Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172306 - 172306

Published: April 7, 2024

Language: Английский

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Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108677 - 108677

Published: April 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Language: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134598 - 134598

Published: May 13, 2024

Language: Английский

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Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142499 - 142499

Published: May 31, 2024

Language: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175057 - 175057

Published: July 26, 2024

Language: Английский

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Exposure to 6-PPD quinone enhances glycogen accumulation in Caenorhabditis elegans

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124600 - 124600

Published: July 22, 2024

Language: Английский

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Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142975 - 142975

Published: July 29, 2024

Language: Английский

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Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 964, P. 178626 - 178626

Published: Jan. 24, 2025

Language: Английский

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6-PPD quinone at environmentally relevant concentrations induced damage on longevity in C. elegans: Mechanistic insight from inhibition in mitochondrial UPR response

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176275 - 176275

Published: Sept. 13, 2024

Language: Английский

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