Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101436 - 101436
Published: Jan. 5, 2025
Well-designed artificial scaffolds are urgently needed due to the limited self-repair capacity of bone, which hampers effective regeneration in critical defects. Optimal must provide physical guidance recruit cells and immune regulation improve regenerative microenvironment. This study presents a novel scaffold composed dual-sided centripetal microgrooved poly(D,L-lactide-co-caprolactone) (PLCL) film combined with dynamic hydrogel containing prednisolone (PLS)-loaded Prussian blue nanoparticles (PB@PLS). The microgrooves on surface PLCL were imprinted using micropatterned polydimethylsiloxane (PDMS) template. Following aminolysis, was covalently grafted EM-7 peptide via glutaraldehyde. Functional group analysis, morphology hydrophilicity evaluated X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), an optical contact angle measuring instrument, respectively. Bone regeneration-related (e.g., bone marrow mesenchymal stem cells, macrophages, Schwann endothelial cells) cultured films tended align along stripes migrate from periphery toward center region vitro. Subsequently, encapsulated immune-regulating synthesized thiol-modified gelatin Cu2+ presence PB@PLS nanoparticles, demonstrated excellent antioxidant properties. significantly accelerated critical-sized regeneration, as evidenced by increase volume newly formed histological images vivo. innovative approach holds substantial promise for clinical applications broader tissue repair.
Language: Английский
Citations
6
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 10, 2025
Language: Английский
Citations
0
Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Citations
0