Physiological Reports,
Journal Year:
2024,
Volume and Issue:
12(22)
Published: Nov. 1, 2024
Abstract
It
is
important
to
understand
the
effects
of
environmental
factors
such
as
air
pollution
on
mitochondrial
structure
and
function,
especially
when
these
changes
increase
cardiovascular
disease
risk.
Although
lifestyle
choices
directly
determine
many
diseases,
increasingly,
it
becoming
clear
that
function
mitochondria
may
be
affected
by
pollutants
found
in
atmosphere
(e.g.,
gases,
pesticides
herbicide
aerosols,
or
microparticles).
To
date,
role
agents
potential
impact
fitness
neglected.
Here
we
offer
a
review
airborne
stressors
pollutants,
contribute
impairments
cause
heart
disease.
Cancer Nanotechnology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 17, 2025
Emphasizing
the
significance
of
cancer-associated
fibroblasts
(CAFs),
non-malignant
yet
pivotal
players
within
tumor
microenvironment
(TME),
this
review
illuminates
role
inflammatory
subtype
(iCAF)
as
catalysts
in
cancer
proliferation,
metastasis,
and
therapeutic
resistance.
Given
their
paramount
importance,
targeting
CAFs
emerges
a
robust
strategy
evolving
landscape
immunotherapy.
Nanomaterials,
distinguished
by
unique
features
malleability,
hold
considerable
promise
biomedicine,
especially
precision-oriented
domain
therapy.
Their
aptitude
for
modulating
immune
responses,
amplifying
drug
efficacy
through
precise
delivery,
discerningly
focusing
on
cells
TME
situates
nanomaterials
formidable
tools
to
transcend
boundaries
set
conventional
treatments.
This
scrutinizes
convoluted
interplay
among
CAFs,
cells,
TME.
It
further
showcases
widely
utilized
management.
We
underscore
potential
nanoscale
delivery
systems
directed
at
underscoring
transformative
power
revolutionizing
therapies,
enhancing
precision,
culminating
improved
patient
outcomes.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
To
explore
the
intergenerational
cardiotoxicity
of
nanoplastics,
maternal
mice
were
exposed
to
60
nm
polystyrene
nanoplastics
(PS-NP)
during
pregnancy
and
lactation.
The
results
showed
that
PS-NP
can
enter
hearts
offspring
induce
myocardial
fiber
arrangement
disorder,
acidophilic
degeneration
cardiomyocytes,
elevated
creatine
kinase
isoenzymes
(CK-MB)
lactate
dehydrogenase
(LDH)
levels
after
exposure
at
100
mg/kg
Mechanistically,
KEGG
analysis
RNA
sequencing
participation
hypoxia-inducible
factor-1
(HIF-1)
ferroptosis
in
PS-NP-induced
cardiotoxicity.
Key
features
ferroptosis,
including
Fe2+
accumulation,
mitochondrial
injury,
oxidative
stress,
GPX4
downregulation,
FTH1,
ACSL4,
SLC7A11
upregulation,
detected.
Furthermore,
treatment
upregulated
expressions
HIF-1α
HO-1,
be
alleviated
by
inhibition
using
si-HIF-1α.
This
study
provided
an
insightful
reference
for
assessment
PS-NP.
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
489, P. 137624 - 137624
Published: Feb. 19, 2025
Microplastics
and
nanoplastics
(MNPs)
have
implicated
in
cardiovascular
disease
preclinical
studies.
Our
objective
is
to
investigate
the
relationship
between
MNPs
coronary
arteries
major
adverse
cardiac
events
(MACE)
patients
with
myocardial
infarction
(MI).We
conducted
a
prospective
observational
study
involving
undergoing
angiography
for
MI.
Coronary
blood
samples
were
analyzed
presence
of
using
pyrolysis-gas
chromatography-mass
spectrometry.
A
total
142
enrolled,
110
completing
31.5-month
follow-up.
Among
them,
48
(43.6
%)
had
detectable
polystyrene,
79
(71.8
polyethylene,
105
(95.4
polyvinyl
chloride
(PVC),
68
(61.8
polyamide
66
their
blood.
PVC
concentration
was
higher
who
experienced
MACE.
Furthermore,
levels
positively
associated
proinflammatory
factors
(IL-1β,
IL-6,
IL-18,
TNF-α),
odds
MACE
(OR:
1.090,
95
%CI:
1.032-1.1523,
P
=
0.002).
Notably,
each
10-unit
increase
PVC,
there
1.374-fold
risk
(OR=2.374,
1.366-4.128,
Additionally,
we
collected
thrombus
from
an
additional
21
MI
patients,
finding
that
thrombi
correlated
inflammatory
markers
monocyte/macrophage
infiltration.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(14), P. 5779 - 5792
Published: Oct. 21, 2024
The
escalation
of
plastic
pollution
represents
a
global
environmental
and
health
problem.
Important
toxic
effects
have
been
attributed
to
the
increasing
diffusion
microplastics
(MPs)
nanoplastics
(NPs)
derived
from
degradation
plastics.
These
particles
ubiquitously
observed
in
environment,
with
humans
being
continuously
exposed
via
ingestion,
inhalation
skin
contact.
Nonetheless,
cellular
homeostasis
imbalance
induced
by
micro-
nano-
plastics
(MNPs)
human
has
only
recently
shown,
while
most
evidence
molecular
mechanisms
studies
Microplastics,
Journal Year:
2024,
Volume and Issue:
3(4), P. 559 - 588
Published: Sept. 30, 2024
Environmental
pollution
from
plastics
has
become
one
of
the
biggest
concerns
globally.
Microplastics
(MPs)
are
plastic
materials
less
than
5
mm
in
size.
They
remain
environment
for
hundreds
to
thousands
years
without
degrading,
only
breaking
down
further
nanoplastics
(NPs).
Micro-
and
can
be
origin
many
diseases
carry
various
pathogenic
substances
on
their
surface
spread
them
throughout
biosphere,
starting
with
contained
additives
ending
adsorbed
toxins
potentially
microorganisms.
Exposure
routes
humans
animals
through
air,
water
food/feed.
Due
placement
livestock—including
ruminants,
fish
poultry—and
at
top
food
web,
any
water,
air
or
soil
eventually
transferred
livestock
humans.
The
presence
microplastics
intestines
aquaculture
species,
ruminants
poultry,
instance,
was
found
cause
a
change
intestinal
microbial
population
and,
as
result,
occurrence
diseases.
These
particles
have
also
been
observed
other
organs
such
liver,
kidneys,
lung,
spleen,
heart,
ovaries,
testicles
animals,
which
causes
biochemical
changes,
structural
destruction,
malfunction.
While
complete
extent
negative
health
impacts
remains
still
largely
unknown,
ubiquitous
transmission
chemicals
organisms
is
notable
issue,
underscoring
importance
gaining
more
comprehensive
understanding
potential
threats
posed
by
animal
ultimately
human
health,
coupled
need
drastic
reduction
freight
into
environment.
This
review
article
summarizes
recent
findings
effect
micro-
farmed
ultimately,
Action
needed
reduce
number
thereby
humans,
exposed.
