic evidence BP2-induced behavioral disorders were associated with estrogen-dependent signaling, especially estrogen receptors 2a 2b (esr2). Subsequently, transcriptomic indicated activation esr2 further inhibited expression LIM homeobox transcription factor 1 β (lmx1ba), which is vital for normal Consistently, overexpression lmx1ba inhibition obviously alleviated BP2-caused neurotoxicity, uncovering seminal toxicity. Our findings provide first fish can induce deficits dysfunction offer novel insights into mechanisms well other emerging benzophenones.

Language: Английский

Citations

0