Urology reports (St - Petersburg),
Journal Year:
2024,
Volume and Issue:
14(3), P. 315 - 330
Published: Nov. 17, 2024
Urine
analysis
data
obtained
using
modern
microbiological
methods
and
16S
rRNA
gene
sequencing
technology
indicate
that
the
urinary
system
has
its
own
microbial
ecosystem.
Individual
microbiota
members
can
play
a
key
role
in
development
of
cancer.
Certain
bacterial
taxa
have
been
revealed
bladder
urothelial
carcinoma
cells
affect
carcinogenesis,
treatment
response,
relapses
through
various
mechanisms.
The
studies
are
conducted
to
use
not
only
vaccine
strains,
but
also
probiotic
strains
oncolytic
bacteria
for
prevention
relapses.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
BMC Cancer,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: April 4, 2024
Abstract
Background
Through
research
on
the
gut
microbiota
(GM),
increasing
evidence
has
indicated
that
GM
is
associated
with
esophageal
cancer
(ESCA).
However,
specific
cause-and-effect
relationship
remains
unclear.
In
this
study,
Mendelian
randomization
(MR)
analysis
was
applied
to
investigate
causal
between
and
ESCA,
including
its
subtypes.
Methods
We
collected
information
211
GMs
acquired
data
ESCA
subtypes
through
genome-wide
association
studies
(GWASs).
The
primarily
assessed
using
inverse
variance
weighted
(IVW)
method.
Additionally,
we
median
estimator
(WME)
method,
MR–Egger
mode,
simple
mode
provide
further
assistance.
Subsequent
these
analyses,
sensitivity
conducted
intercept
test,
MR-PRESSO
global
leave-one-out
Result
Following
our
assessment
five
methods
analysis,
identified
seven
potential
relationships
At
genus
level,
Veillonella
Coprobacter
were
positively
correlated
whereas
Prevotella9
,
Eubacterium
oxidoreducens
group
Turicibacter
negatively
ESCA.
case
of
adenocarcinoma
(EAC),
Flavonifractor
exhibited
a
positive
correlation,
while
Actinomyces
negative
correlation.
Conclusion
Our
study
revealed
subtypes,
offering
novel
insights
for
advancement
diagnosis
treatment.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 809 - 809
Published: Jan. 28, 2023
Background:
Increasing
evidence
points
to
the
urinary
microbiota
as
a
possible
key
susceptibility
factor
for
early-stage
bladder
cancer
(BCa)
progression.
However,
interpretation
of
its
underlying
mechanism
is
often
insufficient,
given
that
various
environmental
conditions
have
affected
composition
microbiota.
Herein,
we
sought
rule
out
confounding
factors
and
clarify
how
Eubacterium
sp.
CAG:581
promoted
non-muscle
invasive
(NMIBC)
development.
Methods:
Differentially
abundant
51
NMIBC
patients
47
healthy
controls
(as
Cohort
1)
were
first
determined
by
metagenomics
analysis.
Then,
modeled
coculture
organoids
with
candidate
in
anaerobic
explored
differentially
expressed
genes
these
tissues
RNA-Seq.
Furthermore,
dissected
mechanisms
involved
into
inducing
extracellular
matrix
protein
1
(ECM1)
metalloproteinase
9
(MMP9)
upregulation.
Finally,
used
multivariate
Cox
modeling
investigate
clinical
relevance
16S
ribosomal
RNA
(16SrRNA)
levels
prognosis
406
2).
Results:
infection
accelerated
proliferation
(p
<
0.01);
ECM1
MMP9
most
upregulated
induced
increased
colony
forming
units
(CFU)
gradient
via
phosphorylating
ERK1/2
1.
Excluding
favorable
impact
potential
contributing
factors,
ROC
curve
2
manifested
3-year
AUC
value
0.79
cut-off
point
16SrRNA
10.3
(delta
CT
value).
Conclusion:
Our
suggests
progression
through
ECM1/MMP9
pathway,
which
may
serve
promising
noninvasive
diagnostic
biomarker
NMIBC.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: May 23, 2023
Microorganisms
have
been
identified
in
tumor
specimens
for
over
a
century.
It
is
only
recent
years
that
tumor-associated
microbiota
has
become
rapidly
expanding
field.
Assessment
techniques
encompass
methods
at
the
frontiers
of
molecular
biology,
microbiology,
and
histology,
requiring
transdisciplinary
process
to
carefully
decipher
this
new
component
microenvironment.
Due
low
biomass,
study
poses
technical,
analytical,
biological,
clinical
challenges
must
be
approached
as
whole.
To
date,
several
studies
begun
shed
light
on
composition,
functions,
relevance
microbiota.
This
piece
microenvironment
puzzle
could
potentially
change
way
we
think
about
treat
patients
with
cancer.
Clinical Microbiology Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
SUMMARYBacillus
Calmette-Guérin
(BCG)
has
been
the
standard
treatment
for
non-muscle-invasive
bladder
cancer
over
30
years.
Despite
its
proven
efficacy,
challenges
persist,
including
unclear
mechanisms
of
action,
resistance
in
30%-50%
patients,
and
significant
side
effects.
This
review
presents
an
updated
balanced
discussion
antitumor
BCG,
focusing
on
direct
effects
interactions
with
various
cell
types
within
tumor
microenvironment.
Notably,
recent
research
between
BCG
microbiome
is
also
incorporated.
We
further
summarize
analyze
latest
preclinical
clinical
studies
regarding
both
intrinsic
adaptive
to
cancer.
Based
current
understanding
BCG's
therapeutic
principles
mechanisms,
we
systematically
explore
strategies
improve
BCG-based
immunotherapy.
These
include
development
recombinant
combination
therapy
different
drugs,
optimization
regimens
management,
exploration
new
approaches
by
targeting
changes
microbiota
metabolites.
measures
aim
effectively
address
cancer,
reduce
toxicity,
ultimately
enhance
anti-tumor
efficacy.
Bacterial
therapy,
represented
genetically
engineered
oncolytic
bacteria,
gradually
emerged
field
As
only
bacterial
drug
successfully
approved
oncology
use,
provided
decades
experience.
By
consolidating
lessons
from
successes
limitations,
hope
provide
valuable
insights
application
therapies
treatment.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 14, 2025
Microbiomes
have
been
linked
to
oncogenesis,
e.g.
the
intestinal
microbiome
and
colon
cancer
or
HPV-associated
cervical
cancer.
A
connection
between
microbiomes
of
different
body
cavities
tumor
oncogenesis
was
shown.
The
gut
microbiome's
influence
on
bladder
established,
raising
question
whether
nearby
(rectum,
vagina)
also
due
their
proximity.
Considering
various
broader
microbial
components,
this
systematic
review
aims
investigate
differences
in
bladder,
vaginal,
microbiota-including
bacterial,
viral,
fungal
archaea-between
patients
with
healthy
controls.
Databases
(PubMed,
Scopus,
Embase)
were
searched
until
April
2022.
Three
types
studies
included:
"(1)
using
control
groups
(case-controlled
studies)
(2)
that
provided
information
presence
abundance
taxa
(3)
increased
decreased
and/or
groups.".
Risk
bias
assessed
Newcastle
Ottawa
Scale.
Fourteen
(695
samples:
403
cancer,
292
controls)
analyzed.
Bacterial
detected
at
least
two
studies,
genera
Geobacillus
Rubrobacter
more
frequently
patients;
while
Streptococcus
Roseomonas
prevalent
No
consistent
identified
across
stool
tissue
samples.
microbiota
show
significant
variation
studies.
Standardized
methods
expanded
investigations
into
viral
components
are
needed
clarify
role
