Suvorexant with or without ramelteon to prevent delirium: a systematic review and meta‐analysis

Psychogeriatrics, Journal Year: 2021, Volume and Issue: 22(2), P. 259 - 268

Published: Dec. 8, 2021

Abstract Delirium is a common and serious neurobehavioral syndrome, associated with prolonged hospital stays, increased morbidity mortality. As it remains unclear whether suvorexant or without ramelteon prevents delirium in elderly hospitalized patients, we conducted systematic review meta‐analysis to evaluate, searching the PubMed, Cochrane Library, Web of Science, EMBASE, EBSCOhost databases for all randomized controlled trials (RCTs), case–control studies, cohort studies that investigated effects on adult patients. The primary outcome was incidence delirium. Two trials, 7 2 involving 2594 patients were included this meta‐analysis. results showed both alone (odds ratio (OR) = 0.30, 95% confidence interval (CI): 0.14–0.65, P 0.002) (OR 0.39, CI 0.23–0.65, 0.0003) reduced Six involved use benzodiazepines; subgroup analysis performed separately groups indicated when benzodiazepine administered, effective at reducing 0.53, 0.37–0.74, 0.0002), but no significant difference observed 0.40, 0.11–1.53, 0.18). current literature thus supports effectiveness prevention, although failed significantly reduce administered. present study limited by heterogeneity among caution should be exercised interpreting results. This registered PROSPERO database (CRD4202017964).

Language: Английский

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The Effectiveness of Using Breathing Exercise on Sleep Quality Among Hospitalized Patients

American Journal of Nursing Science, Journal Year: 2020, Volume and Issue: 9(4), P. 272 - 272

Published: Jan. 1, 2020

Sleep disturbance among hospitalized patients has many factors especially at critical care units. Daily breathing exercises as pursed lip (PLB) and diaphragmatic improves sleep quality reduces the occurrence of delirium. Aim study Evaluate effectiveness using exercise on patients. Design quasi experimental design. Sample A purposive sample including 152 were divided into four equal groups two from Medical ward (study control) 38 each group form Intensive Care Unit (MICU) Minia university hospital. Results majority male; all in middle age. (39% 44.7%) medical (52.6% respectively MICU had sever problem. But after applying for 3 continuous days, (44.7%) (50%) great quality. Majority group’s no Confusion,” with percentage (60.5% 52.6%) which mean presence Conclusion significance effect improving sleeping reduce delirium than control groups.

Language: Английский

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Prophylactic Melatonin for Delirium in Intensive Care Unit: An updated Systematic Review and Meta-analysis of Randomized Controlled Trials

Indian Journal of Critical Care Medicine, Journal Year: 2023, Volume and Issue: 27(9), P. 675 - 685

Published: Aug. 31, 2023

Introduction: Delirium, being a common disorder among critically ill patients, has reported incidence ranging 45-83% in the intensive care unit (ICU) population.The prophylactic use of melatonin and melatonergics been shown to have positive effect reducing delirium many clinical trials.Our study was thus proposed find out role on severity ICU delirium, hospital length stay (LOS), requirement, duration mechanical ventilation, mortality.Methodology: A systematic search various databases performed trials which compare with placebo or standard therapy for prevention results conveyed as mean differences (MDs) risk ratios.The statistical software, Review Manager (RevMan, version 5.4), used data synthesis.Results: Twelve studies were included meta-analysis.Prophylactic administration ramelteon not associated statistically significant reduction (odds ratio [OR] 0.63; confidence interval [CI]: 0.60, 1.32; p = 0.22), (MD: 0.22; 95% CI: From -1.36 1.81; 0.78), LOS 0.05; -0.65 0.75; 0.89), -1.46; -4.50 -1.59; 0.35), need ventilation (OR: 0.74, 0.38-1.44;p 0.37), mortality 0.78; 0.56; 1.11; 0.62).However, -0.85; -1.64 -0.06; 0.03) found.Conclusion: Our meta-analysis suggests that when given prophylactically no LOS, mortality.Further are warranted.

Language: Английский

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Sleep Disturbances in Individuals Quarantined Due to SARS-CoV-2 Pandemic in Poland: A Mixed Methods Design Study

Global Advances in Health and Medicine, Journal Year: 2021, Volume and Issue: 10

Published: Jan. 1, 2021

Objectives The study aimed to assess sleep disturbances in patients subjected home quarantine due suspected SARS-CoV-2 infection. used a mixed methods design as research methodology. Methods A semi-structured interview and the scale for Insomnia Severity Index (ISI) were achieve aim of study. survey was conducted from 16 20 April 2020 1 2 September Poland, at during epidemic this country. data coded cross-processed. (COREQ) checklist followed. Results Interviews with thorough analysis recordings revealed commonly phrases following categories: “anxiety”, “ Am I going crazy?”, “Sleep problems”. 10 out 11 respondents reported disorders varying severity according scale. Patients presented fear related return society normal functioning after quarantine. Additionally, some participants voiced concerns their mental health; cases hallucinations reported. Conclusions Further global population studies should be analyse phenomenon. Acute Stress Disorder understood threat life health an isolated area promoted need guidelines entire developed.

Language: Английский

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Optimizing Sleep and Circadian Health in the NeuroICU

Current Treatment Options in Neurology, Journal Year: 2022, Volume and Issue: 24(8), P. 309 - 325

Published: July 15, 2022

Language: Английский

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