PFAS: The Journey from Wonder Chemicals to Environmental Nightmares and the Search for Solutions DOI Creative Commons

Duwage C. Perera,

Jay N. Meegoda

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8611 - 8611

Published: Sept. 24, 2024

Per- and polyfluoroalkyl substances (PFAS) are diverse synthetic chemicals manufactured over seven decades. It is an aliphatic molecule with a basic hydrophobic structure of carbon fluorine linked to hydrophilic end group. Due their physicochemical properties associated the unique structure, PFAS has been used in wide variety applications including aqueous film-forming foams (AFFF), paper, carpets, non-stick cookware, etc. as they make products resistant water, heat, stains. These molecules have drawn great attention recently for properties, high stability low degradability, so-called “Forever Chemicals”. strongest carbon-fluorine bond which makes them persistent environment. Hence it contaminates natural resources endangers public health. This review discusses discovery, development, evolution from wonder chemical era nightmare era, exposure its impacts on human health environment, current remediation techniques, future trends related products. The primary objective this identify knowledge gaps contamination, methods, possible alternatives.

Language: Английский

Efficient removal of per- and polyfluoroalkyl substances by a metal-organic framework membrane with high selectivity and stability DOI
Kunpeng Zhang, Peng Cheng, Yanling Liu

et al.

Water Research, Journal Year: 2024, Volume and Issue: 265, P. 122276 - 122276

Published: Aug. 15, 2024

Language: Английский

Citations

7
Fluorine-fluorine interaction-driven colorimetric sensor for PFOA-sensitive detection using F-functionalized Ce-UiO-66-NH2 MOF with oxidase-like activity DOI

Nairong Yang,

Xinyu Lin, Xiaomei Zheng

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Electrochemical Sensing of Perfluorooctanoic Acid via a Rationally Designed Fluorine-Functionalized Cu-MOF and In-Depth Analysis of Sensing Mechanism DOI
Xuan Zheng,

Cun Li,

Nairong Yang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Perfluorooctanoic acid (PFOA), a prominent member of the per- and polyfluoroalkyl substance (PFAS) family, has emerged as new perpetual pollutant posing significant environmental health risks, necessitating developing highly selective materials for its sensitive detection in water. In this work, we developed an electroactive fluorine-functionalized Cu-MOF (F-Cu-NH2BDC) through postmodification copper-2-amino-terephthalic (Cu-NH2BDC) MOF with 2,3,5,6-tetrafluoroterephthalaldehyde (TFTA). Experimental computational results suggested that F-F interactions between decorated tetrafluorobenzaldehyde groups PFOA, well among PFOA molecules themselves, would induce self-aggregation on surfaces or pores F-Cu-NH2BDC. This specific aggregation inhibited contact electron transfer F-Cu-NH2BDC electrolyte, resulting decrease inherent electrochemical Cu2+/Cu+ redox signal from Based this, F-Cu-NH2BDC-based label- probe-free sensor was exploited excellent linear range 5 pM to 500 μM extremely low limit 3.54 pM, surpassing most currently reported nonelectrochemical PFAS sensors. also exhibited good stability, reproducibility, anti-interference performance, enabling accurate measurement concentrations actual commercial drinking These findings shed light design sensors utilizing interaction working mechanism.

Language: Английский

Citations

0
Unraveling the Exposure Spectrum of PFAS in Fluorochemical Occupational Workers: Structural Diversity, Temporal Trends, and Risk Prioritization DOI
Yanna Liu, Yunhe Guo,

Meilin Lv

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Despite extensive poly/perfluoroalkyl substance (PFAS) discovery studies in various samples, the exposure spectrum fluorochemical occupational workers remains largely unexplored. Here, serum samples from 28 at a facility were analyzed using nontarget techniques, identifying 64 PFAS classes, including 15 novel ones such as pentafluorosulfur ether-substituted perfluoroalkyl sulfonic acids, hydrogen-substituted perfluoroalkylamines, and perfluoroalkylsulfonyl protocatechualdehyde esters. Temporal trend analyses (2008–2018) revealed stable levels for most but an increase perfluorobutanoic acid (PFBA) perfluorohexanesulfonic (PFHxS), suggesting industrial shifts long-chain to short-chain homologues China since early 2010s. Commonly reported structurally modified (e.g., hydrogen/carbonyl/chlorine substitution, ether insertion, unsaturation) likely historical byproducts of legacy production rather than intentionally manufactured alternatives. A Toxicological Priority Index-based risk assessment, integrating mobility, persistence, bioaccumulation indices, identified di(perfluoroakyl sulfonyl)imides, acids/carboxylic perfluoroalkylsulfonamidoacetic acids high-risk chemicals. Overall, exhibited higher mobility lower persistence PFAS, except chlorinated variants, which showed increased potential. This study highlights critical gaps historically emitted emphasizes need large-scale monitoring assessments manage emerging PFAS.

Language: Английский

Citations

0
An updated overview of nanoparticle-induced cardiovascular toxicity DOI Creative Commons
Haijun Zhu, Lihua Dai, Fei Wang

et al.

Nanotechnology Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 1, 2025

Abstract The cardiovascular system is pivotal in the systemic distribution and toxicity of nanoparticles (NPs) upon their entry into circulation. Therefore, it crucial to extensively investigate adverse effects NPs. This review presents advancements understanding NPs potential effects, particularly humans. We first discussed uptake tissues cells, which result outcomes such as hemolysis, blood coagulation dysfunction, vascular endothelial damage, cardiac pathological damage function impairment. Additionally, we discuss current mechanisms underlying NP-induced toxicity, including oxidative stress, inflammation, mitochondrial autophagy. Moreover, systematically reviewed factors influencing circulation, retention, clearance, within system, include primary physicochemical properties NPs, modifications with biological molecules, physiological conditions body, interaction other environmental chemicals. Finally, proposed challenges associated NP aim providing insights interactions between components offering valuable perspectives for development safer NP-based therapies biomedical applications.

Language: Английский

Citations

0
PFAS: The Journey from Wonder Chemicals to Environmental Nightmares and the Search for Solutions DOI Creative Commons

Duwage C. Perera,

Jay N. Meegoda

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8611 - 8611

Published: Sept. 24, 2024

Per- and polyfluoroalkyl substances (PFAS) are diverse synthetic chemicals manufactured over seven decades. It is an aliphatic molecule with a basic hydrophobic structure of carbon fluorine linked to hydrophilic end group. Due their physicochemical properties associated the unique structure, PFAS has been used in wide variety applications including aqueous film-forming foams (AFFF), paper, carpets, non-stick cookware, etc. as they make products resistant water, heat, stains. These molecules have drawn great attention recently for properties, high stability low degradability, so-called “Forever Chemicals”. strongest carbon-fluorine bond which makes them persistent environment. Hence it contaminates natural resources endangers public health. This review discusses discovery, development, evolution from wonder chemical era nightmare era, exposure its impacts on human health environment, current remediation techniques, future trends related products. The primary objective this identify knowledge gaps contamination, methods, possible alternatives.

Language: Английский

Citations

3