Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Genes & Diseases, Journal Year: 2022, Volume and Issue: 10(4), P. 1367 - 1401

Published: March 18, 2022

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions deaths every year. With the new understanding molecular mechanism(s) disease progression, our knowledge about snowballing, leading to evolution many therapeutic regimes their successive trials. In past few decades, various combinations therapies have been proposed are presently employed in treatment diverse cancers. Targeted drug therapy, immunotherapy, personalized medicines now largely being employed, which were not common a years back. The field cancer discoveries therapeutics evolving fast as type-specific biomarkers progressively identified several types cancers nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows targeted approach could be future medicine, chemotherapy remains opted option despite its known side effects on patient's physical psychological health. Chemotherapeutic agents/pharmaceuticals served great purpose over decades remained frontline choice for advanced-stage surgery and/or radiation therapy cannot prescribed due specific reasons. present report succinctly reviews existing contemporary advancements assesses status enrolled drugs/pharmaceuticals; it also comprehensively discusses emerging role specific/targeted strategies achieve better clinical success/survival rate patients.

Language: Английский

---

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112175 - 112175

Published: Sept. 27, 2021

Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for long time. Traditional uses of this plant indicate its ameliorative properties against plethora human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents comprehensive summary the geographical distribution, use, phytochemistry, and pharmacological activities W. active constituents. In addition, it detailed account presence an constituent in many commercial preparations with curative health benefits. Clinical studies toxicological considerations extracts constituents are also elucidated. Comparative analysis relevant in-vitro, in-vivo, clinical investigations indicated potent bioactivity phytochemicals anti-cancer, anti-inflammatory, apoptotic, immunomodulatory, antimicrobial, anti-diabetic, hepatoprotective, hypoglycaemic, hypolipidemic, cardio-protective spermatogenic agents. was found to be especially neurological psychological conditions like Parkinson's disease, Alzheimer's Huntington's ischemic stroke, sleep deprivation, amyotrophic lateral sclerosis, attention deficit hyperactivity disorder, bipolar anxiety, depression, schizophrenia obsessive-compulsive disorder. The probable mechanism action that imparts potential explored. However, in-depth needed on use diseases. Besides, is performed safe efficacious preclinical health-promoting herb.

Language: Английский

---

Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives – A review

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 284, P. 114744 - 114744

Published: Oct. 15, 2021

Traditional knowledge is a particular form of practice or skill set that was developed in ancient times and sustained through generations via the passing knowledge, essentially confined within specific tribe, local people, family lineages. Ethnodermatological use medicinal plants India still subject to conduct more studies see if there chemical, microbiological, and/or clinical evidence, from scientific perspective, their effectiveness for those skin disorders. Thus, this review can be basis further may provide targets drug development. We compile emphasize most important part ethnodermatology, namely, traditional applications several diseases India. also include brief explanation on dermatology Ayurvedic Unani medicine. pharmacological activity extracts derived some cited against problem as well. Different kinds key phrases such "Indian ethnodermatology", "ethnodermatology", "ethnobotany", "skin diseases", "Ayurveda dermatology", "pharmacological activity" were searched online search servers/databases Google Scholar (https://scholar.google.com/), ResearchGate (https://www.researchgate.net/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), NISCAIR Online Periodicals Repository (NOPR) (http://nopr.niscair.res.in/). Based upon analyses data obtained 178 articles, we formulated findings which are summary shown Tables. A total 119 records plants' uses have been found across 39 diseases. These depicted with localities report, parts used, preparation administration methods The utilisation herbal medicine Indian subcontinent has great potential treat different human plant species used topical few only administrated orally. investigated mice, bacterial fungal pathogens, cells. Complementary therapy dermatological problems treatment remains main option millions people subcontinent. This practices ethnobotanical confirms belief analysis will accelerate discovery new, effective therapeutic agents However, evidence required determine identified contribute condition treatment, particularly atopic eczema. Today, ethnodermatology well-accepted international discipline many new initiated numerous countries. hope article development area identify generation natural treatments help meet growing consumer demand safe, sustainable, treatments. In context, research utilised elsewhere should intensified.

Language: Английский

---

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Journal of Cellular and Molecular Medicine, Journal Year: 2022, Volume and Issue: 26(11), P. 3083 - 3119

Published: May 2, 2022

Piper betle L. (synonym: betel Blanco), or vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as green gold. The plant can be found all over world is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed consumed betelquidand widely used Chinese Indian folk medicine, carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also religious purposes. Hydroxychavicol most bioactive compound among wide range of phytoconstituents essential oil extracts. pharmacological attributes P. antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal many more. Immense attention has been paid nanoformulations their applications. application did not show cytotoxicity preclinical experiments, suggesting that it could serve a promising therapeutic candidate different diseases. present review comprehensively summarizes botanical description, geographical distribution, economic value cultivation, ethnobotanical uses, properties with insights toxicological, clinical efficacy, safety betle. findings suggest represents orally active safe natural agent exhibits great potential managing various human medical conditions. However, further research needed elucidate underlying molecular mechanisms action, aspects, structure-activity relationships, bioavailability synergistic interactions other drugs.

Language: Английский

---

Cellular landscaping of cisplatin resistance in cervical cancer

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113345 - 113345

Published: July 8, 2022

Language: Английский

---

Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Advances in Medicine, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 10

Published: March 14, 2023

Malaria continued to be a deadly situation for the people of tropical and subtropical countries. Although there has been marked reduction in new cases as well mortality morbidity rates last two decades, reporting malaria caused 247 million 619000 deaths worldwide 2021, according WHO (2022). The development drug resistance declining efficacy against most antimalarial drugs/combination current clinical practice is big challenge scientific community, absence an effective vaccine, problem becomes worse. Experts from various research organizations are continuously working hard stop this disaster by employing several strategies drugs/combinations. review focuses on history discovery advantages, loopholes, opportunities associated with common being followed development.

Language: Английский

---

Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

Horticulture Research, Journal Year: 2023, Volume and Issue: 10(9)

Published: July 26, 2023

Is Cannabis a boon or bane? sativa has long been versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). faced global prohibition in the twentieth century because of psychoactive properties ∆9-tetrahydrocannabinol; however, recently, perspective changed with recognition additional therapeutic values, particularly pharmacological potential cannabidiol. A comprehensive understanding underlying mechanism cannabinoid biosynthesis is necessary to cultivate promote globally medicinal application resources. Here, we comprehensively review historical usage Cannabis, trichome-specific cannabinoids, regulatory network trichome development, synthetic biology cannabinoids. This provides valuable insights into efficient green production development utilization novel varieties.

Language: Английский

---

Dioscin: A review on pharmacological properties and therapeutic values

BioFactors, Journal Year: 2021, Volume and Issue: 48(1), P. 22 - 55

Published: Dec. 16, 2021

Abstract Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease‐associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, efficient treatment alternatives. Natural compounds can contribute vastly this field. Over recent years, studies have demonstrated the remarkable protective actions dioscin against variety malignancies, metabolic disorders, organ injuries, viral/fungal infections. successful usage phytocompound been widely seen in procedures under traditional Chinese medicine, it is becoming progressively prevalent worldwide. This review provides insight into wide spectrum pharmacological activities dioscin, reported compiled literature. various novel approaches applications also verify advantages exhibited by plant extracts commercially available drugs, highlighting potential phytochemical agents like be further incorporated clinical practice.

Language: Английский

---

Hemp and Its Derivatives as a Universal Industrial Raw Material (with Particular Emphasis on the Polymer Industry)—A Review

Materials, Journal Year: 2022, Volume and Issue: 15(7), P. 2565 - 2565

Published: March 31, 2022

This review article provides basic information about cannabis, its structure, and impact on human development at the turn of century. It also contains a brief description cultivation application these plants in branches economy. overview is comprehensive collection chemical composition individual cannabis derivatives. characteristics as well physicochemical mechanical properties hemp fibers, oil, extracts wax, which unique compared to other articles. As one few articles, it approaches topic holistic evolutionary way, moving through plant's life cycle. Its important element examples use derivatives polymer composites based thermoplastics, elastomers duroplasts influence additives their properties, cannot be found articles this subject. indicates possible directions for further technological development, with particular emphasis pro-ecological aspects plants. gaps research knowledge elastomers.

Language: Английский

---

Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging

The Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 227(Supplement_1), P. S38 - S47

Published: March 15, 2023

Language: Английский

---