Perinatology, Journal Year: 2023, Volume and Issue: 34(4), P. 157 - 157
Published: Jan. 1, 2023
Language: Английский
Journal of Perinatal Medicine, Journal Year: 2024, Volume and Issue: 52(2), P. 202 - 209
Published: Jan. 4, 2024
Abstract Objectives We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born mothers with peripartum infection a German cohort, identify potential risk factors associated neonatal infection, and present short-term outcomes vertical transmission SARS-CoV-2. Methods Data on women occurring anytime during their pregnancy was gathered prospectively within CRONOS registry. From April 2020 February 2023 total 8,540 had been registered. The timing probability mother-to-child neonates perinatal were classified using WHO classification system. severity maternal vaccination status, type dominant virus, outcome parameters analyzed as for infection. Results 6.3 % resp. 42.9 tested stillbirths positive. 2.1 confirmed possible identified. Severe COVID-19 (odds ratio 4.4, 95 confidence interval 1.8–11.1) Delta virus (OR 3.2, 1.4–7.7) Newborns or significantly more often admitted NICU (65.2 vs. 27.5 non, p<0.001). Conclusions rate higher our cohort than previously reported, infections rare. Our data emphasizes confirmative testing should be performed infected an underlying pathology leading admission.
Language: Английский
Citations
7
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105844 - 105844
Published: Aug. 4, 2024
This systematic review explored the impact of maternal immune activation (MIA) on learning and memory behavior in offspring, with a particular focus sexual dimorphism. We analyzed 20 experimental studies involving rodent models (rats mice) exposed to either lipopolysaccharide (LPS) or POLY I:C during gestation following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Our findings reveal that most report detrimental MIA performance highlighting significant role prenatal environmental factors neurodevelopment. Furthermore, this underscores complex effects sex, males often exhibiting more pronounced cognitive impairment compared females. Notably, small subset enhanced function MIA, suggesting complex, context-dependent outcomes challenges. also highlights sex differences caused by terms cytokine responses, alterations gene expression, microglial responses as contribute observed.
Language: Английский
Citations
6
Discover Mental Health, Journal Year: 2023, Volume and Issue: 3(1)
Published: Aug. 22, 2023
Adverse influences during pregnancy are associated with a range of unfavorable outcomes for the developing offspring. Maternal psychosocial stress, exposure to infections and nutritional imbalances known risk factors neurodevelopmental derangements according psychiatric neurological manifestations later in offspring life. In this context, maternal immune activation (MIA) model has been extensively used preclinical research study how stimulation system gestation derails tightly coordinated sequence fetal neurodevelopment. The ensuing consequence MIA brain structure function majorly manifested behavioral cognitive abnormalities, phenotypically presenting periods adolescence adulthood. These observations have interpreted within framework "double-hit-hypothesis" suggesting that an elevated disorders results from individual being subjected two adverse environmental at distinct life, jointly leading emergence pathology. early postnatal period, which caregiving parent is major determinant newborn´s environment, constitutes window vulnerability external stimuli. Considering not only affects fetus, but also impinges on mother´s brain, state heightened malleability pregnancy, impact behavior postpartum may importantly contribute detrimental consequences her progeny. Here we review current information interaction between prenatal environments modulation development their relevance pathophysiology model.
Language: Английский
Citations
11
Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(2)
Published: Jan. 31, 2024
Abstract Epidemiologic studies suggest that prenatal exposures to certain viruses may influence early neurodevelopment, predisposing offspring neuropsychiatric conditions later in life. The long-term effects of maternal COVID-19 infection pregnancy on brain development, however, remain largely unknown. We prospectively enrolled infants an observational cohort study for a single-site the Washington, DC Metropolitan Area from June 2020 November 2021 and compared these pre-pandemic controls (studied March 2014–February 2020). primary outcomes are measures cortical morphometry (tissue-specific volumes), along with global regional local gyrification index, sulcal depth. studied 210 (55 unexposed mothers, 47 COVID-19-positive 108 healthy controls). found increased gray matter volume (182.45 ± 4.81 vs. 167.29 2.92) accelerated depth frontal lobe (5.01 0.19 4.40 0.13) mothers controls. additional differences suggesting both viral exposures, as well non-viral stressors associated pandemic, development warrant ongoing follow-up.
Language: Английский
Citations
4
Yonsei Medical Journal, Journal Year: 2024, Volume and Issue: 65(4), P. 202 - 202
Published: Jan. 1, 2024
In view of conflicting reports on the ability severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to infect placental tissue, this study aimed further evaluate impact inflammation and damage from symptomatic third-trimester maternal COVID-19 infection.
Language: Английский
Citations
4
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 420 - 420
Published: Jan. 10, 2025
Background: Despite considerable research on pregnancy outcomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the consequences for infants exposed to virus in utero remain unclear. Methods: A retrospective cohort study was conducted, encompassing 392 mother-infant pairs delivered between April 2020 and July 2021 at a community hospital network northeastern Pennsylvania, USA. Of these, 198 mothers had confirmed SARS-CoV-2 infection during pregnancy, while 194 did not. Infant were compared two groups. Results: Pregnant women with their gestation exhibited higher rates of obesity (p = 0.04) body mass indices (BMI) 0.01), more likely be Hispanic ethnicity history chronic hypertension 0.05), as well occurrences postpartum depression gestational diabetes cesarean section (CS) (p< 0.001), preeclampsia 0.04). Among reviewed, there no statistical significance difference developmental milestones 2, 4, 6, 9, 12 months age parturients who tested positive disease 2019 (COVID-19) without COVID-19 test result. There statistically significant groups outcomes, measured Ages Stages Questionnaire (ASQ) scores 9 0.76) 18 0.89). Conclusions: This corroborates adverse impact pregnant women, characterized increased maternal comorbidities birth outcomes. No disparities neonatal or growth observed birth; first office visit, 1, age.
Language: Английский
Citations
0
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
The COVID-19 pandemic has shown the critical importance of vaccination strategies to protect vulnerable populations, including pregnant women, from severe disease and its lingering consequences. Although growing evidence demonstrates that vaccines are both safe highly beneficial during pregnancy, vaccine hesitancy among women persists, partly fueled by persistent, decade-old "urban myth" linking pregnancy neuropsychiatric disorders in children. Here, we used a mouse model passive immunization with acute respiratory syndrome coronavirus 2 spike neutralizing monoclonal antibodies (SaCoV-AB) determine effects gestational on key outcomes, maternal offspring health, behavior. We show at higher SaCoV-AB dosage, immune response is reflected elevated TNF-α levels serum, but not placenta or fetal brain, no effect outcomes. report consequences for postpartum care behavior neonatal communication signatures. Behavioral assessment adult female male after treatment revealed differences phenotypes relevant neurodevelopmental disorders. Our findings indicate preclinical model, well-tolerated, discernable impact health
Language: Английский
Citations
0
American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 92(2)
Published: Aug. 1, 2024
Abstract Background The severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) outbreak in 2019 has necessitated investigating its potential adverse effects on pregnancy outcomes and fetal development. Objective This study aimed to review the evidence impact of SARS‐CoV‐2 infection during outcomes. Method Study Literatures since COVID‐19 from PubMed Web Science were summarized this narrative review, show maternal Results can be transmitted vertically through placenta, both utero perinatally, affecting maternal–fetal immune interface placental function. Viral infections have been linked central nervous system development impairments disorders such as autism. Changes structure function respiratory, immune, visceral systems also reported. with increased risks stillbirth preterm birth. However, mechanisms involved remain unclear may include cytokine storms, macrophage mediation, genetic mutations, methylation, other epigenetic changes. Exploring protective antiviral treatment interventions animal clinical studies help improve Conclusion activates vertical transmission, short‐ long‐term development, including system. Future provide that inform reduce risk
Language: Английский
Citations
2
Pediatric Research, Journal Year: 2023, Volume and Issue: 95(2), P. 445 - 455
Published: Dec. 6, 2023
Language: Английский
Citations
6
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(9), P. e2435005 - e2435005
Published: Sept. 23, 2024
Importance Stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Autism screening positivity for children born the pandemic remains unknown. Objective To examine associations between prenatal exposure to milieu maternal SARS-CoV-2 infection rates of positive Modified Checklist Toddlers, Revised (M-CHAT-R) screenings. Design, Setting, Participants Data this cohort study were drawn from COVID-19 Mother Baby Outcomes (COMBO) Initiative. M-CHAT-R scores obtained aged 16 30 months routine clinical care at Columbia University Irving Medical Center New York City abstracted electronic health records (EHRs) January 2018 September 2021 (COMBO-EHR cohort). Separately, was administered 18 February 2020 through a prospective longitudinal (COMBO-RSCH Prenatal (birth after March 1, 2020) status determined EHRs. analyzed 2022 June 2024. Exposures exposures infection. Main Measures The primary outcome rate For all analyses, unadjusted χ 2 tests adjusted logistic regression models performed. Results COMBO-EHR included 1664 (442 before 1222 pandemic; 997 unexposed, 130 exposed, 95 unknown status), whom 266 (16.0%) Black, 991 (59.6%) Hispanic, 400 (24.0%) White, 1245 (74.8%) insured Medicaid, 880 (52.9%) male, 204 (12.3%) prematurely. COMBO-RSCH 385 (74 311 201 101 9 39 (10.1%) 168 (43.6%) 157 (40.8%) 161 (41.8%) 222 (57.7%) 38 (9.9%) not higher either or cohort. lower (12.3% [16 children] vs 24.0% [239 children]; odds ratio, 0.40; 95% CI, 0.22-0.68; P = .001), but no association found (12.9% [13 19.9% [40 0.51; 0.24-1.04; .07). Conclusions Relevance In groups and/or infection, neither greater positivity.
Language: Английский
Citations
1