Identification of Vesicle‐Mediated Transport‐Related Genes for Predicting Prognosis, Immunotherapy Response, and Drug Screening in Cervical Cancer DOI Creative Commons
Shuai Lou, Hongqing Lv,

Lin Zhang

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(11)

Published: Nov. 1, 2024

ABSTRACT Background Cervical cancer is one of the most common malignancies among women. Vesicle‐mediated transport mechanisms significantly influence tumor cell behavior through intercellular material exchange. However, prognostic significance in CC patients remains underexplored. Research Design and Methods We identified differentially expressed vesicle‐mediated transport‐related genes from TCGA GeneCards datasets differential expression analysis. constructed a model using Cox regression LASSO regression, categorized into high‐ low‐risk groups, validated GEO data set. A nomogram integrating clinical features risk scores demonstrated model's independent capability. analyzed immune infiltration, checkpoints, predicted immunotherapy responses groups. Finally, we screened potential drugs for targeting conducted drug‐sensitivity Results successfully established 10‐gene based on VMTRGs. The group exhibited favorable prognosis, significant promising response, whereas high‐risk showed higher sensitivity to chemotherapeutic agents such as Docetaxel Paclitaxel. Potential included Megestrol acetate, Lenvatinib, Adavosertib, Barasertib. Conclusions VMTRG‐based demonstrates reliable value enhances understanding CC.

Language: Английский

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells DOI Creative Commons
Wenkai Chen,

Zongguang Li,

Naichun Yu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 30, 2023

In recent years, the development of BMSCs-derived exosomes (EXO) for treatment osteosarcoma (OS) is a safe and promising modality OS treatment, which can effectively deliver drugs to tumor cells in vivo. However, differences carried, binding EXOs other organs limit their therapeutic efficacy. Therefore, improving OS-targeting ability BMSCs developing new crucial clinical application targeted therapy OS.In this study, we constructed potential nano platform by modifying using bone-targeting peptide SDSSD encapsulated capreomycin (CAP) within shell. These nanoparticles (NPs) showed homologous targeting (BT-EXO) significantly promotes cellular endocytosis vitro accumulation Furthermore, our results revealed that NPs induced ferroptosis prompting excessive reactive oxygen species (ROS), Fe2+ aggregation, lipid peroxidation further identified anticancer molecular mechanism as transduced Keap1/Nrf2/GPX4 signaling pathway. Also, these NP-directed significant inhibition growth vivo with no side effects.These suggest have superior activity mouse models vivo, providing strategy combining ferroptosis-based chemotherapy OS.

Language: Английский

Citations

26
Unraveling the Connection Between Ion Channels and Pancreatic Stellate Cell Activation DOI Creative Commons
Julie Auwercx,

Mathilde Fourgeaud,

Alexis Lalot

et al.

Cellular Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 59(S1), P. 25 - 40

Published: Jan. 18, 2025

Quiescent pancreatic stellate cells (PSCs) represent only a very low proportion of the tissue, but their activation leads to stroma remodeling and fibrosis associated with pathologies such as chronic pancreatitis ductal adenocarcinoma (PDAC). PSC can be induced by various stresses, including acidosis, growth factors (PDGF, TGFβ), hypoxia, high pressure, or intercellular communication cancer cells. Activated targeting represents promising therapeutic strategy, little is known regarding molecular mechanisms underlying PSCs. Identification new biomarkers desmoplasia in PDAC could lead targets for exocrine disease treatments. Ion channels transporters are transmembrane proteins involved numerous physiological pathological processes, PDAC. They well act biosensors tissue microenvironment, they easily accessible drugs. However, role not fully understood. In this review, we briefly discuss activated PSCs pancreas inflammation (associated PDAC), describe specific ion (Ca2+, K+, Na+ Cl-) these processes light recent literature.

Language: Английский

Citations

1
Exosome subpopulations: The isolation and the functions in diseases DOI

Xinyi Ma,

Zhenhua Chen, Wei Chen

et al.

Gene, Journal Year: 2023, Volume and Issue: 893, P. 147905 - 147905

Published: Oct. 14, 2023

Language: Английский

Citations

14
Breaking the stromal barrier in pancreatic cancer: Advances and challenges DOI

Mohana Chakkera,

Jeremy B. Foote, Batoul Farran

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189065 - 189065

Published: Dec. 30, 2023

Language: Английский

Citations

14
Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment DOI Creative Commons

Yue Qiu,

Guimei Lu,

Na Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of gastric mucosa. The pathogenesis GC intricately linked to tumor microenvironment within which reside. Tumor-associated macrophages (TAMs) primarily differentiate peripheral blood monocytes and can be broadly categorized into M1 M2 subtypes. M2-type TAMs have been shown promote growth, tissue remodeling, angiogenesis. Furthermore, they actively suppress acquired immunity, leading poorer prognosis reduced tolerance chemotherapy. Exosomes, contain myriad biologically active molecules including lipids, proteins, mRNA, noncoding RNAs, emerged as key mediators communication between TAMs. exchange these via exosomes markedly influence consequently impact progression. Recent studies elucidated correlation various clinicopathological parameters GC, such size, differentiation, infiltration depth, lymph node metastasis, TNM staging, highlighting pivotal role in development metastasis. In this review, we aim comprehensively examine bidirectional TAMs, implications alterations on immune escape, invasion, metastasis targeted therapeutic approaches for efficacy potential drug resistance strategies.

Language: Английский

Citations

6
The Role of Extracellular Vesicles in Metabolic Diseases DOI Creative Commons
Carlos González-Blanco,

Sarai Iglesias-Fortes,

Ángela Cristina Lockwood

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 992 - 992

Published: April 30, 2024

Extracellular vesicles represent a group of structures with the capacity to communicate different cells and organs. This complex network interactions can regulate multiple physiological processes in organism. Very importantly, these be altered during appearance diseases including cancer, metabolic diseases, etc. In addition, extracellular transport cargoes, altering initiation disease, driving progression, or even accelerating pathogenesis. Then, we have explored implication alterations such as pancreatic diabetes its complications non-alcoholic fatty liver disease. Finally, more detail communication between pancreas. summary, very efficient system for among tissues permit an biomarkers well being involved extracellular-vesicle-mediated molecules, serving potential therapy diseases.

Language: Английский

Citations

5
Exploring Extracellular Vesicles: A Novel Approach in Nonalcoholic Fatty Liver Disease DOI

Ana Isabel Vigil Medina,

Mengdie Shi,

Yanyan Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Nonalcoholic fatty liver disease (NAFLD) represents an increasing public health concern. The underlying pathophysiological mechanisms of NAFLD remains unclear, and as a result, there is currently no specific therapy for this condition. However, recent studies focus on extracellular vesicles (EVs) novelty in their role cellular communication. An imbalance the gut microbiota composition may contribute to progression NAFLD, making gut-liver axis promising target therapeutic strategies. This review aims provide comprehensive overview EVs NAFLD. Additionally, exosome-like nanovesicles derived from plants (PELNs) probiotics-derived (postbiotics) have demonstrated potential re-establish intestinal equilibrium modulate microbiota, thus offering alleviate via axis. Further research needed using multiple omics approaches comprehensively characterize cargo including protein, metabolites, genetic material packaged, biological activities diverse microbes plants.

Language: Английский

Citations

0
The function of microRNA related to cancer-associated fibroblasts in pancreatic ductal adenocarcinoma DOI

Yaohui Fang,

Chunlu Tan,

Zhenjiang Zheng

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 236, P. 116849 - 116849

Published: March 6, 2025

Language: Английский

Citations

0
Scaffold-free endocrine tissue engineering: role of islet organization and implications in type 1 diabetes DOI Creative Commons
Tuğba Bal

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 21, 2025

Language: Английский

Citations

0
IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer DOI Creative Commons
Di Wu,

Zhiliang Wang,

Yue Zhang

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with poor prognosis, and the lack of effective treatment methods accounts for its high mortality. Pancreatic stellate cells (PSCs) in tumor microenvironment play an important role development PDAC. Previous studies have reported that patients PDAC are more vulnerable to ferroptosis inducers. To investigate relationship between PSCs pancreatic cancer cells, coculture system used further reveal influence on resistance using many in vitro vivo experiments. Our results show promote cells. We demonstrate IL15 secretion by activates IL15RA-STAT3-GPX4/ACSL3 axis. The simultaneous upregulation GPX4 ACSL3 prevents lipid peroxidation ultimately protects from both vivo. This study demonstrates protect paracrine manner may indicate novel strategy

Language: Английский

Citations

3