RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(28), P. 19658 - 19679
Published: Jan. 1, 2024
The
introduction
of
favipiravir
as
a
broad-spectrum
antiviral
agent,
particularly
in
treating
influenza
and
exploring
its
potential
against
COVID-19,
emphasizes
the
necessity
for
efficient
analytical
methods.
BMC Chemistry,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Oct. 17, 2024
Novel
univariate
and
chemometrics-aided
UV
spectrophotometric
methods
were
tailored
to
undergo
the
fundamentals
of
green
white
analytical
chemistry
for
simultaneous
estimation
a
ternary
mixture
olanzapine
(OLA),
fluoxetine
HCL
(FLU),
its
toxic
impurity
4-(Trifluoromethyl)
phenol
(FMP)
without
any
prior
separation.
The
dual-wavelength
ratio
spectrum
method
was
used
determine
OLA
FLU
in
presence
FMP
range
(4-20)
(5-50)
μg/ml,
respectively.
In
compliance
with
International
Conference
on
Harmonization
(ICH)
standards,
technique
validated
established
Remarkable
accuracy
(98-102%)
precision
(<
2%)
limits
quantification
(LOQs)
0.432
2.002
Partial
least
squares
(PLS)
artificial
neural
networks
(ANNs)
are
chemometric
methodologies
that
have
advantages
over
use
significant
innovations
employing
Latin
hypercube
sampling
(LHS),
allowing
generation
reliable
validation
set
guarantee
effectiveness
sustainability
these
models.
concentration
ranges
(2-20),
μg/ml;
PLS,
LOQs
0.602,
0.508,
1.429
root
mean
square
errors
prediction
(RMSEPs)
0.087,
0.048,
0.159
OLA,
FMP,
FLU,
respectively;
ANNs,
0.551,
0.465,
0.965
RMSEPs
0.056,
0.047,
0.087
developed
yield
greener
National
Environmental
Methods
Index
(NEMI)
an
eco-scale
assessment
(ESA)
score
90
complementary
Green
Analytical
Procedure
(complex
GAPI)
quadrants
greenness
metric
(AGREE)
0.8.
Red‒Green-Blue
12
algorithm
(RGB
12)
scored
88.9,
outperforming
reported
demonstrating
widespread
practical
environmental
approval.
Statistical
analysis
revealed
no
noteworthy
differences
(P
>
0.05)
among
proposed
published
techniques.
Both
pure
powders
pharmaceutical
capsules
analyzed
via
methods.
