Explore the toxicological mechanism of 6PPD-Q on human health through a novel perspective: The interaction between lactate dehydrogenase and 6PPD-Q DOI

Lin Kuang,

Xi Wang,

Zimeng He

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139266 - 139266

Published: Dec. 1, 2024

Language: Английский

Environmental Concentrations of 6PPD and 6PPD-Quinone Induce Hepatic Lipid Metabolism Disorders in Male Black-Spotted Frogs DOI
Zhiquan Liu,

Yixuan Feng,

Wenhui Sun

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136400 - 136400

Published: Nov. 4, 2024

Language: Английский

Citations

11
Effects of Biochar on Tire Wear Particle-Derived 6PPD, 6PPD-Q, and Antimony Levels and Microbial Community in Soil DOI
Stanley Chukwuemeka Ihenetu,

Yilong Hao,

Jun Ma

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137951 - 137951

Published: March 1, 2025

Language: Английский

Citations

1
Multigenerational toxic effects in Daphnia pulex are induced by environmental concentrations of tire wear particle leachate DOI
Zhiqun Liu, Guanghui Wang,

Xixi Ye

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 136977 - 136977

Published: Dec. 24, 2024

Language: Английский

Citations

5
Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells DOI Creative Commons
Jong Geol Lee, Seon Min Lee, Moonjung Hyun

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117744 - 117744

Published: Jan. 1, 2025

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a synthetic additive widely used in the rubber industry, and its oxidized product 6PPD-quinone (6PPDQ), have garnered widespread attention as an emerging hazardous chemicals owing to their potential detrimental effects on aquatic ecosystem human health. The of 6PPD 6PPDq female reproductive tract, especially embryo implantation, remain unknown were investigated this study. We spheroid attachment outgrowth models BeWo trophoblastic spheroids Ishikawa cells surrogates for blastocyst endometrial epithelium, respectively. Treatment with up 48 h decreased viability dose- cell line-dependent manner (20-100 μM 10-100 6PPDQ both lines). At noncytotoxic concentration, exposure 1 10 reduced further inhibited invasion epithelial monolayer. A similar result was observed 6PPDQ-exposed groups. Gene expression profiling 6PPD- revealed that differentially regulated panel transcript markers toward overall downregulation receptivity invasion. study provides first proof adverse trophoblast during window warranting need vivo clinical studies.

Language: Английский

Citations

0
Molecular insight on conformational alterations and functional changes of acetylcholinesterase induced by an emerging environmental pollutant 6PPD-quinone DOI

Yue Zhang,

Shuyuan Zhang, Yiming Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141205 - 141205

Published: Feb. 17, 2025

Language: Английский

Citations

0
Residues of 6PPD-Q in the Aquatic Environment and Toxicity to Aquatic Organisms: A Review DOI Creative Commons

Chaoju Li,

Yuanqiang Yang,

Zhen Tian

et al.

Fishes, Journal Year: 2025, Volume and Issue: 10(4), P. 146 - 146

Published: March 25, 2025

N-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone (6PPD-Q) is an emerging environmental contaminant that widely distributed in aquatic environments and presents significant toxicological risks to organisms. As 6PPD-Q primarily derived from oxidative transformation of the tire antioxidant N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD), its persistence potential for bioaccumulation organisms have raised widespread concerns. This study reviews sources, spatial distribution, migration, behaviors 6PPD-Q, as well degradation mechanisms different media. Additionally, this review systematically explores effects on organisms, including physiological, biochemical, molecular impacts fish, crustaceans, mollusks, algae, with a focus mechanisms. Finally, we discuss limitations current research propose key directions future studies, long-term ecological risk assessments, bioaccumulation, metabolic pathway analysis, optimization pollution control strategies, aiming provide scientific basis assessment management 6PPD-Q.

Language: Английский

Citations

0
A bibliometric analysis of global research hotspots and progress on emerging environmental pollutants 6PPD and 6PPD-quinone from 2004 to 2024 DOI Creative Commons

S. Babaei,

Febelyn Reguyal, Ajit K. Sarmah

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124969 - 124969

Published: Sept. 1, 2024

Language: Английский

Citations

3
Phytotoxicity of 6PPD and its uptake by Myriophyllum verticillatum: Oxidative stress and metabolic processes DOI

Yuexing Zhao,

Weitao Liu,

Jinzheng Liu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 177248 - 177248

Published: Nov. 1, 2024

Language: Английский

Citations

2
Response of Ceratophyllum demersum L. and its epiphytic biofilms to 6PPD and 6PPD-Q exposure: Based on metabolomics and microbial community analysis DOI
Xiang Li, Weitao Liu,

Yichen Ge

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136420 - 136420

Published: Nov. 5, 2024

Language: Английский

Citations

1
Chronic toxicity and intergenerational effects of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) exposure alone and in combination with Zn2+ on Daphnia magna (Cladocera) DOI
Yang Liu, Kexin Liu, Lina Shi

et al.

Ecotoxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations

0