1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity DOI Creative Commons
Anna Merwid‐Ląd, Piotr Ziółkowski, Beata Nowak

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 546 - 546

Published: April 8, 2025

Background/Objectives: Inflammatory bowel disease significantly impairs the patient’s quality of life. In young individuals, both and drugs used for treatment may impact fertility. Our study aimed to assess action new 1,3,4-oxadiazole derivatives pyrrolo[3,4-d]pyridazinone on rat testes in a model TNBS-induced colitis rats. Methods: current study, from eight randomly chosen rats were taken each following groups: control group (K), (C), groups receiving compounds 7b, 10b, 13b higher doses (20 mg/kg). Results: Colitis did not affect testicular index (expressed as percentage body weight), but 13b, this parameter was than K. No significant differences between noticed malondialdehyde, superoxide dismutase, interleukin-1, or metalloproteinase 9 levels. group, lactate dehydrogenase activity increased; however, administration compound 10b increased when compared K C. Histological evaluation also reveal abnormalities, morphology tissues comparable all groups. Conclusions: The results suggest that exert toxicity.

Language: Английский

Your brain is full of microplastics: are they harming you? DOI Creative Commons

Max Kozlov

Nature, Journal Year: 2025, Volume and Issue: 638(8050), P. 311 - 313

Published: Feb. 11, 2025

Language: Английский

Citations

0
Human external and internal exposure to micro(nano)plastics DOI

Guyu Peng

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Citations

0
Biocatalytic recycling of plastics: facts and fiction DOI Creative Commons
Wolfgang Zimmermann

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Enzymatic recycling of plastic waste is attracting considerable attention as a novel strategy to advance circular economy. While currently limited polyesters, achieving economically viable biocatalytic processes remains key challenge.

Language: Английский

Citations

0
Megatrends and emerging issues: Impacts on food safety DOI Creative Commons

Margaret Thorsen,

Jeremy P. Hill, Jeffrey M. Farber

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(3)

Published: April 4, 2025

The world is changing at a pace, driven by global megatrends and their interactions. Megatrends, including climate change, the drive for sustainability, an aging population, urbanization, geopolitical tensions, are producing increasingly challenging environment provision of safe secure food supply. To ensure robust, safe, supply all, potential safety impacts associated with these need to be understood, mitigation management plans must implemented. This paper outlines relevant megatrends, discusses impact on safety, suggests steps help production in future. Megatrends driving resource depletion, reducing vitality plants animals, increasing geographical spread animal plant pathogens, risk mycotoxins, agrichemical residues, antimicrobial-resistant pathogens contaminating foods, threatening destabilize systems regulatory network. Science-based actions, adopting continual dynamic assessments, alongside use more sensitive accurate methods detection contaminants, may counter challenges. artificial intelligence, robotics automation, enhancement cultures, continued education training workforces, implementation risk-based regulations will preventative controls place. As low-income countries smallholder farmers likely exposed less have resources them, social inequality, unrest, population migration exacerbated unless urgent action taken.

Language: Английский

Citations

0
1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity DOI Creative Commons
Anna Merwid‐Ląd, Piotr Ziółkowski, Beata Nowak

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 546 - 546

Published: April 8, 2025

Background/Objectives: Inflammatory bowel disease significantly impairs the patient’s quality of life. In young individuals, both and drugs used for treatment may impact fertility. Our study aimed to assess action new 1,3,4-oxadiazole derivatives pyrrolo[3,4-d]pyridazinone on rat testes in a model TNBS-induced colitis rats. Methods: current study, from eight randomly chosen rats were taken each following groups: control group (K), (C), groups receiving compounds 7b, 10b, 13b higher doses (20 mg/kg). Results: Colitis did not affect testicular index (expressed as percentage body weight), but 13b, this parameter was than K. No significant differences between noticed malondialdehyde, superoxide dismutase, interleukin-1, or metalloproteinase 9 levels. group, lactate dehydrogenase activity increased; however, administration compound 10b increased when compared K C. Histological evaluation also reveal abnormalities, morphology tissues comparable all groups. Conclusions: The results suggest that exert toxicity.

Language: Английский

Citations

0