Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Jan. 9, 2024
Language: Английский
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)
Published: July 23, 2023
Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, dietary changes. Evidence suggests that gut microbiota plays an essential role tumorigenesis CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, microbial carcinogenic mechanisms contribute initiation progression biomarkers potential translational applications screening early diagnosis. microbiota-related interventions could improve anti-tumor therapy's efficacy severe intestinal toxic effects. Chinese researchers made many achievements relationship between CRC, although some challenges remain. This review summarizes current evidence from China on mainly including characteristics, especially Fusobacterium nucleatum Parvimonas micra, which identified be enriched patients; pathogens such as F. enterotoxigenic Bacteroides fragilis, P. scientists extensively studied; diagnostic nucleatum; therapeutic effects, microecological agents represented by certain Lactobacillus strains, fecal transplantation, traditional medicines Berberine Curcumin. More efforts should focused exploring underlying pathogenesis providing novel preventive strategies.
Language: Английский
Citations
53
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 20, 2023
Bazhen Decoction (BZD) is a common adjuvant therapy drug for colorectal cancer (CRC), although its anti-tumor mechanism unknown. This study aims to explore the core components, key targets, and potential mechanisms of BZD treatment CRC.The Traditional Chinese Medicine Systems Pharmacology (TCMSP) was employed acquire BZD's active ingredient targets. Meanwhile, Drugbank, Therapeutic Target Database (TTD), DisGeNET, GeneCards databases were used retrieve pertinent targets CRC. The Venn plot obtain intersection Cytoscape software construct an "herb-ingredient-target" network identify GO KEGG pathway enrichment analyses conducted using R language software. Molecular docking ingredients drugs accomplished PyMol Autodock Vina Cell animal research confirmed efficacy in treating cancer.BZD comprises 173 effective ingredients. Using four databases, 761 related CRC identified. yielded 98 which utilized network. effector components with most quercetin, kaempferol, licochalcone A, naringenin. Protein-protein interaction (PPI) analysis revealed that AKT1, MYC, CASP3, ESR1, EGFR, HIF-1A, VEGFR, JUN, INS, STAT3. findings from molecular suggest exhibits favorable binding target. Furthermore, demonstrates can modulate multiple signaling pathways CRC, like T cell receptor, PI3K-Akt, apoptosis, P53, VEGF pathway. In vitro, studies have shown dose-dependently inhibits colon growth invasion promotes apoptosis. Animal experiments reverse abnormal expression PI3K, AKT, STAT3, TP53 genes. also increases ratio CD4+ cells CD8+ spleen tumor tissues, boosting IFN-γ expression, essential immunity. has downregulate PD-1 on surfaces, indicating ability effectively restore function by inhibiting immune checkpoints. results HE staining safety profiles.BZD treats through metabolic pathways. genes such as TP53, suppresses progression regulating PI3K-AKT, VEGF. increase number promote activation tumor-bearing mice, enhancing against cancer. Among them, naringenin, formaronetin are more highly predictive mice. great significance development novel anti-cancer drugs. It highlights importance pharmacology-based approaches studying complex traditional medicine formulations.
Language: Английский
Citations
26
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Oct. 1, 2024
Language: Английский
Citations
11
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 9, 2024
Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It often diagnosed at middle to advanced stage, affecting approximately 35% of patients the time diagnosis. Currently, chemotherapy has been used improve patient prognosis increase overall survival. However, can also have cytotoxic effects lead adverse reactions, such as inhibiting bone marrow hematopoiesis, causing digestive dysfunction, hand-foot syndrome, even life-threatening conditions. In response these effects, researchers proposed using Traditional Chinese Medicine (TCM) an option treat cancer. TCM research focuses on prescriptions, herbs, components, which form essential components current in medicine. The study implementation prescriptions herbs demonstrate its distinctive holistic approach therapy, characterized by applying multi-component multi-target treatment. TMC advantages developing new drugs they consist single ingredients, require smaller medication dosages, precise measure pharmacodynamic clear mechanism action compared herbs. further still needed determine whether fully substitute therapeutic efficacy prescriptions. This paper presents comprehensive analysis advancements made components. findings this serve theoretical basis for who are interested exploring potential treatment colorectal
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form regulated cell death characterized by iron dependency lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying including intracellular levels, antioxidant system regulation, offer new insights into treatment strategies. This study aims to explore emerging role ferroptosis in context immunotherapy for CRC, highlighting its potential clinical applications. We employed comprehensive review current literature elucidate biological relationship with interplay between immunotherapy. Ferroptosis reshapes tumor microenvironment (TME) regulating metabolism, systems, significantly enhancing efficacy immune checkpoint inhibitors (ICIs). Meanwhile, traditional Chinese medicine therapies promote antitumor immunity modulating TME inducing ferroptosis. Additionally, advances nanotechnology have facilitated precise therapy enabling targeted delivery inducers or immunomodulators, transforming "cold" tumors "hot" further boosting ICI efficacy. comprehensively reviews latest developments immunotherapy, medicine, importance ferroptosis-related biomarkers personalized treatment. In summary, offers promising strategy overcome CRC resistance enhance efficacy, warranting investigation translational application.
Language: Английский
Citations
1
Phytomedicine, Journal Year: 2024, Volume and Issue: 131, P. 155786 - 155786
Published: May 28, 2024
Although AMP-activated protein kinase (AMPK) has been extensively studied in cellular processes, the understanding of its substrates, downstream functions, contributions to cell fate and colorectal cancer (CRC) progression remains incomplete.
Language: Английский
Citations
8
Sustainable Food Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Ginger ( Zingiber officinale L. Z.o.) is a well-known spice that has been used for centuries as food ingredient and in traditional medicine.
Language: Английский
Citations
7
Gastrointestinal Disorders, Journal Year: 2024, Volume and Issue: 6(2), P. 380 - 401
Published: April 13, 2024
Traditional cancer treatments have not significantly improved the survival rates for individuals with colorectal cancer. As a result, there is dire need to explore novel treatment modalities that can target cancer-specific niches, transform cold tumors into hot ones, and disrupt tumor niche. Therapeutic focused ultrasound, recognized its capacity induce thermal mechanical impacts on tissue, potentially eliminate cells elicit body’s anticancer reaction by disrupting microenvironment. This article provides an overview of recent developments in employing therapeutic ultrasound (TFUS) enhance natural defenses against cancers. It also discusses studies examining utility TFUS treating patients research indicating potential stimulate response various vitro vivo models. Furthermore, it explores effects immune system highlights safety effectiveness managing cancer, providing relief from pain, improving rates. Given indications may bolster augment therapy clinical preclinical models, has emerge as pivotal tool settings.
Language: Английский
Citations
6
Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155906 - 155906
Published: July 26, 2024
Language: Английский
Citations
5
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118854 - 118854
Published: Sept. 24, 2024
Language: Английский
Citations
5