BMC Chemistry,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Aug. 3, 2024
Developing
analytical
techniques
that
align
with
green
and
sustainable
chemistry
principles
is
crucial
in
today's
scientific
landscape.
This
work
introduces
two
innovative
approaches
for
the
simultaneous
quantification
of
indacaterol
(IND)
mometasone
(MOM),
a
recently
approved
combination
therapy
chronic
obstructive
pulmonary
disease.
These
methods-rapid
isocratic
ion
pair
chromatography
(IPC)
UV-visible
spectrophotometry-demonstrate
improved
environmental
sustainability,
cost-effectiveness,
versatility
compared
to
existing
techniques.
The
optimized
4-min
IPC
method
achieved
excellent
resolution
(retention
times
2.18
±
0.1
min
IND
3.95
MOM),
peak
symmetry,
sensitivity.
It
utilizes
low-cost
mobile
phase
acetonitrile
acidified
water
containing
0.025%
sodium
dodecyl
sulfate
(50:50%
v/v),
making
it
suitable
laboratories
standard
chromatographic
instruments.
spectrophotometric
approach
offers
procedures:
first
derivative
ratio
methods.
serve
as
simplified,
alternatives
resource-limited
without
access
advanced
Both
feature
simplified
protocols
minimize
extraction
fractionation
steps.
Comprehensive
validation
confirmed
outstanding
accuracy
(98-102%)
precision
(%2
<).
Sustainability
assessments
using
ComplexGAPI,
AGREE,
carbon
footprint,
BAGI,
RGB12
tools
demonstrated
enhanced
performance
spectrophotometry
methods
greenness
scores
0.81
0.85,
respectively,
surpassing
0.63-0.67
range
reported
Additionally,
they
showed
lower
footprints
0.035
0.022
kg
CO2
equivalent
emissions
per
sample,
0.079-0.092
conventional
procedures.
application
novel
"blueness"
"whiteness"
concepts
BAGI
algorithms
further
superior
87.5
&
90
blueness
88.1
89.8
whiteness.
Successfully
applied
quantify
MOM
combined
capsules,
this
provides
model
eco-friendly
pharmaceutical
analysis
maintains
high
reliability
while
improving
sustainability
metrics.
Green Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
9, P. 100108 - 100108
Published: March 24, 2024
Introduction:
Sustainable
analytical
practices
can
be
made
by
considering
several
parameters
such
as
eco-friendliness,
productivity,
practicality
along
with
the
method
performance.
Environmentally
destructive
research
practices,
using
and
releasing
hazardous
solvents
reagents
into
atmosphere,
have
brought
up
serious
concerns
regarding
ecological
impact
of
these
actions.
By
checking
greenness
methods
challenges
minimized.
It
gives
a
brief
idea
about
its
extent
effect
on
environment
to
analyst.
On
other
side
sustainability
assessed
white
metrics
RGB
color
model.
A
new
tool
called
BAGI
was
emerged
for
Objective:
This
work
designed
select
sustainable
estimation
amlodipine
besylate
telmisartan
from
existing
UV
spectroscopy
methods.
Methodology:
In
this
available
estimate
two
drugs
UV-spectroscopy
are
collected
in
terms
their
greenness,
whiteness
blueness
variety
like
GAPI,
12
algorithm
BAGI.
The
degree
selected
were
shown
pictograms
some
scores
cases
assessment
tools.
results
tabulated
compared
best
choice.
Conclusion:
study
gave
clear
pros
cons
respect
green,
blue
aspects
it
easy
analyst
BioChip Journal,
Journal Year:
2024,
Volume and Issue:
18(2), P. 257 - 274
Published: March 8, 2024
Abstract
Veterinary
drug
residues
in
food
have
emerged
as
an
urgent
threat
to
consumer
safety.
Herein,
we
present
the
first
square
wave
voltammetric
method
for
trace-level
detection
of
cinnarizine
residues,
a
recently
used
antischistosomal
drug,
bovine
samples.
The
depends
on
electrochemical
oxidation
after
modification
carbon
paste
sensor
with
recycled
Al
2
O
3
-NPs
functionalized
multi-walled
nanoparticles.
produced
(Al
-NPs/
MWCNTs/CPE)
was
characterized
using
transmission
electron
microscope,
scanning
Fourier-transform
infrared
spectroscopy,
energy-dispersive
spectrometer,
and
X-ray
diffractometer
that
confirm
successful
incorporation
-NPs/MWCNTs
composite
into
modified
electrode.
As
expected,
active
surface
area
transfer
processes
were
accelerated
by
modification,
which
evidenced
cyclic
voltammetry,
chronoamperometric
studies,
scan
rate
impedance
spectroscopy.
Compared
previous
techniques,
this
facile
demonstrated
enhancements
across
critical
analytical
criteria
including
limit
0.17
nM,
linear
response
5–100
nM
(
r
=
0.998),
accuracy
ranging
from
96.5
103.2%,
precision
below
0.81%
relative
standard
deviation,
reproducibility
within
0.36%
range,
20
s
time
applicability
spiked
matrices.
In
addition,
five
different
greenness
whiteness
tools
quantified
exceptional
environmental
friendliness,
economic
feasibility
waste
reduction
63%–93%,
reaffirming
alignment
sustainability
paradigms.
These
advantages
support
practical
adoption
quality
control
especially
laboratories
lacking
expensive
instrumentation.
Overall,
ingenious
reconciles
nanotechnology
innovation
circular
economy
ethos
tackle
safety
challenge,
guided
holistically
metrics.
BMC Chemistry,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Aug. 9, 2024
The
development
of
sustainable
analytical
methodologies
that
minimize
hazards,
waste
generation,
and
energy
consumption
has
become
crucial.
This
study
introduces
pioneering
green‒blue-white
approaches
for
the
simultaneous
quantification
montelukast
sodium
(MLK)
fexofenadine
hydrochloride
(FEX)
in
combination
formulations.
first
approach
employs
an
ultra-performance
liquid
chromatographic
method
(UPLC)
with
a
green
micellar
mobile
phase
0.02
M
dodecyl
sulfate
10%
1-pentanol
(65:35%).
demonstrated
excellent
resolution,
peak
symmetry,
short
analysis
time,
retention
times
3.53
min
MLK
1.67
FEX.
FEX
linearities
were
1-260
1.2-312
μg/mL,
respectively.
second
involves
complementary
built-in
spectroscopic
techniques
(second
derivative,
third
ratio
difference
methods)
using
water
as
solvent,
providing
green,
simple,
low-cost
alternative
laboratories
where
expensive
devices
may
not
be
readily
available.
3-50
3-60
All
methods
comprehensively
validated
showed
satisfactory
results.
proposed
linearity
(r
