Age‐related decline in GABAergic intracortical inhibition can be counteracted by long‐term learning of balance skills DOI Creative Commons
Yves‐Alain Kuhn, Sven Egger, Matteo Bugnon

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(15), P. 3737 - 3753

Published: July 1, 2024

Ageing induces a decline in GABAergic intracortical inhibition, which seems to be associated not only with decremental changes well-being, sleep quality, cognition and pain management but also impaired motor control. So far, little is known regarding whether targeted interventions can prevent the of inhibition primary cortex elderly. Therefore, present study investigated age-related cortical dis-inhibition could reversed after 6 months balance learning improvements postural control correlated extent dis-inhibition. The results demonstrated that upregulated elderly subjects long-term revealed correlation between performance inhibition. This first show physical activity-related upregulation population chronic may therefore seminal for many pathologies equilibrium inhibitory excitatory neurotransmitters disturbed. KEY POINTS: After learning, subjects. this

Language: Английский

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System DOI Open Access
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5954 - 5954

Published: May 25, 2022

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role information transmission throughout the nervous system. Hundreds of such chemicals have been discovered last century, continuing to be identified studied concerning their action on brain health. These substances observed influence numerous functions, including emotions, thoughts, memories, learning, movements. Thus, disturbances neurotransmitters' homeostasis started being correlated with a plethora neurological neurodegenerative disorders. In this respect, present paper aims describe most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) noncanonical neurotransmitters exosomes, steroids, D-aspartic acid), explain link some relevant conditions. Moreover, brief overview recently developed detection methods is offered, followed by several considerations modulation these towards restoring homeostasis.

Language: Английский

Citations

270
Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis DOI Creative Commons
Jody Rusch, Brian T. Layden, Lara R. Dugas

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 19, 2023

Cognitive function in humans depends on the complex and interplay between multiple body systems, including hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which vastly outnumbers human cells has a genetic potential that exceeds of genome, plays crucial role this interplay. microbiota-gut-brain (MGB) axis is bidirectional signalling pathway operates through neural, endocrine, immune, metabolic pathways. One major neuroendocrine systems responding to stress HPA produces glucocorticoids such as cortisol corticosterone rodents. Appropriate concentrations are essential for normal neurodevelopment function, well cognitive processes learning memory, studies have shown microbes modulate throughout life. Stress can significantly impact MGB via other Animal research advanced our understanding these mechanisms pathways, leading paradigm shift conceptual thinking about influence microbiota health disease. Preclinical trials currently underway determine how animal models translate humans. In review article, we summarize current knowledge relationship axis, cognition, provide an overview main findings conclusions broad field.

Language: Английский

Citations

117
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease DOI Creative Commons
Sara Hijazi, August B. Smit, Ronald E. van Kesteren

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 4954 - 4967

Published: July 7, 2023

Abstract Fast-spiking parvalbumin (PV) interneurons are inhibitory with unique morphological and functional properties that allow them to precisely control local circuitry, brain networks memory processing. Since the discovery in 1987 PV is expressed a subset of fast-spiking GABAergic neurons, our knowledge complex molecular physiological these cells has been expanding. In this review, we highlight specific neurons fire at high frequency reliability, enabling network oscillations shape encoding, consolidation retrieval memories. We next discuss multiple studies reporting neuron impairment as critical step neuronal dysfunction cognitive decline mouse models Alzheimer’s disease (AD). Finally, propose potential mechanisms underlying AD argue early changes activity could be causal AD-associated significant contributor pathogenesis.

Language: Английский

Citations

47
Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance DOI Creative Commons
Dnyandev Gadhave, Vrashabh V. Sugandhi, Saurav Kumar Jha

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102357 - 102357

Published: June 1, 2024

Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both medicine and public health in the upcoming years due global demographic changes. NDs mainly represented by degeneration/loss of neurons, which is primarily accountable severe mental illness. This neuronal degeneration leads many neuropsychiatric problems permanent disability an individual. Moreover, tight junction brain, blood-brain barrier (BBB)has protective feature, functioning as biological that can prevent medicines, toxins, foreign substances from entering brain. However, delivering any medicinal agent brain (i.e., Multiple sclerosis, Alzheimer's, Parkinson's, etc.) enormously challenging. There approved therapies address NDs, but most them only help treat associated manifestations. The available have failed control progression certain factors, i.e., BBB drug-associated undesirable effects. extremely complex pathology, with pathogenic mechanisms involved initiation progression; thereby, limited survival rate has been observed ND patients. Hence, understanding exact mechanism behind crucial developing alternative approaches improving patients' rates. Thus, present review sheds light on different cellular novel therapeutic their clinical relevance, will assist researchers alternate strategies limitations conventional therapies. current work offers scope into near future improve approach NDs.

Language: Английский

Citations

33
Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb,

Ali K. Albuhadily

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Parkinson's disease (PD) is a progressive neurodegenerative brain due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response the disturbance diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has neuroprotective effect against neuropathology by protecting DNs substantia nigra pars compacta (SNpc). It been shown that GABAergic linked progression neurotransmission necessary pathway for normal sleep patterns, thus deregulation could be potential cause disorders PD.

Language: Английский

Citations

18
Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders DOI Creative Commons
Rengasamy Balakrishnan, Duk-Yeon Cho, In‐Su Kim

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 281 - 281

Published: Jan. 29, 2022

Neurological disorders are important causes of morbidity and mortality around the world. The increasing prevalence neurological disorders, associated with an aging population, has intensified societal burden these diseases, for which no effective treatment strategies currently exist. Therefore, identification development novel therapeutic approaches, able to halt or reverse neuronal loss by targeting underlying causal factors that lead neurodegeneration cell death, urgently necessary. Plants other natural products have been explored as sources safe, naturally occurring secondary metabolites potential neuroprotective properties. α- β-asarone can be found in high levels rhizomes medicinal plant Acorus calamus (L.). exhibit multiple pharmacological properties including antioxidant, anti-inflammatory, antiapoptotic, anticancer, effects. This paper aims provide overview current research on particularly neurodegenerative diseases such Alzheimer’s disease (AD), Parkinson’s (PD), well cerebral ischemic disease, epilepsy. Current indicates exert effects mitigating oxidative stress, abnormal protein accumulation, neuroinflammation, neurotrophic factor deficit, promoting survival, activating various signalling pathways. Although beneficial exerted demonstrated through vitro vivo animal studies, additional is required translate laboratory results into safe therapies patients AD, PD, diseases.

Language: Английский

Citations

42
The GABAergic system in Alzheimer’s disease: a systematic review with meta-analysis DOI
Giovanna Carello‐Collar, Bruna Bellaver, Pâmela C.L. Ferreira

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 5025 - 5036

Published: July 7, 2023

Language: Английский

Citations

31
The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease DOI

Yuanhong Tang,

Yan Yan, Jian Mao

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101865 - 101865

Published: Jan. 28, 2023

Language: Английский

Citations

23
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons DOI
Monika Sharma, Pankaj Pal, Sukesh Kumar Gupta

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1829, P. 148797 - 148797

Published: Feb. 10, 2024

Language: Английский

Citations

15
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s disease DOI Creative Commons
Abdallah M. Eteleeb, Brenna C. Novotny, Carolina Soriano‐Tárraga

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(4), P. e3002607 - e3002607

Published: April 30, 2024

Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical neuropathological data from multiple human AD cohorts. We discovered 4 unique multimodal profiles, one them showing signs poor cognitive function, a faster pace disease progression, shorter survival disease, severe neurodegeneration astrogliosis, reduced levels metabolomic profiles. found this profile be present in affected cortical regions associated higher Braak tau scores significant dysregulation synapse-related genes, endocytosis, phagosome, mTOR signaling pathways altered early late stages. cross-omics integration transcriptomic an SNCA mouse model revealed overlapping signature. Furthermore, leveraged single-nuclei RNA-seq identify distinct cell-types that most likely mediate Lastly, identified clusters uncovered cerebrospinal fluid biomarkers poised monitor progression possibly cognition. Our analyses provide novel critical insights into AD.

Language: Английский

Citations

12