Tumor acidity: From hallmark of cancer to target of treatment

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Aug. 29, 2022

Tumor acidity is one of the cancer hallmarks and associated with metabolic reprogramming use glycolysis, which results in a high intracellular lactic acid concentration. Cancer cells avoid stress major by activation expression proton lactate transporters exchangers have an inverted pH gradient (extracellular pHs are alkaline, respectively). The shift tumor acid-base balance promotes proliferation, apoptosis avoidance, invasiveness, metastatic potential, aggressiveness, immune evasion, treatment resistance. For example, weak-base chemotherapeutic agents may substantially reduced cellular uptake capacity due to "ion trapping". Lactic negatively affects functions activated effector T cells, stimulates regulatory them express programmed cell death receptor 1. On other hand, inversion could be weakness that will allow development new promising therapies, such as tumor-targeted pH-sensitive antibodies pH-responsible nanoparticle conjugates anticancer drugs. regulation levels pharmacological inhibition proteins (monocarboxylate transporters, H

Language: Английский

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Ready-to-use green polyphenolic extracts from food by-products

Food Chemistry, Journal Year: 2019, Volume and Issue: 283, P. 628 - 636

Published: Jan. 18, 2019

Language: Английский

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The therapeutic importance of acid-base balance

Biochemical Pharmacology, Journal Year: 2020, Volume and Issue: 183, P. 114278 - 114278

Published: Oct. 9, 2020

Language: Английский

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Hybrid Silicon Nanowire Devices and Their Functional Diversity

Advanced Science, Journal Year: 2019, Volume and Issue: 6(15)

Published: June 3, 2019

In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks commercially available electronic devices. Their application areas span from miniaturized elements devices and circuits to ultrasensitive biosensors for diagnostics. this Review, current trends in developments nanowire-based summarized, their functionalities, novel architectures, applications discussed point view analog electronics, arisen ability (bio)chemical gating carrier channel. Hybrid introduced described systems decorated by, e.g., organic complexes (biomolecules, polymers, films), aimed substantially extend functionality, compared traditional systems. functional diversity is explored considering architecture well applications, outlining several groups that benefit coatings. The first group able represent label-free assays thanks attached biological receptors. second represented by optoelectronics acquire higher optical sensitivity or efficiency due specific photosensitive decoration nanowires. Finally, so-called new bioinspired neuromorphic shown, which mimic functions cells, neurons synapses.

Language: Английский

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Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders

Biogerontology, Journal Year: 2020, Volume and Issue: 21(6), P. 683 - 694

Published: July 2, 2020

Language: Английский

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Stimuli-responsive polyelectrolyte multilayer films and microcapsules

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 310, P. 102773 - 102773

Published: Sept. 9, 2022

Polyelectrolyte multilayer (PEM) films and particularly hollow capsules composed of PEM shells have gained significant interest since their introduction. Their compositional versatility easiness preparation via so-called layer-by-layer assembly led to the development numerous systems containing also stimuli-responsive components. This paper reviews achievements related formation, determination structure, properties responding major physical, chemical, biological stimuli. applications as e.g., microcarriers for controlled delivery release active components, substrates cells' growth, coatings enhanced surface adhesion, or self-healing anticorrosive are shown discussed. The influence various stimuli on integrity, permeability shell presented together with in biomedicine drug well biotechnology industrial protective coatings.

Language: Английский

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Dual/Multi-responsive fluorogenic probes for multiple analytes in mitochondria: From design to applications

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 155, P. 116697 - 116697

Published: May 28, 2022

Language: Английский

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Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition

Journal of Cell Science, Journal Year: 2023, Volume and Issue: 136(10)

Published: May 3, 2023

Transient changes in intracellular pH (pHi) regulate normal cell behaviors, but roles for spatiotemporal pHi dynamics single-cell behaviors remain unclear. Here, we mapped during mammalian cycle progression both with and without synchronization. We found that is dynamic throughout the cycle: decreases at G1/S, increases mid-S, late S, G2/M rapidly mitosis. Importantly, although highly dividing cells, non-dividing cells have attenuated dynamics. Using two independent manipulation methods, low inhibits completion of S phase whereas high promotes S/G2 transitions. Our data also suggest cues G1 exit, decreased shortening increased elongating G1. Furthermore, required timing, as elongates transition. This work reveals are necessary multiple transitions single human cells.

Language: Английский

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Chemical Reactions in Living Systems

Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)

Published: Sept. 7, 2023

Abstract The term “in vivo (“in the living”) chemistry” refers to chemical reactions that take place in a complex living system such as cells, tissue, body liquids, or even an entire organism. In contrast, occur generally outside organisms artificial environment (e.g., test tube) are referred vitro. Over past decades, significant contributions have been made this rapidly growing field of chemistry, but it is still not fully understood, which transformations proceed efficiently without formation by‐products how product environments can be characterized. Potential applications imagined synthesize drug molecules directly within cell confer new cellular functions through controlled will improve understanding systems and develop therapeutic strategies. guiding principles contribution twofold: 1) Which translated from laboratory system? 2) characterization methods suitable for studying structure environments?

Language: Английский

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Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro

Frontiers in Oncology, Journal Year: 2018, Volume and Issue: 8

Published: June 4, 2018

Prostate cancer and osteosarcoma are the second most common type of affecting men fifth malignancy among adolescents, respectively. The use non-toxic natural or natural-derived products has been one current strategies for therapy, owing to reduced risks induced-chemoresistance development absence secondary effects. In this perspective, lactoferrin (Lf), a protein derived from milk, emerges as promising anticancer agent due its well-recognized cytotoxicity anti-metastatic activity. Here, we aimed ascertain potential activity bovine Lf (bLf) against highly metastatic cells. bLf effect on prostate PC-3 MG-63 cell lines, both displaying plasmalemmal V-ATPase, was studied compared with breast MDA-MB-231 non-tumorigenic BJ-5ta lines. Cell proliferation, death, intracellular pH, lysosomal acidification extracellular rate were evaluated. Results show that inhibits induces apoptosis, perturbs only in contrast, cells insensitive bLf. Overall, our results establish mechanism action exhibiting V-ATPase. This study opens perspectives further research role Lf, which ultimately will contribute safer more rational application human therapy these life-threatening cancers.

Language: Английский

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