Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Nutrients, Journal Year: 2022, Volume and Issue: 14(5), P. 1076 - 1076

Published: March 3, 2022

Background: Vitamin D deficiency is associated with sleep disorders and poor quality. Whether vitamin supplementation (VDS) helps resolve these problems remains unclear. Objective: To systematically review the effect of VDS on quantity, quality, disorders, perform a meta-analysis available data. Methods: The reporting this followed PRISMA statement. human interventions studies that reported or were included. Medline, CINAHL, EMBASE, PsycInfo, Cochrane Library, Clinicaltrials.gov, ICTRP searched, in addition to references included articles previous relevant reviews, without language time restrictions. Included critically appraised, findings narratively synthesized, was conducted. Furthermore, overall certainty evidence assessed. Results: A total 19 (13 randomized controlled trials (RCTs), 1 opportunistic an RCT, 4 pre−post studies, study analyzed as case series); 3 RCTs meta-analyses. risk bias generally low. Pre−post showed significant improvement quality VDS. Similarly, results revealed statistically decrease Pittsburgh Sleep Quality Index compared placebo (mean difference, −2.33 (95% CI, −3.09, −1.57); p < 0.001; I2 = 0%), moderate evidence. regarding sleep-related impairment, difficulty, well sleepiness restless legs syndrome, not unanimous. Conclusions: promising improving quality; however, its quantity needs be further investigated.

Language: Английский

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Climatic and meteorological exposure and mental and behavioral health: A systematic review and meta-analysis

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 892, P. 164435 - 164435

Published: May 29, 2023

Language: Английский

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Sleep Deprivation and Gut Microbiota Dysbiosis: Current Understandings and Implications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9603 - 9603

Published: May 31, 2023

Gut microbiota comprises the microbial communities inhabiting our gastrointestinal (GI) tracts. Accordingly, these complex play a fundamental role in many host processes and are closely implicated human health diseases. Sleep deprivation (SD) has become increasingly common modern society, partly owing to rising pressure of work diversification entertainment. It is well documented that sleep loss significant cause various adverse outcomes on including immune-related metabolic Furthermore, accumulating evidence suggests gut dysbiosis associated with SD-induced In this review, we summarize caused by SD succedent diseases ranging from immune system organs highlight critical roles The implications possible strategies alleviate SD-related also provided.

Language: Английский

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Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117972 - 117972

Published: Feb. 23, 2024

Language: Английский

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NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 4, 2025

Language: Английский

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Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33

Published: Jan. 17, 2025

A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules

Language: Английский

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Drivers of individual differences in the sleep behaviour of fallow deer neonates

Journal of Animal Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Inter‐individual differences are necessary for selection to act, while plasticity (intra‐individual variation) may buffer against selection. Sleep is a critical self‐maintenance behaviour but, unlike most behaviours, the causes and consequences of its inter‐ intra‐individual variation in wild animals poorly understood, particularly neonates where sleep plays key role development. We have shown previously that free‐ranging neonate fallow deer ( Dama dama ) differ during first few weeks life. Here, we test whether individual variability organised systematically across population, these associated with chronic stress measured using hair cortisol, or timing birth. Four dimensions (total time, fragmentation, quality, distribution over 24‐h) were quantified state‐of‐the‐art triaxial accelerometers. then used multivariate mixed‐effects model Bayesian framework evaluate covariation between multiple behaviour, quantify relative importance birth, accounting confounding effects environmental conditions age. found birth not changes individuals. While both total time number bouts per day declined age, their rate development covaried, but no other covaried. Our results represent an in‐depth analysis natural sleep, show four aspects architecture free‐living fawns strong independent one another unrelated suggest might emerge later life cortisol be very short transient.

Language: Английский

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Assessing the best hour to start the day: an appraisal of seasonal daylight saving time

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(3)

Published: March 1, 2025

We provide an evidence-based position on the seasonal regulation of clocks daylight saving time (DST) that challenges papers by sleep associations against practice. review acute, short-term impact and chronic, long-term DST in context changing ambient light conditions characterize seasons at Extratropical latitudes. highlight association between DST, human physiology (photoreceptive mechanisms) daily life. offer a perspective possible scenarios should clock regulations be abandoned.

Language: Английский

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Soy isoflavones protects against cognitive deficits induced by chronic sleep deprivation via alleviating oxidative stress and suppressing neuroinflammation

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(5), P. 2072 - 2080

Published: April 3, 2022

Mounting evidence suggests that there is a close association between chronic sleep deprivation (CSD) and cognitive deficits. The animal model of CSD-induced deficits commonly used to seek potential treatments. Soy isoflavones (SI) have been reported possess antioxidant, anti-inflammation, neuroprotective effects. In the present study, effects SI on memory impairment were investigated. mice subjected interruption apparatus continuously deprived for 2 weeks, while orally administrated with (10, 20, 40 mg/kg) or Modafinil (MOD,100 during CSD process. Immediately after SD protocol, performance was evaluated by object location recognition (OLR) test, novel (NOR) Morris water maze (MWM) task, as well hippocampus, extracted evaluation oxidative stress parameters inflammation levels through biochemical parameter assay western blotting analysis. results showed administration remarkably improved CSD-treated in OLR, NOR, MWM tests. addition, significantly elevated total antioxidant capacity superoxide dismutase enzyme activities, decreased malondialdehyde level, promoting element nuclear erythroid-2-related factor 2, its downstream targets, including heme oxygenase 1, quinone oxidoreductase 1 protein expressions. Moreover, treatment suppressed kappa B p65, nitric oxide synthase, cyclooxygenase activation, pro-inflammatory cytokines (Tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6], interleukin-1β [IL-1β]) release hippocampus mice. summary, current study provides an insight into CSD.

Language: Английский

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Sleep and allostatic load: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 64, P. 101650 - 101650

Published: May 28, 2022

The detrimental effects of sleep disturbances on health and wellbeing are well-established but not fully understood. allostatic load model has been suggested as a framework for understanding the adverse disturbances. We conducted systematic review meta-analysis to examine associations disturbance duration with load. PubMed, PsycINFO, Embase, Web Science were searched records relating published from 1993 January 14th, 2022. Two independent raters screened 395 titles abstracts 51 full texts. Data extracted 18 studies that assessed methodological quality. Of these, 17 26,924 participants included in meta-analysis. Sleep was significantly associated higher (effect size correlation [ESr] = 0.09, p < 0.001), association weaker samples larger proportion women. When compared normal sleep, long (ESr 0.12, 0.003). Results indicated heterogeneity. No found short 0.05, 0.069) or -0.06, 0.36). Future research should identify mechanisms directionality longitudinal studies.

Language: Английский

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