Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases DOI Creative Commons

Taiwei Jiao,

Y. Chen,

Haiyan Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107370 - 107370

Published: Aug. 23, 2024

Ferroptosis, an emerging paradigm of programmed cellular necrosis posited in recent years, manifests across a spectrum maladies with profound implications for human well-being. Numerous investigations substantiate that modulating ferroptosis, whether through inhibition or augmentation, plays pivotal role the etiology and control numerous age-related afflictions, encompassing neurological, circulatory, respiratory, other disorders. This paper not only summarizes regulatory mechanisms but also discusses impact ferroptosis on biological processes aging its diseases. Furthermore, it scrutinizes therapeutic strides addressing aging-related conditions modulation ferroptosis. The consolidates existing knowledge potential applications ferroptosis-related pharmacotherapies envisages translational prospects ferroptosis-targeted interventions clinical paradigms.

Language: Английский

Unraveling the Differential Tolerance Mechanisms of Acropora formosa and Montipora digitata to Benzo[a]pyrene (BaP) Exposure via 4D Proteomics DOI
Kai Yin, Xin Zhang,

Yuebin Pei

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138213 - 138213

Published: April 8, 2025

Language: Английский

Citations

0
Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases DOI Creative Commons

Taiwei Jiao,

Y. Chen,

Haiyan Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107370 - 107370

Published: Aug. 23, 2024

Ferroptosis, an emerging paradigm of programmed cellular necrosis posited in recent years, manifests across a spectrum maladies with profound implications for human well-being. Numerous investigations substantiate that modulating ferroptosis, whether through inhibition or augmentation, plays pivotal role the etiology and control numerous age-related afflictions, encompassing neurological, circulatory, respiratory, other disorders. This paper not only summarizes regulatory mechanisms but also discusses impact ferroptosis on biological processes aging its diseases. Furthermore, it scrutinizes therapeutic strides addressing aging-related conditions modulation ferroptosis. The consolidates existing knowledge potential applications ferroptosis-related pharmacotherapies envisages translational prospects ferroptosis-targeted interventions clinical paradigms.

Language: Английский

Citations

3