Salivaomics to decode non-coding RNAs in oral cancer. A narrative review DOI Creative Commons
Peramaiyan Rajendran, Ramya Sekar, Hamad Abu Zahra

et al.

Non-coding RNA Research, Journal Year: 2023, Volume and Issue: 8(3), P. 376 - 384

Published: May 13, 2023

Oral cancer is the most debilitating disease which affects orderly life of a human. With so much advancement in research and technology, average expectancy an individual with oral appears to be about 5 years. The changing trend incidence among young individuals women without tobacco habits are ascending. Non habit related taking centre stage multiple factors induce complex biology associated such scenarios. To decipher aetiology understand process, these cancerous conditions studied at molecular level. Saliva, non-invasively obtained body fluid assessed for biomarkers exclusively liquid biopsy. This gives huge platform study number molecules cancer. coding RNAs transcripts no protein function. They gaining more importance recent times. Long noncoding RNA, microRNA major types transcriptome that influences progression seem play important role health disease. Apart from these, circulating tumour cells, exosomes, extracellular vesicles, antigens other proteins can saliva. review aimed update knowledge on current saliva their epigenetic as well advances detecting markers identify disease, will help deciding treatment protocol.

Language: Английский

A hierarchically programmable DNA nanodevice for spatiotemporally selective imaging of mitochondrial microRNA in cells and animals DOI
Lie Li, Shuo Xu,

Mingxuan Chen

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 64, P. 102779 - 102779

Published: May 1, 2025

Language: Английский

Citations

0
USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells DOI Creative Commons
Lian Li, Nana Liu,

P Yang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Ubiquitin-specific peptidase 18 (USP18) is a specific interferon-stimulated gene 15 demodifying enzyme that plays an important role in apoptosis. In this study, we investigated the of USP18 apoptosis hepatocellular carcinoma cells, especially its ability to regulate through endoplasmic reticulum (ER) stress. We found protein levels Bcl-2-associated x and cytochrome c were down-regulated by USP18, which suppressed classical mitochondrial-mediated pathway. also inhibited unfolded response (UPR) pathway inhibiting phosphorylation kinase RNA-like (PERK) expression CCAAT/enhance-binding homologous protein, downstream marker molecule ER The UPR triggered stress eventually led cleavage effecter proteases, including caspase-3, leading Furthermore, combined with PERK agonist regulated PERK-eukaryotic initiation factor-2α-activating transcription factor 4 axis UPR. Our results show participates regulation cell different pathways, pathway, it complex responses regulation.

Language: Английский

Citations

0
ER stress and/or ER-phagy in drug resistance? Three coincidences are proof DOI Creative Commons
Sameer Kumar Panda,

Ibone Rubio Sanchez-Pajares,

Ayesha Rehman

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 13, 2025

Language: Английский

Citations

0
MicroRNAs (miRNAs): Novel potential therapeutic targets in colorectal cancer DOI Creative Commons
Yang Ying,

Wenjian Meng,

Ziqiang Wang

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 14, 2022

Colorectal cancer (CRC) is the most common malignant tumor and one of lethal tumors in world. Despite treatment with a combination surgery, radiotherapy, and/or systemic treatment, including chemotherapy targeted therapy, prognosis patients advanced CRC remains poor. Therefore, there an urgent need to explore novel therapeutic strategies targets for CRC. MicroRNAs (miRNAs/miRs) are class short noncoding RNAs (approximately 22 nucleotides) involved posttranscriptional gene expression regulation. The dysregulation its recognized as key regulator related development, progression metastasis In recent years, number miRNAs have been identified regulators drug resistance CRC, some gained attention potential overcome this review, we introduce diverse mechanisms summarize therapies based on miRNAs.

Language: Английский

Citations

16
Salivaomics to decode non-coding RNAs in oral cancer. A narrative review DOI Creative Commons
Peramaiyan Rajendran, Ramya Sekar, Hamad Abu Zahra

et al.

Non-coding RNA Research, Journal Year: 2023, Volume and Issue: 8(3), P. 376 - 384

Published: May 13, 2023

Oral cancer is the most debilitating disease which affects orderly life of a human. With so much advancement in research and technology, average expectancy an individual with oral appears to be about 5 years. The changing trend incidence among young individuals women without tobacco habits are ascending. Non habit related taking centre stage multiple factors induce complex biology associated such scenarios. To decipher aetiology understand process, these cancerous conditions studied at molecular level. Saliva, non-invasively obtained body fluid assessed for biomarkers exclusively liquid biopsy. This gives huge platform study number molecules cancer. coding RNAs transcripts no protein function. They gaining more importance recent times. Long noncoding RNA, microRNA major types transcriptome that influences progression seem play important role health disease. Apart from these, circulating tumour cells, exosomes, extracellular vesicles, antigens other proteins can saliva. review aimed update knowledge on current saliva their epigenetic as well advances detecting markers identify disease, will help deciding treatment protocol.

Language: Английский

Citations

9