Experimental Cell Research, Journal Year: 2023, Volume and Issue: 428(2), P. 113621 - 113621
Published: May 1, 2023
Language: Английский
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)
Published: Sept. 4, 2023
Abstract The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), cellular components include cancer non-malignant such as immune stromal cells. These three types establish complex signals in the body further influence genesis, development, metastasis participate resistance to anti-tumor therapy. It has attracted scholars study TME due significant efficacy checkpoint inhibitors (ICI) chimeric antigen receptor T (CAR-T) solid tumors hematologic tumors. After more than 10 years efforts, role strategy treating based on have developed rapidly. Moreover, ICI been recommended by guidelines first- or second-line treatment strategies a variety At same time, another major class TME, which also play very important metabolism, growth, metastasis, evasion resistance. Stromal can be recruited from neighboring non-cancerous host formed transdifferentiation they development drug secreting various factors exosomes, participating angiogenesis regulating response matrix. However, with deepening understanding cells, people found that not only effect promoting but inhibit some cases. In this review, we will introduce origin well specific mechanism tumorigenesis for We focus tumor-associated fibroblasts (CAFs), mesenchymal stem (MSCs), adipocytes (CAAs), endothelial (TECs) pericytes (PCs)
Language: Английский
Citations
154
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114491 - 114491
Published: March 13, 2023
Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stromal a paracrine manner, the factor (PDGF)/platelet-derived receptor (PDGFR) pathway is crucial spread of several cancers. To combat hypoxia microenvironment, it encourages angiogenesis. A growing body experimental data shows that PDGFs target malignant cells, vascular to modulate growth, metastasis, microenvironment. medication resistance enhance patient outcomes cancers, targeting PDGF/PDGFR viable therapeutic approach. There have been reports anomalies pathway, including gain function point mutations, activating chromosomal translocations, overexpression amplification As result, has shown signaling effective method for treating cancer. this study will concentrate on regulation system, particular current methods inhibitors used cancer treatment, as well associated advantages side effects.
Language: Английский
Citations
71
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)
Published: May 16, 2024
Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.
Language: Английский
Citations
9
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 19, 2025
Abstract Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) capable penetrating deeply into tumor tissues utilizing photodynamic-triggered explosive energy and receptor-mediated transcytosis, significantly enhancing therapeutic efficacy breast cancer. The were fabricated by loading powerful components chlorin e6 MnO 2 nanoparticles, as well Doxorubicin, crosslinked Ca 2+ -gel. Upon exposure laser irradiation, obtained are generating energy, resulting fragmentation numerous nanofragments. subsequently drives these nanofragments penetrate through gap leakage among cells. In addition, also promotes escape those (including e6, doxorubicin) from lysosomes. subsequent stages, exhibit excellent transcytosis capacity, facilitating deep tissues. As expected, enhanced accumulation can be achieved, anti-proliferation capacity against
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782
Published: April 19, 2025
Language: Английский
Citations
1
Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 1 - 13
Published: Aug. 23, 2022
Language: Английский
Citations
36
Advanced Science, Journal Year: 2022, Volume and Issue: 9(30)
Published: Aug. 31, 2022
Abstract A malformed tumour vascular network provokes the nutrient‐deprived microenvironment (TME), which conversely activates endothelial cell (EC) functions and stimulates neovascularization. Emerging evidence suggests that flexible metabolic adaptability of cells helps to establish a symbiosis among various subpopulations in fluctuating TME. In this study, authors propose novel link between bladder cancer (BCa) ECs nutrient‐scarce TME, BCa‐secreted glutamine‐fructose‐6‐phosphate aminotransferase 1 (GFAT1) via small extracellular vesicles (sEVs) reprograms glucose metabolism by increasing hexosamine biosynthesis pathway flux thus enhances O‐GlcNAcylation. Moreover, seryl‐tRNA synthetase (SerRS) O‐GlcNAcylation at serine 101 promotes its degradation ubiquitination impeded importin α 5‐mediated nuclear translocation. Intranuclear SerRS attenuates growth factor transcription competitively binding GC‐rich region proximal promotor. Additionally, GFAT1 knockout blocks angiogenesis both vitro vivo. However, administration GFAT1‐overexpressing BCa cells‐derived sEVs increase angiogenetic activity GFAT1‐knockout mice. summary, study inhibiting sEV‐mediated secretion from targeting may serve as strategies for antiangiogenetic therapy.
Language: Английский
Citations
32
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Lung cancer is the second most commonly diagnosed and a leading cause of cancer-related death, with non-small cell lung (NSCLC) being prevalent type. Over 70% patients require radiotherapy (RT), which operates through direct indirect mechanisms to treat cancer. However, RT can damage healthy tissues encounter radiological resistance, making it crucial enhance its precision optimize treatment outcomes, minimize side effects, overcome radioresistance. Integrating nanotechnology into presents promising method increase efficacy. This review explores various nano-assisted strategies aimed at achieving treatment. These include using nanomaterials as radiosensitizers, applying modify tumor microenvironment, employing nano-based radioprotectors radiation-treated products for RT. We also explore recent advancements in NSCLC, such biomimetic targeting that alters mesenchymal stromal cells, magnetic strategies, nanosensitization high-atomic number nanomaterials. Finally, we address existing challenges future directions nanotechnology, highlighting potential clinical applications.
Language: Английский
Citations
7
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114806 - 114806
Published: May 8, 2023
In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing vessels, considered one important processes in tumor growth and metastasis. a complex process regulated various factors involves many secreted signaling pathways. transport oxygen nutrients during development. Therefore, inhibition angiogenesis has become an strategy clinical management solid tumors. Combination therapies inhibitors with radiotherapy chemotherapy are often used practice. this article, we will review common targets against angiogenesis, most up-to-date anti-angiogenic drugs treatments recent years, including active ingredients chemical herbal medicines.
Language: Английский
Citations
16
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 24, 2024
Osteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis usually present upon initial diagnosis, and the primary factor affecting poor prognosis of patients with OS. Current research shows that ability to regulate cellular microenvironment essential for preventing distant OS, anoxic microenvironments are important features solid tumors. During hypoxia, hypoxia-inducible factor-1α (HIF-1α) expression levels stability increase. Increased HIF-1α promotes vascular remodeling, epithelial-mesenchymal transformation (EMT), OS cells invasiveness; this leads cells. plays an role in mechanisms metastasis. In order develop precise prognostic indicators potential therapeutic targets treatment, review examines molecular cells; signal transduction pathways mediated by also discussed.
Language: Английский
Citations
5