A literature review on the potential clinical implications of streptococci in gastric cancer DOI Creative Commons
Mengli Zi, Yanqiang Zhang, Can Hu

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 26, 2022

Streptococcus is widely found in nature and the human body, most species are not pathogenic. In recent years, studies have that associated with gastric cancer. was to be enriched oral cavity, stomach intestine of cancer patients increased tissues, suggesting may pathogenic bacteria underlying This review discusses discovery Streptococcus, relationship between cancer, possible carcinogenic mechanism summarizes progress research on role provide new ideas for early detection, diagnosis treatment

Language: Английский

Updates on global epidemiology, risk and prognostic factors of gastric cancer DOI Creative Commons
Wenjuan Yang, Heping Zhao, Yan Yu

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(16), P. 2452 - 2468

Published: April 24, 2023

Gastric cancer (GC) is defined as the primary epithelial malignancy derived from stomach, and it a complicated heterogeneous disease with multiple risk factors. Despite its overall declining trend of incidence mortality in various countries over past few decades, GC remains fifth most common fourth leading cause cancer-related death globally. Although global burden has shown significant downward trend, severe certain areas, such Asia. ranks third among all types China, accounts for nearly 44.0% 48.6% new cases GC-related deaths world, respectively. The regional differences are obvious, annual increasing rapidly some developing regions. Therefore, early preventive screening strategies urgently needed. clinical efficacies conventional treatments limited, understanding pathogenesis increased demand therapeutic regimens, including immune checkpoint inhibitors, cell immunotherapy vaccines. present review describes epidemiology worldwide, especially summarizes prognostic factors, focuses on novel immunotherapies to develop management patients.

Language: Английский

Citations

187
RE.GA.IN.: the Real-world Gastritis Initiative–updating the updates DOI Creative Commons
Massimo Rugge, Robert M. Genta, Peter Malfertheiner

et al.

Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 331164

Published: Feb. 21, 2024

At the end of last century, a far-sighted ‘working party’ held in Sydney, Australia addressed clinicopathological issues related to gastric inflammatory diseases. A few years later, an international conference Houston, Texas, USA critically updated seminal Sydney classification. In line with these initiatives, Kyoto Global Consensus Report, flanked by Maastricht-Florence conferences, added new clinical evidence gastritis puzzle. The most relevant topics diseases have been Real-world Gastritis Initiative (RE.GA.IN.), from disease definitions diagnosis and prognosis. This paper reports conclusions RE.GA.IN. consensus process, which culminated Venice November 2022 after more than 8 months intense global scientific deliberations. forum scholars five continents participated multidisciplinary consensus. After lively debates on controversial aspects spectrum, Faculty amalgamated complementary knowledge distil patient-centred, evidence-based statements assist health professionals their real-world practice. sections this report focus on: epidemiology gastritis; Helicobacter pylori as dominant aetiology environmental important determinant oncogenetic field; evolving autoimmunity; relevance microbiota; diagnostic horizons endoscopy; priority histologically reporting terms staging. ultimate goal was remains promotion further improvement management patients gastritis.

Language: Английский

Citations

43
The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes DOI Creative Commons
Mengying Xia, Lei Lei, Lin-Yong Zhao

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 2, 2025

Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.

Language: Английский

Citations

3
Asiaticoside promoted ferroptosis and suppressed immune escape in gastric cancer cells by downregulating the Wnt/β-catenin pathway DOI

Chenmin Ye,

Zhichao Yao, Yaoyao Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 134, P. 112175 - 112175

Published: May 11, 2024

Language: Английский

Citations

13
Investigating the role of inflammatory cytokines in mediating the effect of gut microbiota on gastrointestinal cancers: a mendelian randomization study DOI
Wentao Liu, Xinwen Hu,

Y.M. Choy

et al.

Gastric Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

1
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier DOI Creative Commons
Jianhui Liu, Yi Dai,

Wenjian Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Edible and medicinal mushroom polysaccharides (EMMPs) have been widely studied for their various biological activities. It has shown that EMMPs could modulate microbiota in the large intestine improve intestinal health. However, role of protecting gastric barrier, regulating microbiota, improving health cannot be ignored. Hence, this review will elucidate effect on barriers, with emphasis interaction maintaining overall gastrointestinal Additionally, highlights gastroprotective effects underlying mechanisms against mucosa injury, gastritis, ulcer, cancer. Furthermore, diseases, including inflammatory bowel disease, colorectal cancer, infection, are also summarized. This discuss future perspective challenges use as a dietary supplement or nutraceutical preventing treating diseases.

Language: Английский

Citations

1
Helicobacter pylori-associated Chronic Atrophic Gastritis and Progression of Gastric Carcinogenesis DOI Creative Commons
Na Rae Lim, Woo Chul Chung

Korean Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 82(4), P. 171 - 179

Published: Oct. 25, 2023

Other SectionsAbstractINTRODUCTIONMAIN SUBJECTCONCLUSIONFinancial supportConflict of interestReferences

Language: Английский

Citations

18
Immunotherapy of gastric cancer: Present status and future perspectives DOI Creative Commons
John K. Triantafillidis,

Manousos M. Konstadoulakis,

Αpostolos Papalois

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(8), P. 779 - 793

Published: Feb. 26, 2024

In this editorial, we comment on the article entitled "Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric clinical trial review (1999-2023)," which was published recent issue of

Language: Английский

Citations

7
The role of microbiota in the development and treatment of gastric cancer DOI Creative Commons
Yiwen Wang, Wenjie Han, Na Wang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 29, 2023

The stomach was once considered a sterile organ until the discovery of Helicobacter pylori (HP) . With application high-throughput sequencing technology and macrogenomics, researchers have identified fungi fivemajor bacterial phyla within stomachs healthy individuals. These microbial communities exert regulatory influence over various physiological functions, including energy metabolism immune responses. HP is well-recognized risk factor for gastric cancer, significantly altering stomach’s native microecology. Currently, numerous studies are centered on mechanisms by which contributes to cancer development, primarily involving CagA oncoprotein. However, aside from exogenous infections such as EBV, certain endogenous dysbiosis can also lead through multiple mechanisms. Additionally, gut microbiota its metabolites impact development cancer. role therapies, diet, phages, probiotics fecal transplantation, in treating should not be underestimated. This review aims study involved roles pathogen infection Also, we describe therapy treatment prognosis

Language: Английский

Citations

15
Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment DOI Creative Commons

Yue Qiu,

Guimei Lu,

Na Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of gastric mucosa. The pathogenesis GC intricately linked to tumor microenvironment within which reside. Tumor-associated macrophages (TAMs) primarily differentiate peripheral blood monocytes and can be broadly categorized into M1 M2 subtypes. M2-type TAMs have been shown promote growth, tissue remodeling, angiogenesis. Furthermore, they actively suppress acquired immunity, leading poorer prognosis reduced tolerance chemotherapy. Exosomes, contain myriad biologically active molecules including lipids, proteins, mRNA, noncoding RNAs, emerged as key mediators communication between TAMs. exchange these via exosomes markedly influence consequently impact progression. Recent studies elucidated correlation various clinicopathological parameters GC, such size, differentiation, infiltration depth, lymph node metastasis, TNM staging, highlighting pivotal role in development metastasis. In this review, we aim comprehensively examine bidirectional TAMs, implications alterations on immune escape, invasion, metastasis targeted therapeutic approaches for efficacy potential drug resistance strategies.

Language: Английский

Citations

6