Diet induced thermogenesis, older and newer data with emphasis on obesity and diabetes mellitus - A narrative review DOI Creative Commons
Evangelia Tzeravini, Anastasios Tentolouris, Alexander Kokkinos

et al.

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100291 - 100291

Published: June 1, 2024

Obesity is a major public health problem with prevalence increasing at an alarming rate worldwide. There urgent need for efficient approaches to weight management. Diet induced thermogenesis (DIT) the process by which body increases its energy expenditure in response meal. It estimated account approximately 10% of total and considered potentially modifiable component expenditure. The palatability food, meal's composition macronutrients, circadian rhythm sleep, as well individual's characteristics such age sex, presence obesity or diabetes mellitus, proportion physical activity are main factors that affect DIT. However, studies examining DIT mostly characterized small sample size methodology varies considerably between studies. seems even today there lot contradiction relative Inspite that, future research might lead modification order achieve some loss obese people.

Language: Английский

Multiple myeloma DOI

Florent Malard,

Paola Neri, Nizar J. Bahlis

et al.

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 27, 2024

Language: Английский

Citations

53
The Burden of Multiple Myeloma in China: Trends from 1990 to 2021 and Forecasts for 2050 DOI Creative Commons
Xuelin Dou, Guangcai Duan,

You Zhong

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217440 - 217440

Published: Jan. 2, 2025

Language: Английский

Citations

2
Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity DOI
Hanghang Liu, Linyi Liu,

Clifford J. Rosen

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 14, 2025

Language: Английский

Citations

0
Global Epidemiology, Burden, and Risk Factor of Multiple Myeloma: Past, Present, and Future DOI
Peilin Zhou, Xiang Chen,

Wenqiang Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Causal relationships between body composition and hematological malignancies: a multivariable mendelian randomization analysis DOI
Shan Liu, Yaobin Lin, Zhihong Wang

et al.

Cancer Causes & Control, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Obesity: pathophysiology and therapeutic interventions DOI Creative Commons
Yue Kong, Hong Seuk Yang, Rong Nie

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 25, 2025

Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.

Language: Английский

Citations

0
Global, regional, and national burden of multiple myeloma from 1990 to 2021 and projections for 2040: a systematic analysis for the global burden of disease 2021 study DOI Creative Commons

Yuying Wei,

Wenjuan Gao, Shuai Wang

et al.

Frontiers in Epidemiology, Journal Year: 2025, Volume and Issue: 5

Published: April 29, 2025

Multiple myeloma (MM) is a malignant hematologic disorder characterized by the abnormal clonal proliferation of bone marrow plasma cells and excessive production immunoglobulins, often leading to severe organ damage. Due its high incidence, recurrence, death rates, MM poses significant burden on individuals global healthcare systems. This study leverages latest data from Global Burden Disease Study 2021 (GBD 2021) analyze epidemiological trends propose effective preventive strategies. Using GBD 2021, we analyzed age-standardized incidence rate (ASIR), (ASDR), disability-adjusted life years (DALYs) MM, evaluating temporal through estimated annual percentage change (EAPC). Pearson correlation analysis was employed explore relationship between rates (ASRs) Sociodemographic Index (SDI). Additionally, frontier conducted. Finally, Bayesian age-period-cohort models were utilized predict ASRs 2040. In number new cases 148,755 (95% UI: 131,780.4-162,049.2), with 116,359.6 deaths 103,078.6-128,470.6) 2,595,595 DALYs 2,270,483.6-2,889,968.2). Age-standardized increased age. Between 1990 exhibited consistent upward trend across all populations, males older adults bearing highest burden. The demonstrated positive SDI. Frontier indicated regions medium-to-high SDI have greatest potential for reducing ASRs. Among risk factors, body mass index (BMI) identified as most contributor MM. Projections suggest that 2040, may experience decline. Driven population aging advancements in diagnostic capabilities, multiple continues rise. Targeted prevention treatment strategies, particularly elderly high-risk are essential alleviate disease improve patient outcomes.

Language: Английский

Citations

0
Mechanisms underlying obesity-malignancy connection: a systematic narrative review DOI
Ayesha Sultana, Sobia Rana

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Language: Английский

Citations

0
Correlation Between Bariatric Surgery and the Risk of Multiple Myeloma: Results from an Evidence-Based Strategy DOI
Qiong Wu, Tiantian Zhao, Chenglou Zhu

et al.

Obesity Surgery, Journal Year: 2024, Volume and Issue: 34(4), P. 1061 - 1072

Published: Jan. 17, 2024

Language: Английский

Citations

3
Soluble mannose receptor: A potential biomarker in Gaucher disease DOI Creative Commons
Brendan Beaton, Derralynn Hughes

European Journal Of Haematology, Journal Year: 2024, Volume and Issue: 112(5), P. 794 - 801

Published: Jan. 10, 2024

Abstract Purpose Soluble mannose receptor (sMR) relates to expression on macrophages, and is elevated in inflammatory disorders. Gaucher disease (GD) has altered macrophage function utilises receptors for enzyme replacement therapy (ERT) endocytosis. sMR not previously been studied GD. Methods was measured by ELISA correlated with GD clinical features including spleen liver volume, haemoglobin platelet count, bone marrow burden (BMB) scores immunoglobulin levels. compared biomarkers of GD: chitotriosidase, lyso‐GL1, PARC, CCL3, CCL4, osteoactivin, serum ACE ferritin. Results Median untreated patients 303.0 ng/mL post‐treatment 190.9 ( p = .02) healthy controls 202 ng/mL. median volume 455 mL r .70, .04), 2025 .64, BMB 7 .8, .03), IgA 1.9 g/L .54, .036), IgG 9.2 .57, .027), IgM 1.45 .86, < .0001), inverse correlation count 125 × 10 9 /L −.47, .08) 137 −.77, .0008). established biomarkers: osteoactivin 107.8 .58, .0006), chitotriosidase 3042 nmol/mL/h .52, PARC 800 .67, .0068), ferritin 547 μg/L .72, .002) CCL3 50 pg/mL .007). Conclusions correlates reduces following therapy.

Language: Английский

Citations

2