Cited by Cleaner cuts: Farmed fish and skin-off fillets are lower in per- and polyfluoroalkyl substances (PFAS)

Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States DOI

Shiwen Li,

Paulina Oliva,

Lu Zhang

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Background Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water cancers can help inform biomonitoring prevention efforts. Objective To screen for incident cancer (2016–2021) assess associations contamination the US. Methods We obtained county-level age-adjusted incidence from Surveillance, Epidemiology, End Results (SEER) Program. Data on levels public systems were Third (UCMR3; 2013–2015) Fifth (UCMR5; 2023–2024) Unregulated Contaminant Monitoring Rule. UCMR3 measured PFOS, PFOA, PFNA, PFHxS, PFHpA, PFBS. UCMR5 expanded measurements include PFBA, PFHxA, PFPeA, PFPeS. created indicators detection and, UCMR5, concentrations above Maximum Levels (MCLs). MCLs PFOA PFOS are 4 ng/L, PFNA PFHxS 10 ng/L. used Poisson regression models between or MCL violation incidence, adjusting potential confounders. estimated number attributable cases. was associated increased digestive, endocrine, oral cavity/pharynx, respiratory systems. Incidence rate ratios (IRRs) ranged 1.02 1.33. The strongest association observed PFBS cavity/pharynx (IRR: 1.33 [1.04, 1.71]). Among males, urinary, brain, leukemia, soft tissues. females, thyroid, tissue. is contribute 4626 [95% CI: 1,377, 8046] cases per year based data 6864 991, 12,804] UCMR5. Impact statement ecological study examined two waves (2013–2015 2016 2021. found that organ system including lung, digestive system, urinary tissue, thyroid. Some have not widely studied their PFAS. also sex differences risks. This first exposure

Language: Английский

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Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning DOI

Fei Wang, Yuanxin Lin, Qin Lian

et al.

Environment International, Journal Year: 2024, Volume and Issue: 195, P. 109203 - 109203

Published: Dec. 11, 2024

Language: Английский

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The Environmental Impact of Medical Imaging Agents and the Roadmap to Sustainable Medical Imaging DOI

Verena Pichler, Ricardo P. Martinho,

Lisanne Temming

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Medical imaging agents, i.e., contrast agents for magnetic resonance (MRI) and radiopharmaceuticals, play a vital role in the diagnosis of diseases. Yet, they mostly contain harmful non‐biodegradable substances, such as per‐ polyfluoroalkyl substances (PFAS), heavy metals or radionuclides. As result their increasing clinical use, these are entering various water bodies soil, posing risks to environment human health. Here, environmental effects application outlined major modalities, respective chemistry with implications is linked. Recommendations introduced design agents: 3Cs control, change, combine; recent approaches more sustainable strategies highlighted. This combination measures should engage an open discussion, inspire solutions reduce pollution by increase awareness impact toxic waste related agents.

Language: Английский

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Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review DOI

Csilla Mišľanová, Martina Valachovičová

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 573 - 573

Published: April 1, 2025

Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential

Language: Английский

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PFHxA and PFHxS promote breast cancer progression in 3D culture: MEX3C-associated immune infiltration revealed by bioinformatics and machine learning DOI

Huan Wang,

Guangming Xie,

Zhijin Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138458 - 138458

Published: May 2, 2025

Language: Английский

Citations

Cleaner cuts: Farmed fish and skin-off fillets are lower in per- and polyfluoroalkyl substances (PFAS) DOI

Guillermo Figueroa‐Muñoz, C. Murphy,

Kory A. Whittum

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 959, P. 178266 - 178266

Published: Dec. 29, 2024

Language: Английский

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