Sleep Quality and Sleep Hygiene as Predictors of Mental Health among University Students DOI Creative Commons
Nudra Malik,

Iqra Ashiq,

Raumish Masud Khan

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 13(1), P. 675 - 685

Published: March 30, 2024

Sleep is an integral human need. A significant public health issue getting little sleep, which harms health. University students are one of the groups most at risk for poor sleep quality and chronic loss, could influence both physical mental Students frequently report having persistent issues may exhibit hygiene habits. However, research has investigated role good habits concerning The present study explores relationship between hygiene, quality, among university students. design was cross-sectional, sample chosen using a non-probability convenience sampling strategy. Sample comprised (N= 210). scale positive health, index, general were used data collection. Results revealed correlation Both found to be predictors gender difference male female These findings can provide information about link variables interventions developing amongst It help improve this at-risk population.

Language: Английский

Dual sources of melatonin and evidence for different primary functions DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Dun‐Xian Tan

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 14, 2024

This article discusses data showing that mammals, including humans, have two sources of melatonin exhibit different functions. The best-known source melatonin, herein referred to as Source #1, is the pineal gland. In this organ, production circadian with maximal synthesis and release into blood cerebrospinal fluid occurring during night. Of total amount produced in we speculate less than 5% synthesized by rhythm has primary function influencing clock at level suprachiasmatic nucleus (the CSF melatonin) clockwork all peripheral organs via receptor-mediated actions. A second (Source # 2) from multiple tissues throughout body, probably being mitochondria these cells. constitutes bulk mammals concerned metabolic regulation. review emphasizes action determining re-dox homeostasis, but it other critical effects well. Extrapineal does not a released acts locally its cell origin possibly paracrine matter on adjacent factors control/influence extrapineal sites are unknown. We propose concentration cells determined subcellular redox state may be inducible under stressful conditions plant

Language: Английский

Citations

24
Therapeutic Use of γ-Hydroxybutyrate: History and Clinical Utility of Oxybates and Considerations of Once- and Twice-Nightly Dosing in Narcolepsy DOI Creative Commons
Thomas Roth

CNS Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Narcolepsy is a rare and chronic hypersomnolence disorder characterized by excessive daytime sleepiness, disrupted nighttime sleep, sleep paralysis, hypnagogic hallucinations occurs with or without cataplexy. Orexin neuron loss has been implicated in the underlying pathophysiology of narcolepsy type 1 through dysregulation sleep/wake patterns rapid eye movement sleep. γ-Aminobutyric acid (GABA) shown to play role modulation orexin neuronal activity during transitions from wakefulness γ-Hydroxybutyrate (GHB), an endogenous analog GABA, demonstrated therapeutic benefit treatment early investigations, but use historically limited owing existing stigma related illicit abuse risk. Initial regulatory approval its sodium salt derivative, oxybate (SXB), for cataplexy patients occurred 2002, additional formulations have developed. The efficacy safety SXB supported decades clinical research. This review discusses history application GHB derivatives individuals narcolepsy, including effect on

Language: Английский

Citations

1
Sleep regularity and major adverse cardiovascular events: a device-based prospective study in 72 269 UK adults DOI Creative Commons
Jean‐Philippe Chaput, Raaj Kishore Biswas, Matthew Ahmadi

et al.

Journal of Epidemiology & Community Health, Journal Year: 2024, Volume and Issue: unknown, P. jech - 222795

Published: Nov. 27, 2024

Background This study examines the associations between device-measured sleep regularity and risk of major adverse cardiovascular events (MACE), aims to determine whether sufficient duration attenuates or eliminates effects irregular on MACE risk. Methods A prospective cohort adults aged 40–79 years from UK Biobank who wore wrist-attached accelerometers for 7 days was conducted. Sleep Regularity Index (SRI) scores were calculated each participant using a validated algorithm, categorised as (SRI <71.6), moderately 71.6 87.3), regular >87.3 (reference group)). Information its subtypes (myocardial infarction, heart failure, stroke) obtained inpatient hospitalisation death records. Results We analysed data 72 269 individuals followed 8 years, without previous history an event in first year follow-up. Irregular (HR 1.26, 95% CI 1.16 1.37) sleepers 1.08, 1.01 1.70) at higher compared with sleepers. Dose-response analyses treating SRI continuous measure showed that associated near-linear fashion, steeper reduction (better) scores. Joint meeting age-specific recommendation offsets 1.07, 0.96 1.18), but not 1.19, 1.06 1.35). Conclusions strongly Adequate offset these among supports inclusion public health guidelines clinical practice factor disease.

Language: Английский

Citations

7
State of the Science: The Transdiagnostic Intervention for Sleep and Circadian Dysfunction DOI
Allison G. Harvey,

Laurel D. Sarfan

Behavior Therapy, Journal Year: 2024, Volume and Issue: 55(6), P. 1289 - 1302

Published: March 4, 2024

Language: Английский

Citations

6
Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank DOI
Sina Kianersi, Heming Wang, Tamar Sofer

et al.

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(9), P. 1647 - 1655

Published: July 17, 2024

To evaluate the association between irregular sleep duration and incident diabetes in a U.K. population over 7 years of follow-up.

Language: Английский

Citations

6
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study DOI
Sirimon Reutrakul, Jason C. Park, J. Jason McAnany

et al.

Diabetologia, Journal Year: 2024, Volume and Issue: 67(6), P. 1114 - 1121

Published: Feb. 27, 2024

Language: Английский

Citations

5
Too little or too much: nonlinear relationship between sleep duration and daily affective well-being in depressed adults DOI Creative Commons

Sun Ah Lee,

Dahlia Mukherjee, Jonathan Rush

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 25, 2024

Abstract Background In addition to having higher negative affect and lower positive overall, depressed individuals exhibit heightened affective reactivity external stimuli than non-depressed individuals. Sleep may contribute day-to-day fluctuations in individuals, given that sleep disturbance is a common symptom of depression. Yet, little known about changes daily as function nightly duration adults adults. The current study examined whether how naturally-occurring associated with affect, these associations differ between vs. Methods Data were drawn from the second wave National Study Daily Experiences (NSDE), diary project Midlife United States (MIDUS) study. sample 2,012 (M age =56.5; 57% female; 84% white) completed eight-day interviews via telephone on their experiences including affect. They also assessments Composite International Diagnostic Interview-Short form, status was determined based DSM-III. Multilevel regression models linear, quadratic, cubic terms nonlinear relationship Interaction depression added examine differences Results Depressed exhibited significant greater Specifically, degree decrease increase when slept 2 or more hours less longer usual hours. Non-depressed relatively stable regardless Conclusions nonlinearly lives adults, highlighting both too excessive are adverse well-being. Implementing interventions promote an appropriate help improve among

Language: Английский

Citations

4
Irregular sleep is linked to poorer mental health: A pooled analysis of eight studies DOI
Brett Messman, Joshua F. Wiley, Emily Feldman

et al.

Sleep Health, Journal Year: 2024, Volume and Issue: 10(4), P. 493 - 499

Published: May 3, 2024

Language: Английский

Citations

4
SLEEP CAPITAL. LINKING BRAIN HEALTH TO WELLBEING AND ECONOMIC PRODUCTIVITY ACROSS THE LIFESPAN DOI
Diego A. Golombék, Harris A. Eyre, Ignacio Spiousas

et al.

American Journal of Geriatric Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

4
Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice DOI Creative Commons
André Comiran Tonon, Adile Nexha,

Mariana Mendonça da Silva

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Sleep and biological rhythms are integral to mood regulation across the lifespan, particularly in bipolar disorder (BD), where alterations sleep phase, structure, duration occur all states. These disruptions linked poorer quality of life, heightened suicide risk, impaired cognitive function, increased relapse rates. This review highlights pathophysiology disturbances BD aims consolidate understanding clinical applications these phenomena. It also summarizes evolution assessment methods, including ecological momentary (EMA) digital phenotyping. underscores importance recognizing circadian rhythm involvement regulation, suggesting potential therapeutic targets. Future research directions include elucidating clock gene mechanisms, environmental impacts on rhythms, investigating bidirectional relationship between BD. Standardizing methods addressing privacy concerns related EMA technology phenotyping essential for advancing research. Collaborative efforts crucial enhancing applicability broader implications diagnosis treatment. Overall, significance offers promise improved outcomes through targeted interventions a deeper disorder's underlying mechanisms.

Language: Английский

Citations

4