Airborne micro- and nanoplastics: emerging causes of respiratory diseases DOI Creative Commons
Zixuan Gou, Haonan Wu, Shanyu Li

et al.

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 4, 2024

Airborne micro- and nanoplastics (AMNPs) are ubiquitously present in human living environments pose significant threats to respiratory health. Currently, much research has been conducted on the relationship between (MNPs) cardiovascular gastrointestinal diseases, yet there is a clear lack of understanding regarding link AMNPs diseases. Therefore, it imperative explore two. Recent extensive studies by numerous scholars characteristics their with diseases have robustly demonstrated that from various sources significantly influence onset progression conditions. Thus, investigating intrinsic mechanisms involved finding necessary preventive therapeutic measures crucial. In this review, we primarily describe fundamental AMNPs, impact system, toxic facilitate disease development. It hoped article will provide new insights for further contribute advancement

Language: Английский

Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade DOI
Jing Liu, Fang Xu,

Mingzhu Guo

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174674 - 174674

Published: July 11, 2024

Language: Английский

Citations

5
Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review DOI Creative Commons
Nicholas Chartres, Courtney Cooper, Garret D. Bland

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Microplastics are ubiquitous environmental contaminants for which there documented human exposures, but is a paucity of research evaluating their impacts on health. We conducted rapid systematic review using the "Navigation Guide" method. searched four databases in July 2022 and April 2024 with no restriction date. included studies predefined eligibility criteria that quantitatively examined association microplastic exposure any health outcomes. amended after screening prioritized digestive, reproductive, respiratory outcomes further evaluation. three observational examining reproductive (

Language: Английский

Citations

5
Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells DOI
Nara Kim, Jae Hoon Lee, Inha Lee

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108848 - 108848

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study DOI

Ying Liang,

Zi Wang,

Deyang Huo

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(29), P. 16250 - 16262

Published: June 25, 2024

In recent years, there has been a growing concern regarding health issues arising from exposure to nanoplastics (Nps) in the natural environment. The Nps bioaccumulate within body

Language: Английский

Citations

4
Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes DOI Creative Commons
Shirley Pei Shan Chia, Jeremy Kah Sheng Pang,

Winanto Winanto

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117657 - 117657

Published: Jan. 1, 2025

Nanoplastics (NPs), plastic particles ranging from 1-1000 nm, form through weathering and are considered more hazardous than larger plastics due to their ability penetrate cell barriers be internalised by biological systems. Most research on NPs has focused animal models, examining effects the brain, lungs, gastrointestinal tract. To enhance physiological relevance, this study investigated impact of human cardiomyocytes (CMs) derived embryonic stem cells (hESCs). We observed significantly higher cellular uptake 50 nm compared 500 particles, with dose-dependent accumulation over 3, 5, 7 days treatment. This induced oxidative endoplasmic reticulum (ER) stress, culminating in arrhythmias day 7. Complementing these vitro findings, transcriptome profiling mice exposed for 8 weeks revealed disrupted RNA splicing, dysregulated protein translation, defective folding. These molecular changes led ER apoptosis, impaired transmembrane ion conductance, contributing arrhythmic phenotype. Our findings highlight detrimental heart. Further is needed fully elucidate mechanisms underlying NP-induced toxicity develop strategies mitigating adverse effects. underscores urgency addressing NP pollution protect health.

Language: Английский

Citations

0
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma DOI Creative Commons
Haihua Wang, Songqing Fan, Yuting Zhan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 16, 2025

Approximately 80% of nasopharyngeal carcinoma (NPC) patients exhibit EGFR overexpression. The overexpression has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. We discovered that EGFR, operating a kinase-independent manner, played stabilizing the expression SLC7A11, which subsequently inhibited MHC-I antigen presentation. This mechanism, turn, provided protection NPC cells against T cell-mediated cytotoxicity. underlying molecular processes revealed high and stable SLC7A11 hindered nuclear entry GR, thereby suppressing TAP1 transcription presentation Additionally, elevated led an increase FAF2 triggered ERAD-dependent degradation MHC-I, resulting reduction molecules on cell membrane. exhibiting low expression, combined with scarcity CD8+ (EGFRhighMHC-IlowCD8few phenotype), experienced considerably shorter overall survival times compared other situations. What is more, our study demonstrated sorafenib had capability enhance process, facilitating killing via targeting SLC7A11. Consequently, emerges as promising therapeutic strategy for treatment NPC.

Language: Английский

Citations

0
Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways DOI

Khadija Boukholda,

Awatef Elwej,

Sabrine Ben Slimen

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
SIRT1 Alleviates Oxidative Stress‐Induced Mitochondrial Dysfunction and Mitochondria‐Associated Membrane Dysregulation in Stress Urinary Incontinence DOI Creative Commons
Liying Chen, Jianming Tang, Xiaohu Zuo

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

The pathogenesis of stress urinary incontinence (SUI), a condition common in women, remains to be fully elucidated. This study revealed that the incidence SUI is associated with mitochondrial homeostasis dysregulation following oxidative fibrous connective tissue pelvic floor. SIRT1 an essential factor for maintaining homeostasis; however, its potential role and mechanism action remain unclear. Both vitro vivo, we observed reduced expression inhibit PGC-1α/NRF1/TFAM PINK1/Parkin signalling pathways, eliciting impairment biogenesis mitophagy L929 cells mice. Decreased levels induced endoplasmic reticulum (ER) altered structure mitochondria-associated membranes (MAMs), disrupting ER-mitochondrial calcium exacerbting ROS accumulation. activation can restore function MAMs alleviate ER fibroblasts, promoting anterior vaginal wall repair improving urodynamic parameters model. Our findings provide novel insights into ameliorating stress-induced dysfunction fibroblasts propose as therapeutic target SUI.

Language: Английский

Citations

0
Exposure of the human placental primary cells to nanoplastics induces cytotoxic effects, an inflammatory response and endocrine disruption DOI Creative Commons
Léa Poinsignon, Bertrand Lefrère, Abdelhamid Benazzouz

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137713 - 137713

Published: Feb. 26, 2025

Humans are inevitably exposed to micro- and nanoplastics (MP/NP). These particles able cross the biological barriers enter bloodstream with levels close 1.6 µg mL-1; MP/NP have been detected in placentas meconium of newborns. However, consequences this exposure on integrity, development functions human placenta not documented. In study, trophoblasts purified from at term were for 48 h, two different sizes polystyrene nanoparticles (PS-NP) 20 nm (PS-NP20) 100 (PS-NP100), environmental supra-environmental concentrations (0.01-100 mL-1). Cell viability, oxidative stress, mitochondrial dynamics, lysosomal degradation processes, autophagy, inflammation/oxidative responses placental endocrine angiogenic assessed. PS-NP size determines their internalization rate behavior trophoblasts. Indeed, PS-NP20 more rapidly translocated, accumulated lysosomes as shown by confocal TEM imaging. They induce higher cytotoxicity than PS-NP100, early 1 mL-1 (p < 0.05). addition, they a pro-inflammatory cytokines response: IL-1ß is induced 0.01 both nanoparticle sizes; IL-6, TNF-α overexpressed only For first time, we report that disrupt function, observed decreased hCG release found blood. This work, provides an in-depth vitro assessment effects placenta.

Language: Английский

Citations

0
Gender-specific effects of prenatal polystyrene nanoparticle exposure on offspring lung development DOI

Wenxia Bu,

Mengjiao Yu,

Xinyi Ma

et al.

Toxicology Letters, Journal Year: 2025, Volume and Issue: 407, P. 1 - 16

Published: March 13, 2025

Language: Английский

Citations

0