Phytotherapy Research,
Journal Year:
2020,
Volume and Issue:
34(12), P. 3311 - 3324
Published: July 6, 2020
Abstract
Curcumin,
a
polyphenol
isolated
from
the
rhizome
of
Curcuma
longa
,
has
been
studied
because
its
antioxidant,
antimicrobial,
and
antiinflammatory
properties.
This
study
aimed
to
evaluate
effects
curcumin
on
head
neck
cancer
(HNC)
cell
lines
how
it
modulates
PI3K–AKT–mTOR
signaling
pathway.
Dose‐response
curves
for
were
established
hypopharynx
carcinoma
(FaDu),
tongue
(SCC‐9),
keratinocytes
(HaCaT)
IC
50
values
calculated.
Cell
cycle
death
investigated
through
flow
cytometry.
Cytoskeleton
organization
was
assessed
phalloidin+FITC
staining.
qPCR
array
western
blot
performed
analyze
gene
protein
expression.
Curcumin
reduced
viability
in
dose‐dependent
selective
manner,
induced
SCC‐9
cells
(necrosis/late
apoptosis:
44%
vs.
16.4%
vehicle),
arrested
at
phase
G
2
/M
FaDu
(G
:
SCC‐9—19.1%
13.4%
vehicle;
FaDu—37.8%
12.9%
vehicle).
Disorganized
cytoskeleton
altered
morphology
observed.
Furthermore,
downregulated
pathway
by
modifying
expression
key
genes
proteins.
These
findings
highlight
promising
therapeutic
potential
inhibit
HNC
growth
progression
modulate
Cells,
Journal Year:
2019,
Volume and Issue:
8(12), P. 1584 - 1584
Published: Dec. 6, 2019
Cancer
cells
support
their
growth
and
proliferation
by
reprogramming
metabolism
in
order
to
gain
access
nutrients.
Despite
the
heterogeneity
genetic
mutations
that
lead
tumorigenesis,
a
common
alteration
tumors
occurs
pathways
upregulate
nutrient
acquisition.
A
central
signaling
pathway
controls
metabolic
processes
is
mTOR
pathway.
The
elucidation
of
regulation
functions
can
be
traced
discovery
natural
compound,
rapamycin.
Studies
using
rapamycin
have
unraveled
role
control
cell
metabolism.
By
sensing
intracellular
status,
orchestrates
controlling
uptake
flux
through
various
pathways.
rewiring
makes
it
promising
target
for
cancer
therapy.
Numerous
clinical
trials
are
ongoing
evaluate
efficacy
inhibition
treatment.
Rapamycin
analogs
been
approved
treat
specific
types
cancer.
Since
does
not
fully
inhibit
activity,
new
compounds
engineered
catalytic
activity
more
potently
block
its
functions.
highly
pre-clinical
studies,
early
trial
results
these
second
generation
inhibitors
revealed
increased
toxicity
modest
antitumor
activity.
plasticity
seemingly
enormous
capacity
malignant
salvage
nutrients
mechanisms
make
therapy
extremely
challenging.
Therefore,
identifying
vulnerabilities
different
would
present
opportunities
rational
therapeutic
strategies.
Understanding
how
sources
metabolized
just
growing
tumor
but
also
other
from
microenvironment,
particular,
immune
cells,
will
facilitate
design
sophisticated
effective
regimen.
In
this
review,
we
discuss
illuminated
studies.
We
then
review
key
findings
lessons
learned
both
studies
could
provide
insights
on
innovative
strategies,
including
immunotherapy
network
Molecules,
Journal Year:
2021,
Volume and Issue:
26(13), P. 4100 - 4100
Published: July 5, 2021
Lung
cancer
is
one
of
the
most
common
cancers
and
has
a
high
mortality
rate.
Due
to
its
incidence,
clinical
management
disease
remains
major
challenge.
Several
reports
have
documented
relationship
between
phosphatidylinositol-3-kinase
(PI3K)/
protein
kinase
B
(AKT)/
mammalian
target
rapamycin
(mTOR)
pathway
lung
cancer.
The
recognition
this
as
notable
therapeutic
in
mainly
due
central
involvement
initiation
progression
disease.
Interest
using
natural
synthetic
medications
these
signaling
pathways
increased
recent
years,
with
promising
results
vitro,
vivo,
trials.
In
review,
we
focus
on
current
understanding
PI3K/AKT/mTOR
tumor
development.
addition
pathway,
highlighted
potential
recently
developed
inhibitors
based
preclinical
Drug Resistance Updates,
Journal Year:
2024,
Volume and Issue:
73, P. 101063 - 101063
Published: Feb. 1, 2024
This
study
aims
to
explore
the
function
and
mechanism
of
G
Protein-coupled
receptor
class
C
group
5
member
A
(GPRC5A)
in
docetaxel-resistance
liver
metastasis
breast
cancer.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 703 - 703
Published: Jan. 23, 2023
The
phosphoinositide
3
kinase
(PI3K)-protein
B
(PKB/AKT)-mammalian
target
of
the
rapamycin
(mTOR)
axis
is
a
key
signal
transduction
system
that
links
oncogenes
and
multiple
receptor
classes
which
are
involved
in
many
essential
cellular
functions.
Aberrant
PI3K
signalling
one
most
commonly
mutated
pathways
cancer.
Consequently,
more
than
40
compounds
targeting
components
this
network
have
been
tested
clinical
trials
among
various
types
As
oncogenic
activation
PI3K/AKT/mTOR
pathway
often
occurs
alongside
mutations
other
networks,
combination
therapy
should
be
considered.
In
review,
we
highlight
recent
advances
knowledge
discuss
current
state
future
challenges
practice.
Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Feb. 13, 2023
Colorectal
cancer
(CRC)
is
a
disease
with
complex
pathogenesis,
it
prone
to
metastasis,
and
its
development
involves
abnormalities
in
multiple
signaling
pathways.
Surgery,
chemotherapy,
radiotherapy,
target
therapy,
immunotherapy
remain
the
main
treatments
for
CRC,
but
improvement
overall
survival
rate
quality
of
life
urgently
needed.
Traditional
Chinese
medicine
(TCM)
has
long
history
preventing
treating
CRC.
It
could
affect
CRC
cell
proliferation,
apoptosis,
cycle,
migration,
invasion,
autophagy,
epithelial-mesenchymal
transition,
angiogenesis,
chemoresistance
by
regulating
pathways,
such
as
PI3K/Akt,
NF-κB,
MAPK,
Wnt/β-catenin,
epidermal
growth
factor
receptors,
p53,
TGF-β,
mTOR,
Hedgehog,
immunomodulatory
In
this
paper,
pathways
potential
targets
TCM
active
ingredients
treatment
were
systematically
summarized,
providing
theoretical
basis
new
ideas
further
exploring
pathogenesis
developing
anti-CRC
drugs.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
Breast
cancer
(BC)
is
a
multifaceted
disease
characterized
by
distinct
molecular
subtypes
and
varying
responses
to
treatment.
In
BC,
the
phosphatidylinositol
3-kinase
(PI3K)
pathway
has
emerged
as
crucial
contributor
development,
advancement,
resistance
This
review
article
explores
implications
of
PI3K
in
predictive,
preventive,
personalized
medicine
for
BC.
It
emphasizes
identification
predictive
biomarkers,
such
PIK3CA
mutations,
utility
profiling
guiding
treatment
decisions.
The
also
discusses
potential
targeting
preventive
strategies
customization
therapy
based
on
tumor
stage,
subtypes,
genetic
alterations.
Overcoming
inhibitors
exploring
combination
therapies
are
addressed
important
considerations.
While
this
field
holds
promise
improving
patient
outcomes,
further
research
clinical
trials
needed
validate
these
approaches
translate
them
into
practice.
Graphical
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
After
undergoing
metabolic
reprogramming,
tumor
cells
consume
additional
glutamine
to
produce
amino
acids,
nucleotides,
fatty
and
other
substances
facilitate
their
unlimited
proliferation.
As
such,
the
metabolism
of
is
intricately
linked
survival
progression
cancer
cells.
Consequently,
targeting
presents
a
promising
strategy
inhibit
growth
cell
development.
This
review
describes
uptake,
metabolism,
transport
in
its
pivotal
role
biosynthesis
more.
Furthermore,
we
have
also
summarized
impact
oncogenes
like
C-MYC
,
KRAS
HIF
p53
on
regulation
mechanisms
through
which
triggers
mTORC1
activation.
In
addition,
different
anti-cancer
agents
has
been
described
prospective
applications
are
assessed.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Amino
acid
metabolism
plays
a
pivotal
role
in
tumor
microenvironment,
influencing
various
aspects
of
cancer
progression.
The
metabolic
reprogramming
amino
acids
cells
is
intricately
linked
to
protein
synthesis,
nucleotide
modulation
signaling
pathways,
regulation
cell
metabolism,
maintenance
oxidative
stress
homeostasis,
and
epigenetic
modifications.
Furthermore,
the
dysregulation
also
impacts
microenvironment
immunity.
can
act
as
molecules
that
modulate
immune
function
tolerance
within
reshaping
anti-tumor
response
promoting
evasion
by
cells.
Moreover,
influence
behavior
stromal
cells,
such
cancer-associated
fibroblasts,
regulate
ECM
remodeling
promote
angiogenesis,
thereby
facilitating
growth
metastasis.
Understanding
intricate
interplay
between
crucial
significance.
Expanding
our
knowledge
multifaceted
roles
holds
significant
promise
for
development
more
effective
therapies
aimed
at
disrupting
dependencies
modulating
enhance
responses
inhibit
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 12, 2024
Background:
Everolimus
is
an
inhibitor
of
the
mammalian
target
rapamycin
and
used
to
treat
various
tumors.
The
presented
study
aimed
evaluate
Everolimus-associated
adverse
events
(AEs)
through
data
mining
US
Food
Drug
Administration
Adverse
Event
Reporting
System
(FAERS).
Methods:
AE
records
were
selected
by
searching
FDA
database
from
first
quarter
2009
2022.
Potential
event
signals
mined
using
disproportionality
analysis,
including
reporting
odds
ratio
proportional
Bayesian
confidence
propagation
neural
network
empirical
Bayes
geometric
mean
MedDRA
was
systematically
classify
results.
Results:
A
total
24,575
reports
obtained
FAERS
database,
Everolimus-induced
AEs
occurrence
targeted
24
system
organ
classes
after
conforming
four
algorithms
simultaneously.
common
significant
SOCs
identified,
included
benign,
malignant
unspecified
neoplasms,
reproductive
breast
disorders,
etc.
then
mapped
preferred
terms
such
as
stomatitis,
pneumonitis
impaired
insulin
secretion,
which
have
emerged
in
usually
reported
patients
with
Everolimus.
Of
note,
unexpected
AEs,
biliary
ischaemia,
angiofibroma,
tuberous
sclerosis
complex
uncovered
label.
Conclusion:
This
provided
novel
insights
into
monitoring,
surveillance,
management
drug
reaction
associated
outcome
serious
corresponding
detection
signals,
well
are
worthy
attention
order
improving
clinical
medication
safety
during
treatment
