Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 768 - 768

Published: April 30, 2024

We have described the influence of selected factors that increase toxicity nanoplastics (NPs) and microplastics (MPs) with regard to cell viability, various types death, reactive oxygen species (ROS) induction, genotoxicity. These include plastic particle size (NPs/MPs), zeta potential, exposure time, concentration, functionalization, environmental type. Studies unequivocally shown smaller particles are more cytotoxic, penetrate cells easily, ROS formation, induce oxidative damage proteins, lipids, DNA. The toxic effects also concentration incubation time. NPs positive potential than those a negative because negatively charged, inducing stronger interactions. deleterious MPs increased by functionalization anionic or carboxyl groups, due greater interaction membrane components. Cationic NPs/MPs particularly their cellular uptake and/or on lysosomal membranes. polystyrene (PS) vary from one type another, normal sensitive cancerous ones. can be enhanced factors, including UV radiation, as they cause shrink change shape, which is important consideration when working environmentally-changed NPs/MPs. In summary, cytotoxicity, properties, genotoxicity depends duration action, Also, diameter exposed functionalized amino demonstrate higher larger, non-functionalized environmentally-unchanged potential.

Language: Английский

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Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137274 - 137274

Published: Jan. 17, 2025

Language: Английский

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Microplastics in human skeletal tissues: Presence, distribution and health implications

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109316 - 109316

Published: Feb. 1, 2025

Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs (159.5 103.8 μm) (138.86 105.67 larger that (87.5 30.7 μm). most frequently identified polymers polypropylene (35 %), ethylene vinyl acetate copolymer (30 polystyrene (20 %). vivo experiment suggested invaded through blood circulation after 4 weeks exposure. Serum levels tumor necrosis factor-α (TNF-α), Type Ⅰ procollagen amino-terminal peptide (PINP), tartrate-resistant acid phosphatase-5b (TRACP-5b) elevated compared with control group (p < 0.05). Our study suggests invade supply, causing distinct accumulation these regions. Microplastic invasion can affect health by influencing expression inflammatory morphogenetic cytokines. These findings provide insights into investigating impact on health.

Language: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

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Membrane-based technologies for removing emerging contaminants in urban water systems: Limitations, successes, and future improvements

Desalination, Journal Year: 2024, Volume and Issue: 590, P. 117974 - 117974

Published: Aug. 4, 2024

Language: Английский

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Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 933, P. 173012 - 173012

Published: May 6, 2024

Language: Английский

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The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

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Using Insect Larvae and Their Microbiota for Plastic Degradation

Insects, Journal Year: 2025, Volume and Issue: 16(2), P. 165 - 165

Published: Feb. 5, 2025

Plastic pollution is one of the biggest current global threats to environment given that petroleum-based plastic recalcitrant and can stay in for decades, even centuries, depending on specific type. Since less than 10% all made recycled, other solutions (such as incineration or landfill storage) are pollutant methods, new, environmentally friendly needed. In this regard, latest biotechnological discovery topic capability insect larvae use polymers carbon feedstock. This present review describes most relevant information capable degrading plastic, mainly Galleria mellonella (Fabricius, 1798), Tenebrio molitor (Linnaeus, 1758), Zophobas atratus 1776), also adds new about commonly studied “plastivore” insects such termites. covers literature from very first work describing degradation by published 2014 way research available (till June 2024), focusing identification a wide variety plastic-degrading microorganisms isolated guts understanding potential molecular mechanisms take place. It discoveries, which include novel enzymes waxworm saliva.

Language: Английский

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Ecological and Health Risk Mediated by Micro(nano)plastics Aging Process: Perspectives and Challenges

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Aged micro(nano)plastics (MNPs) are normally the ultimate state of plastics in environment after aging. The changes physical and chemical characteristics aged MNPs significantly influence their environmental behavior by releasing additives, forming byproducts, adsorbing contaminants. However, a systematic review is lacking on effects ecological human health regarding increasing but scattered studies results. This Review first summarizes unique methods for quantifying aging degree. Then we focused potential impacts organisms, ecosystems, health, including "Trojan horse" under real conditions. Through combining meta-analysis analytic hierarchy process (AHP) model, demonstrated that, compared to virgin MNPs, would result biomass decrease oxidative stress increase organisms lead total N/P greenhouse gas emissions ecosystems while causing cell apoptosis, antioxidant system reaction, inflammation health. Within framework risk assessment, used quotient (RQ) physiologically based pharmacokinetic (PBK) models as examples illustrate importance considering degree data acquisition, model building, formula evaluation. Given risks our urgent call more understand hazards real-world environments.

Language: Английский

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Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(21), P. 9071 - 9081

Published: May 15, 2024

Little research exists on the magnitude, variability, and uncertainty of human exposure to airborne micro- nanoplastics (AMNPs), despite their critical role in MNPs. We probabilistically estimate global intake AMNPs through three main pathways: indoor inhalation, outdoor ingestion during meals, for both children adults. The median inhalation AMPs is 1,207.7 (90% CI, 42.5–8.48 × 104) 1,354.7 47.4–9.55 N/capita/day adults, respectively. annual 13.18 mg/capita/a 19.10 which approximately one-fifth one-third mass a standard stamp, assuming consistent daily medians. majority AMP number occurs while deposited meals contributes most terms mass. Furthermore, ANP 9,638.1 N/day (8.23 10–6 μg/d) 5,410.6 (4.62 respectively, compared 5.30 105 (5.79 10–4 6.00 (6.55 via inhalation. Considering increased toxicity smaller MNPs, significant ANPs inhaled warrants great attention. Collaborative efforts are imperative further elucidate combat current MPN risks.

Language: Английский

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