Current Stem Cell Research & Therapy,
Journal Year:
2023,
Volume and Issue:
19(8), P. 1084 - 1092
Published: Oct. 11, 2023
Abstract::
Wound
infection
often
requires
a
long
period
of
care
and
an
onerous
treatment
process.
Also,
the
rich
environment
makes
wound
ideal
niche
for
microbial
growth.
Stable
structures,
like
biofilm,
drug-resistant
strains
cause
delay
in
healing
process,
which
has
become
one
important
challenges
treatment.
Many
studies
have
focused
on
alternative
methods
to
deal
infections.
One
novel
highly
potential
ways
is
mesenchymal
stromal
cells
(MSCs).
MSCs
are
mesoderm-derived
pluripotent
adult
stem
with
capacity
self-renewal,
multidirectional
differentiation,
immunological
control.
anti-inflammatory
antiapoptotic
effects.
MScs,
as
cells,
differentiate
into
many
mature
cells.
produce
antimicrobial
compounds,
such
peptides
(AMP),
well
secrete
immune
modulators,
two
basic
features
considered
healing.
Despite
advantages,
preserving
structure
activity
most
points
MSCs’
effects
microorganisms
involved
been
confirmed
various
studies.
In
this
review,
we
aimed
discuss
therapeutic
applications
infected
processes.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(4)
Published: May 21, 2024
Mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
are
emerging
as
remarkable
agents
in
the
field
of
immunomodulation
with
vast
potential
for
diagnosing
and
treating
various
diseases,
including
cancer
autoimmune
disorders.
These
tiny
vesicles
laden
a
diverse
cargo
encompassing
proteins,
nucleic
acids,
lipids,
bioactive
molecules,
offering
wealth
biomarkers
therapeutic
options.
MSC-Exos
exhibit
their
immunomodulatory
prowess
by
skillfully
regulating
pattern-recognition
receptors
(PRRs).
They
conduct
symphony
immunological
responses,
modulating
B-cell
activities,
polarizing
macrophages
toward
anti-inflammatory
phenotypes,
fine-tuning
T-cell
activity.
interactions
have
profound
implications
precision
medicine,
immunotherapy,
disease
management,
biomarker
discovery,
regulatory
approvals.
promises
to
usher
new
era
tailored
therapies,
personalized
diagnostics,
more
effective
treatments
medical
conditions.
As
research
advances,
transformative
healthcare
becomes
increasingly
evident.
Composites Part B Engineering,
Journal Year:
2024,
Volume and Issue:
275, P. 111278 - 111278
Published: Feb. 5, 2024
Kidney
disease
is
a
worldwide
public
health
problem,
seriously
threatening
the
quality
of
life
human
beings,
mainly
including
acute
kidney
injury
(AKI),
chronic
(CKD),
and
end-stage
renal
(ESRD),
with
high
mortality
rate.
Current
effective
treatments
include
dialysis
transplants,
but
shortages
donor
organs,
immune
rejection,
other
problems
have
not
been
effectively
addressed.
In
recent
years,
stem
cells
extensively
studied,
due
to
proliferation
multi-directional
differentiation
properties,
shown
great
potential
for
applications
in
field
tissue
regeneration,
which
may
be
an
means
repair
regeneration.
At
same
time,
rapid
development
composite
materials
show
excellent
performance
hemostasis,
anti-inflammatory,
organoids
scaffolds
construction,
expected
further
guide
promoting
this
review,
we
discuss
latest
research
progress
regeneration
from
perspectives
cell
extracellular
vesicle
(EVs)
regulation,
material
combined
used
engineering
kidneys
culture.
Besides,
analyze
summarize
mechanisms
as
well
pathways.
addition,
raise
key
issues
that
currently
constrain
composites
therapy
disease.
Finally,
possible
future
direction
Cancer Reports,
Journal Year:
2024,
Volume and Issue:
7(10)
Published: Oct. 1, 2024
Breast
cancer
is
a
common
form
of
among
women
characterized
by
the
growth
malignant
cells
in
breast
tissue.
The
most
treatments
for
this
condition
include
chemotherapy,
surgical
intervention,
radiation
therapy,
hormone
and
biological
therapy.
primary
issues
associated
with
chemotherapy
therapy
are
their
adverse
events
significant
financial
burden
patients
underdeveloped
countries.
This
highlights
need
to
explore
develop
superior
therapeutic
options
that
less
detrimental
more
economically
efficient.
Plants
provide
an
abundant
supply
innovative
compounds
present
promising
new
avenue
investigating
cancer.
derivations
undergoing
revolution
due
reduced
toxicity,
expediency,
cost-effectiveness,
safety,
simplicity
comparison
conventional
treatment
methods.
Natural
products
considered
candidates
development
anticancer
drugs,
perhaps
diverse
pleiotropic
effects
on
target
events.
plant-derived
limited
while
leaving
healthy
unaffected.
Identification
strong
properties
plant-based
medications
might
be
crucial
steps
Although
bioactive
have
potent
properties,
they
also
drawbacks
resolved
before
application
clinical
trials
improved
approved
drugs.
study
aims
give
comprehensive
information
known
compounds,
including
sources
molecular
mechanisms
actions,
along
opportunities
challenges
therapies.
Aesthetic Surgery Journal Open Forum,
Journal Year:
2023,
Volume and Issue:
5
Published: Jan. 1, 2023
Abstract
The
authors
present
a
rare
case
of
Birt–Hogg–Dubé
(BHD)
syndrome
that
presented
primarily
as
an
aesthetic
case.
Previous
providers
failed
to
accurately
diagnose
BHD,
despite
the
patient’s
history
pneumothoraces.
This
female
patient
complained
numerous
recurrent,
small
skin-colored
growths
on
face
and
neck
patchy
hypopigmentation
from
multiple
treatments
she
had
undergo
for
her
“bumpy
skin.”
She
also
suffered
4
spontaneous
Following
histopathologic
genetic
testing,
was
diagnosed
with
BHD.
Computed
tomography
ultrasound
scans
revealed
cysts
in
both
lungs
angiomyolipoma
kidneys.
undergone
variety
aesthetically
remove
heal
skin
bumps
several
healthcare
providers,
all
whom
misdiagnosed
condition.
Level
Evidence:
5
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 6585 - 6599
Published: Nov. 1, 2023
Multiple
stages
including
hemostasis,
inflammation,
proliferation,
and
remodeling
were
involved
in
the
wound
healing
process.
The
increase
nanomaterials
recent
years
has
extended
scope
of
tools
for
healing;
however,
it
is
still
difficult
to
achieve
four
multistage
procedures
simultaneously.In
this
study,
graphene-spiky
silica
heterostructured
nanoparticles
(GS)
synthesized
procedural
acceleration
nanobridge
effect
GS
was
analyzed
through
adhesion
two
skins,
antibacterial
assessed
Gram-negative
Escherichia
coli
(E.
coli)
Gram-positive
Staphylococcus
aureus
(S.
aureus)
bacteria,
cell
proliferation
migration
investigated
mouse
embryonic
fibroblast
(NIH-3T3)
cells,
vivo
examined
female
BALB/c
mice
with
a
cutting
E.
or
S.
bacteria
infection
on
back.First,
strong
rapid
closure
wounds
because
spiky
architecture
surface
facilitates
promoting
hemostasis
stage.
Second,
graphene
exhibits
antimicrobial
activities
both
chemical
physical
interactions,
especially
under
simulated
sunlight
irradiation.
Third,
plays
an
important
role
scaffolding
function,
together
topographical
GS,
accelerating
maturation
stages.By
periodically
every
stage
healing,
combined
irradiation
could
significantly
accelerate
healing.
With
simple
composition
compact
structure
but
multiple
functions,
strategy
will
be
guideline
development
ideal
wound-healing
nanomaterials.
Current Stem Cell Research & Therapy,
Journal Year:
2023,
Volume and Issue:
19(8), P. 1084 - 1092
Published: Oct. 11, 2023
Abstract::
Wound
infection
often
requires
a
long
period
of
care
and
an
onerous
treatment
process.
Also,
the
rich
environment
makes
wound
ideal
niche
for
microbial
growth.
Stable
structures,
like
biofilm,
drug-resistant
strains
cause
delay
in
healing
process,
which
has
become
one
important
challenges
treatment.
Many
studies
have
focused
on
alternative
methods
to
deal
infections.
One
novel
highly
potential
ways
is
mesenchymal
stromal
cells
(MSCs).
MSCs
are
mesoderm-derived
pluripotent
adult
stem
with
capacity
self-renewal,
multidirectional
differentiation,
immunological
control.
anti-inflammatory
antiapoptotic
effects.
MScs,
as
cells,
differentiate
into
many
mature
cells.
produce
antimicrobial
compounds,
such
peptides
(AMP),
well
secrete
immune
modulators,
two
basic
features
considered
healing.
Despite
advantages,
preserving
structure
activity
most
points
MSCs’
effects
microorganisms
involved
been
confirmed
various
studies.
In
this
review,
we
aimed
discuss
therapeutic
applications
infected
processes.
