Association between Scabies Treatment and Parkinson’s Disease: A Nationwide, Population-Based Study DOI Creative Commons
Kao-Sung Tsai, Ming‐Kuei Lu, Chao-Hong Liu

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1342 - 1342

Published: Oct. 8, 2024

Scabies is typically treated with scabicides like lindane, which poses a risk for acute neural toxicity. Lindane's prolonged use, particularly in agriculture, linked to neurodegenerative diseases, including Parkinson's disease (PD), the second most common disorder. This study aimed evaluate whether scabies patients, those topical are at increased of developing PD.

Language: Английский

Sleep characteristics and risk of Alzheimer’s disease: a systematic review and meta-analysis of longitudinal studies DOI

Shichan Wang,

Xiaoting Zheng, Jingxuan Huang

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(7), P. 3782 - 3793

Published: April 24, 2024

Language: Английский

Citations

11
Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis DOI Creative Commons
Zoltán Ungvári, Mónika Fekete,

Andrea Lehoczki

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, neurodegenerative diseases such Alzheimer’s disease (AD) vascular impairment dementia (VCID). However, the extent specificity of these associations remain uncertain. This meta-analysis evaluates impact common disorders on risk developing decline. A comprehensive search literature was conducted identify prospective cohort studies assessing risk. Studies reporting estimates for AD, or decline associated with insomnia, other (e.g., restless legs syndrome, circadian rhythm excessive daytime sleepiness) were included. Meta-analyses performed using a random-effects model calculate pooled hazard ratios (HRs) 95% confidence intervals (CIs). Thirty-nine included, subgroup analyses showing between all-cause apnea (HR 1.33, CI 1.09–1.61), 1.36, 1.19–1.55), 1.24–1.43). Obstructive increased AD 1.45, 1.24–1.69), though its association did not reach statistical significance 1.35, 0.99–1.84). Insomnia significantly both 1.59, 1.01–2.51) 1.49, 1.27–1.74). highlights critical role in risk, emphasizing need early detection management disturbances. Targeted interventions could play pivotal reducing among high-risk populations.

Language: Английский

Citations

1
Distinguishing essential tremor from Parkinson’s disease: clinical and experimental tools DOI
Luca Angelini, Giulia Paparella, Matteo Bologna

et al.

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(8), P. 799 - 814

Published: July 17, 2024

Introduction Essential tremor (ET) and Parkinson's disease (PD) are the most common causes of prevalent movement disorders, with overlapping clinical features that can lead to diagnostic challenges, especially in early stages.

Language: Английский

Citations

5
Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models DOI Creative Commons
Gowoon Son, Thomas C. Neylan, Lea T. Grinberg

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 10, 2024

Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The rhythm, recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given investigating tauopathy-driven neuropathology SCN repercussions gene dysfunction brain affected tauopathies. This review aims provide an overview current literature on vulnerability tauopathies humans. Emphasis placed elucidating neuronal glial changes contributing widespread disruption molecular clock. Furthermore, this identifies areas knowledge requiring further investigation.

Language: Английский

Citations

4
Insomnia and Female Reproductive Diseases: A Cross-Sectional and Mendelian Randomization Study DOI Creative Commons
Liyuan Fang, Yan Wang, Runxi Wang

et al.

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 439 - 447

Published: Feb. 1, 2025

Insomnia is increasingly emerging as a significant concern in public health, with longstanding emphasis on its relationship overall well-being. Nevertheless, few research has been devoted to investigating the between insomnia and female reproductive health. In our study, we conducted Mendelian randomization (MR) study estimate causal diseases. A total of 268 independent genetic variants associated at genome-wide significance level (P < 5×10-8) were used instrumental variables. Summary-level data obtained from UK Biobank Finn Gen including ovarian cysts, polycystic syndrome (PCOS), endometriosis, premature insufficiency (POI), cancer (OC), uterine fibroids, endometrial (EC) infertility. We performed logistic regression assess associations risk OC EC by using National Health Nutrition Examination Survey (NHANES) 2013-2014. Our reveals that liability constitutes factor for cysts (odds ratio [OR]: 1.44, 95% confidence interval [CI]: 1.21-1.72, P< 0.05), PCOS (OR: 1.67, CI: 1.44-1.94, endometriosis 1.43, 1.16-1.76, 0.05). However, found no statistically POI, OC, EC, or Additionally, body mass index (BMI) was mediate about 10% effect PCOS. Moreover, cross-sectional not EC. provides evidence genetically predicted increases PCOS, endometriosis. Accordingly, potential weight control good sleep keeping fit need be emphasized.

Language: Английский

Citations

0
Sleep disturbances are related to glymphatic dysfunction in blepharospasm DOI

Zhengkun Yang,

Shuai Gong,

Jiana Zhang

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease DOI
Pratima Khandayataray, Meesala Krishna Murthy

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Insomnia and risk of all-cause dementia: A systematic review and meta-analysis DOI Creative Commons

Mingxian Meng,

Xiaoxia Shen,

Yan‐Ming Xie

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0318814 - e0318814

Published: April 9, 2025

Background The evidence on the relationship between insomnia and risk of dementia, Alzheimer’s disease (AD), Vascular dementia (VD) is not consistent. We conducted this meta-analysis to examine for developing AD, or VD in patients with all subtypes insomnia. Methods A comprehensive search PubMed, Embase, Cochrane Library was using following strings: ‘Insomnia OR Sleep initiation Maintenance disorders Early morning awakening’ AND ‘Dementia Disease Dementia’ ‘Risk’. Data extraction done independently by two researchers. Pooled odds ratio (OR) accompanied 95% confidence interval (CI) were calculated either a random-effects model fixed-effects model. Sensitivity analyses performed assess robustness findings. potential publication bias evaluated through Egger’s test Begg’s test. Results This included 16 studies combined sample size over 9 million individuals. revealed significant association (OR = 1.36; CI: 1.01-1.84), increased risks AD 1.52; 1.19-1.93) 2.10; CI 2.06-2.14). Subgroup showed no associations initial 1.01; 0.71-1.31), sleep-maintenance 0.88; 0.66-1.17), early awakening 0.94; 0.83-1.07) risk. Insomnia from Europe 1.24; 1.14-1.35), Asia 2.19; 2.06-2.32), Americas 1.05; 1.04-1.07) had varying dementia. Subgroups less than five years follow-up 2.16; 1.81-2.60) exhibited higher patients, while those more 1.17; 1.03-1.33) lower Conclusion Our reveals that linked VD. These findings suggest may significantly contribute all-cause highlighting importance intervention management Despite our efforts minimize explore sources heterogeneity, it still remained, therefore results should be interpreted caution.

Language: Английский

Citations

0
Chronic intermittent hypoxia exposure induces a unique microglial transcriptome in 5XFAD mice DOI
Kaitlyn M. Marino,

Andrea Ewald,

James W. Lash

et al.

Published: April 21, 2025

Abstract Clinical observations suggest that obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) pathology may be linked; however, causal mechanisms relationships are unclear. To investigate the potential interaction between amyloidosis intermittent hypoxia (IH), a hallmark of OSA, starting at 4-months age 5XFAD mice were exposed to chronic IH (CIH) consisting 20 episodes per hour for 12 hours/day, daily 4- (males) or 6-months (females). CIH did not induce significant changes in amyloid burden number astrocytes males females, but there was slight decrease microglia observed cortex both sexes. further explore this effect, we performed bulk RNA sequencing on isolated microglia. In WT mice, most robust gene induced by identified male microglia, many which pro-inflammatory. from compared NX, exposure comparatively more DEGs males. Further, genes upregulated vs sexes, an enrichment pathways associated with oxidative phosphorylation, aerobic cellular respiration, ATP synthesis. These indicate has effect microglial transcriptome than suggesting synergy AD OSA pathologies driven metabolic transcriptome. particularly interesting given known sex differences human disease.

Language: Английский

Citations

0
Neuroprotective Potential of Melatonin: Evaluating Therapeutic Efficacy in Alzheimer's and Parkinson's Diseases DOI Open Access
Norris C Talbot,

Patrick M. Luther,

Noah J Spillers

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 22, 2023

Decreased melatonin levels have been linked to both Alzheimer's disease (AD) and Parkinson's (PD), which are the two most prevalent neurodegenerative disorders. The development of sleep disorders is widespread in patients diagnosed with AD or PD. In this regard, calcification pineal gland, typically seen third decade, has associated a reduction production. Recent studies suggested that exogenous application can be utilized treat diseases. Furthermore, research shown deficiencies PD begin before diagnosis either made. These findings could encourage further on as potential biomarker for possible area early treatment these Many clinical also produced data denoting method reduce detrimental neurocognitive effects Further role diseases expand symptomatic prophylactic options such This review investigates melatonin's physiological properties, its PD, current therapeutic benefits patients.

Language: Английский

Citations

9