2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways DOI Creative Commons
Clare Hsu, Jiahao Zeng, Long Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117173 - 117173

Published: Oct. 14, 2024

Language: Английский

Estrogenic and anti-estrogenic assessment of the flame retardant, 2‐ethylhexyl diphenyl phosphate (EHDPP), and its metabolites: Evidence from in vitro, in silico, and transcriptome studies DOI
Phum Tachachartvanich, Rapeepat Sangsuwan,

Sornsawan Duangta

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137303 - 137303

Published: Jan. 21, 2025

Language: Английский

Citations

1
EHDPP impairs intestinal microbiota homeostasis and induces placental injury through choline mediated gut-placenta axis DOI

Ting Du,

Saifei Lei,

Zhengyao Huang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137573 - 137573

Published: Feb. 19, 2025

Language: Английский

Citations

1
2-Ethylhexyl Diphenyl Phosphate Induces Autism Spectrum Disorder-Like Behaviors in Offspring Mice by Disrupting Postsynaptic Development DOI

Xianlei Jiang,

Chenke Xu, Cheng Xu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(37), P. 16347 - 16356

Published: Sept. 5, 2024

As organophosphorus flame retardants (OPFRs) are constantly detected in human samples, the neurotoxicity of OPFRs is concern. In this study, pregnant ICR mice were exposed to 2-ethylhexyl diphenyl phosphate (EHDPP) drinking water from gestation lactation investigate its effects on autism spectrum disorder-like (ASD-like) behaviors offspring. Serum EHDPP concentrations dams 0.4, 2, and 10 mg/kg groups 0.282 ± 0.051, 0.713 0.115, 0.974 0.048 ng/mL, respectively, within concentration range humans. At highest dose, exposure induced ASD-like both female male Significant reductions mature dendritic spines structural damage postsynaptic density zone noted all but lowest groups, indicating membrane impairment. Mechanistically, significantly downregulated disc large MAGUK scaffold protein 4 expression by inhibiting kinase B type 1 insulin-like growth factor receptor phosphorylation. heterologous synapse formation assay

Language: Английский

Citations

1
Gestational exposure to organophosphate esters and autism spectrum disorder and other non-typical development in a cohort with elevated familial likelihood DOI
Jeong Weon Choi, Jiwon Oh, Deborah H. Bennett

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 263, P. 120141 - 120141

Published: Oct. 11, 2024

Language: Английский

Citations

1
2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways DOI Creative Commons
Clare Hsu, Jiahao Zeng, Long Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117173 - 117173

Published: Oct. 14, 2024

Language: Английский

Citations

1