Chronobiology in Paediatric Neurological and Neuropsychiatric Disorders: Harmonizing Care with Biological Clocks DOI Open Access
Gabriele Giannotta, Marta Ruggiero, Antonio Trabacca

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7737 - 7737

Published: Dec. 18, 2024

Background: Chronobiology has gained attention in the context of paediatric neurological and neuropsychiatric disorders, including migraine, epilepsy, autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), post-traumatic stress (PTSD). Disruptions circadian rhythms are associated with key symptoms such as sleep disturbances, mood dysregulation, cognitive impairments, suggesting a potential for chronobiology-based therapeutic approaches. Methods: This narrative review employs systematic approach to identify relevant studies through searches three major scientific databases, NCBI/PubMed, ScienceDirect, Scopus, up July 2024. We used combination broad condition-specific keywords, “chronobiology”, “biorhythm”, “pediatric”, “epilepsy”, “ADHD”, “ASD”, among others. Articles English that focused on clinical features, treatments, or outcomes related populations were included, while non-peer-reviewed articles lacking original data excluded. Rayyan software was article screening, removing duplicates, facilitating consensus independent reviewers. Results: A total 87 included analysis. Findings reveal consistent pattern rhythm disruptions across disorders examined. Specifically, dysregulation melatonin cortisol secretion is observed children ASD, ADHD, PTSD, altered timing contributing disturbances swings. Alterations core clock genes (CLOCK, BMAL1, PER, CRY) also noted which linked seizure frequency timing. Chronotherapy approaches showed promise managing these disruptions: supplementation improved quality reduced ADHD some children, light therapy proved effective stabilizing sleep–wake cycles ASD patients. Additionally, behaviour-based interventions, Early Start Denver Model, success improving alignment ASD. Conclusions: highlights significant role direct implications treatment. Chronobiology-based therapy, exposure, individualized behavioural therapies, offer symptomatology overall functioning. The integration chronotherapy into practice could provide paradigm shift from symptom management more targeted, rhythm-based treatments. Future research should focus understanding molecular mechanisms behind exploring personalized chronotherapeutic tailored individual patterns.

Language: Английский

Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2 DOI Creative Commons
Sherine Abdelmissih, Sara Adel Hosny, Heba M. Elwi

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Rationale Evidence of the effects chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) quetiapine (QUET), on electroencephalography (EEG), which is relevant to cognition, epileptogenesis, and ovarian function, remains lacking. Estrogenic, adenosinergic, melatonergic signaling possibly linked dynamics these substances. Objectives The brain CAFF were compared those AGO + QUET CAFF. implications estrogenic, brain-ovarian crosstalk investigated. Methods Adult female rats administered (10 mg/kg), CAFF, once daily for 8 weeks. EEG, estrous cycle progression, microstructure ovaries examined. Brain 17β-estradiol (E2), antimullerian hormone (AMH), estrogen receptor alpha (E2Rα), adenosine 2A (A2AR), melatonin 2 (MT2R) assessed. Results combined QUET, reduced maximum EEG peak, was positively E2Rα, negatively correlated cortical neurodegeneration MT2R, associated cystic ovaries. A large corpus luteum emerged antagonizing CAFF-mediated increased A2AR E2Rα. provoked TTP delay AMH, while slowed source frequency δ range E2. Conclusions treatment triggered derangements partially antagonized concurrent administration but no overt affection estrus progression. may explain effects.

Language: Английский

Citations

1
La melatonina nei disturbi del sonno in bambini e adolescenti con problemi neurocomportamentali DOI
Federico Marchetti, Enrico Cocchi

Medico e Bambino, Journal Year: 2024, Volume and Issue: 43(8), P. 505 - 508

Published: Oct. 1, 2024

Melatonin, a neurohormone produced by the pineal gland, regulates sleep-wake circadian rhythm. Sleep disorders are prevalent in children, especially those with neurodevelopmental like autism and other neurodisabilities affect about 50-75% of this population. The use melatonin to improve sleep population has been debated for over 20 years, recent reviews addressing its efficacy safety. Melatonin significantly improves latency total time children spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), disorders. However, effectiveness reducing night awakenings is limited. Short-term shows no significant association serious adverse effects, though mild side effects headache, nausea, drowsiness, mood changes common. Long-term safety data limited but suggest impact on puberty onset or bone health. Dosing timing administration vary widely, individualized treatment plans recommended. should be accompanied behavioural interventions, potential monitored closely.

Language: Английский

Citations

0
Randomised placebo-controlled trial of triclofos versus melatonin for sedating children undergoing sleep EEG DOI

P Mohanan,

Ruchika Jha, Arjun Kurup

et al.

Archives of Disease in Childhood, Journal Year: 2024, Volume and Issue: unknown, P. archdischild - 327416

Published: Nov. 23, 2024

Objective To determine the efficacy of addition melatonin or triclofos to sleep deprivation as compared with placebo for conduct successful electroencephalogram (EEG) among children between 6 months and 12 years age. Design, setting Patients 486 aged who were uncooperative referred EEG enrolled this double-blind, placebo-controlled randomised trial 30 June 2022 31 March 2023. Intervention On day EEG, participants deprived by 25% their regular duration then randomly assigned receive either (50 mg/kg), (weight ≤15 kg=3 mg; weight >15 kg=6 mg) placebo. Outcome Primary outcome was a EEG. Results intervention (n=165), (n=161) (n=160). Sleep success (p<0.001) different interventions was: triclofos=145/165(88%); melatonin=123/161 (76%) placebo=65/160 (41%). EEG’s rate better than (OR=2.2; 95% CI 1.2 4.1) (OR=10.6; 6.1 19.0). Melatonin in (OR=4.7; 2.9 7.7). Beta artefacts significantly more (51/145) (19/123) (12/65), but readability not impacted. Movement/unwanted arousal (37/65) (37/145) (34/123). Drug-related adverse events comparable melatonin. Neither drugs associated any serious events. Conclusions Both are individually alone conducting EEGs. Triclofos is EEGs, no significant increase Trial registration number CTRI/2022/05/042479; Clinical Trials Registry India

Language: Английский

Citations

0
Chronobiology in Paediatric Neurological and Neuropsychiatric Disorders: Harmonizing Care with Biological Clocks DOI Open Access
Gabriele Giannotta, Marta Ruggiero, Antonio Trabacca

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7737 - 7737

Published: Dec. 18, 2024

Background: Chronobiology has gained attention in the context of paediatric neurological and neuropsychiatric disorders, including migraine, epilepsy, autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), post-traumatic stress (PTSD). Disruptions circadian rhythms are associated with key symptoms such as sleep disturbances, mood dysregulation, cognitive impairments, suggesting a potential for chronobiology-based therapeutic approaches. Methods: This narrative review employs systematic approach to identify relevant studies through searches three major scientific databases, NCBI/PubMed, ScienceDirect, Scopus, up July 2024. We used combination broad condition-specific keywords, “chronobiology”, “biorhythm”, “pediatric”, “epilepsy”, “ADHD”, “ASD”, among others. Articles English that focused on clinical features, treatments, or outcomes related populations were included, while non-peer-reviewed articles lacking original data excluded. Rayyan software was article screening, removing duplicates, facilitating consensus independent reviewers. Results: A total 87 included analysis. Findings reveal consistent pattern rhythm disruptions across disorders examined. Specifically, dysregulation melatonin cortisol secretion is observed children ASD, ADHD, PTSD, altered timing contributing disturbances swings. Alterations core clock genes (CLOCK, BMAL1, PER, CRY) also noted which linked seizure frequency timing. Chronotherapy approaches showed promise managing these disruptions: supplementation improved quality reduced ADHD some children, light therapy proved effective stabilizing sleep–wake cycles ASD patients. Additionally, behaviour-based interventions, Early Start Denver Model, success improving alignment ASD. Conclusions: highlights significant role direct implications treatment. Chronobiology-based therapy, exposure, individualized behavioural therapies, offer symptomatology overall functioning. The integration chronotherapy into practice could provide paradigm shift from symptom management more targeted, rhythm-based treatments. Future research should focus understanding molecular mechanisms behind exploring personalized chronotherapeutic tailored individual patterns.

Language: Английский

Citations

0