Phytotherapy Research,
Journal Year:
2020,
Volume and Issue:
34(12), P. 3311 - 3324
Published: July 6, 2020
Abstract
Curcumin,
a
polyphenol
isolated
from
the
rhizome
of
Curcuma
longa
,
has
been
studied
because
its
antioxidant,
antimicrobial,
and
antiinflammatory
properties.
This
study
aimed
to
evaluate
effects
curcumin
on
head
neck
cancer
(HNC)
cell
lines
how
it
modulates
PI3K–AKT–mTOR
signaling
pathway.
Dose‐response
curves
for
were
established
hypopharynx
carcinoma
(FaDu),
tongue
(SCC‐9),
keratinocytes
(HaCaT)
IC
50
values
calculated.
Cell
cycle
death
investigated
through
flow
cytometry.
Cytoskeleton
organization
was
assessed
phalloidin+FITC
staining.
qPCR
array
western
blot
performed
analyze
gene
protein
expression.
Curcumin
reduced
viability
in
dose‐dependent
selective
manner,
induced
SCC‐9
cells
(necrosis/late
apoptosis:
44%
vs.
16.4%
vehicle),
arrested
at
phase
G
2
/M
FaDu
(G
:
SCC‐9—19.1%
13.4%
vehicle;
FaDu—37.8%
12.9%
vehicle).
Disorganized
cytoskeleton
altered
morphology
observed.
Furthermore,
downregulated
pathway
by
modifying
expression
key
genes
proteins.
These
findings
highlight
promising
therapeutic
potential
inhibit
HNC
growth
progression
modulate
Frontiers in Chemistry,
Journal Year:
2020,
Volume and Issue:
8
Published: Oct. 15, 2020
Pancreatic
cancer
is
the
most
lethal
malignancy
of
gastrointestinal
tract.
Because
its
propensity
for
early
local
and
distant
spread,
affected
patients
possess
extremely
poor
prognosis.
Currently
applied
treatments
are
not
effective
enough
to
eradicate
all
cells,
minimize
their
migration.
Besides,
these
associated
with
adverse
effects
on
normal
cells
organs.
These
therapies
able
increase
overall
survival
rate
patients;
hence,
finding
novel
adjuvants
or
alternatives
so
essential.
Up
now,
medicinal
herbs
were
utilized
therapeutic
goals.
Herbal-based
medicine,
as
traditional
biotherapeutics,
was
employed
treatment.
Of
them,
apigenin,
a
bioactive
flavonoid
that
possesses
numerous
biological
properties
(e.g.,
anti-inflammatory
anti-oxidant
effects),
has
shown
substantial
anticancer
activity.
It
seems
apigenin
capable
suppressing
proliferation
via
induction
cell
cycle
arrest
apoptosis.
inhibits
metastasis
down-regulation
matrix
metalloproteinases
Akt
signaling
pathway.
In
pancreatic
sensitizes
into
chemotherapy,
affects
molecular
pathways
such
hypoxia
inducible
factor
(HIF),
vascular
endothelial
growth
(VEGF),
glucose
transporter-1
(GLUT-1),
etc.
Herein,
biotherapeutic
activity
mechanisms
toward
presented
in
current
review
shed
some
light
anti-tumor
different
cancers,
an
emphasis
cancer.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: June 24, 2021
Lung
adenocarcinoma
(LUAD)
is
the
most
common
subtype
of
non-small
cell
lung
cancer.
Ferroptosis
a
newly
recognized
process
death,
which
different
from
other
forms
death
in
morphology,
biochemistry,
and
genetics,
has
played
vital
role
cancer
biology.
This
study
aimed
to
identify
ferroptosis-related
gene
signature
associated
with
LUAD
prognosis.Dataset
TCGA-LUAD
came
TCGA
portal
was
taken
as
training
cohort.
GSE72094
GSE68465
GEO
database
were
treated
validation
cohorts.
Two
hundred
fifty-nine
genes
retrieved
FerrDb
database.
In
cohort,
Kaplan-Meier
univariate
Cox
analyses
conducted
for
preliminary
screening
potential
prognostic
capacity.
These
then
entered
into
LASSO
regression
model,
constructing
signature.
The
latter
evaluated
cohorts
via
Kaplan-Meier,
Cox,
ROC
analyses.
addition,
correlations
between
risk
score
autophagy
examined
by
Pearson
correlation
coefficient.
GSEA
immune
infiltrating
performed
better
studying
function
annotation
character
each
kind
cells
tumor
microenvironment.A
15-gene
found
cohort
validated
analyses,
revealing
its
independent
prognosis
value
LUAD.
Moreover,
analysis
conducted,
confirming
strong
predictive
ability
that
this
owned
prognosis.
One
fifty-one
222
(68.01%)
autophagy-related
discovered
significantly
correlated
scores.
Analyses
infiltration
exhibited
detail
specific
pathways
associate
identified
crucial
roles
resting
mast
dendritic
signature.In
present
study,
novel
(RELA,
ACSL3,
YWHAE,
EIF2S1,
CISD1,
DDIT4,
RRM2,
PANX1,
TLR4,
ARNTL,
LPIN1,
HERPUD1,
NCOA4,
PEBP1,
GLS2)
built.
It
could
accurately
predict
related
cells,
provide
personalized
outcome
prediction
development
new
therapies
population.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(21), P. 7955 - 7955
Published: Oct. 26, 2020
A
neoplastic
tumor
consists
of
cancer
cells
that
interact
with
each
other
and
non-cancerous
support
the
development
cancer.
One
such
cell
are
tumor-associated
macrophages
(TAMs).
These
secrete
many
chemokines
into
microenvironment,
including
especially
a
large
amount
CCL18.
This
chemokine
is
marker
M2
macrophage
subset;
this
reason
why
an
increase
in
production
CCL18
associated
immunosuppressive
nature
microenvironment
important
element
immune
evasion.
Consequently,
elevated
levels
serum
connected
worse
prognosis
for
patient.
paper
shows
importance
processes.
It
includes
description
signal
transduction
from
PITPNM3
CCL18-dependent
migration,
invasion,
epithelial-to-mesenchymal
transition
(EMT)
cells.
The
angiogenesis
has
also
been
described.
describes
effect
on
recruitment
to
niche
functioning
as
TAMs,
regulatory
T
(Treg),
cancer-associated
fibroblasts
(CAFs)
dendritic
(TADCs).
last
part
possibility
using
therapeutic
target
during
anti-cancer
therapy.
Phytotherapy Research,
Journal Year:
2020,
Volume and Issue:
34(12), P. 3311 - 3324
Published: July 6, 2020
Abstract
Curcumin,
a
polyphenol
isolated
from
the
rhizome
of
Curcuma
longa
,
has
been
studied
because
its
antioxidant,
antimicrobial,
and
antiinflammatory
properties.
This
study
aimed
to
evaluate
effects
curcumin
on
head
neck
cancer
(HNC)
cell
lines
how
it
modulates
PI3K–AKT–mTOR
signaling
pathway.
Dose‐response
curves
for
were
established
hypopharynx
carcinoma
(FaDu),
tongue
(SCC‐9),
keratinocytes
(HaCaT)
IC
50
values
calculated.
Cell
cycle
death
investigated
through
flow
cytometry.
Cytoskeleton
organization
was
assessed
phalloidin+FITC
staining.
qPCR
array
western
blot
performed
analyze
gene
protein
expression.
Curcumin
reduced
viability
in
dose‐dependent
selective
manner,
induced
SCC‐9
cells
(necrosis/late
apoptosis:
44%
vs.
16.4%
vehicle),
arrested
at
phase
G
2
/M
FaDu
(G
:
SCC‐9—19.1%
13.4%
vehicle;
FaDu—37.8%
12.9%
vehicle).
Disorganized
cytoskeleton
altered
morphology
observed.
Furthermore,
downregulated
pathway
by
modifying
expression
key
genes
proteins.
These
findings
highlight
promising
therapeutic
potential
inhibit
HNC
growth
progression
modulate
