Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Dec. 7, 2022
Abstract
Ziwuliuzhu
acupuncture
is
widely
considered
an
effective
treatment
for
insomnia
in
clinics,
but
little
known
about
its
possible
mechanisms.
This
study
investigated
the
therapeutic
effect
of
on
and
regulatory
mechanism
glutamic
acid
(Glu)/γ-aminobutyric
(GABA)-glutamine
(Gln)
metabolic
loop
a
rat
model
insomnia.
Hematoxylin
eosin
staining
was
used
to
observe
pathological
tissue
hypothalamus.
The
levels
neurotransmitters
Glu
GABA
hypothalamus
were
determined
by
high-performance
liquid
chromatography
(HPLC)-mass
spectrometry
(MS)/MS.
Immunohistochemistry
(IHC)
detect
expression
GABAA
receptor
glutamate
decarboxylase
(GAD65/67)
glutamine
synthetase
(GS)
Western
blotting.
Compared
with
group,
groups
showed
decreased
(
p
<
0.001)
0.01),
increased
0.05),
Glu/GABA
ratio.
In
comparison
protein
GAD65
GAD67
0.05)
reduced
GS
0.01).
Glu/GABA-Gln
metabolism
may
be
regulated
produce
sedative
hypnotic
effects,
affecting
synthesis
decomposition,
as
well
restoring
excitatory/inhibitory
balance
between
GABA.
Journal of Sleep Research,
Journal Year:
2023,
Volume and Issue:
32(6)
Published: Nov. 28, 2023
Summary
Progress
in
the
field
of
insomnia
since
2017
necessitated
this
update
European
Insomnia
Guideline.
Recommendations
for
diagnostic
procedure
and
its
comorbidities
are:
clinical
interview
(encompassing
sleep
medical
history);
use
questionnaires
diaries
(and
physical
examination
additional
measures
where
indicated)
(A).
Actigraphy
is
not
recommended
routine
evaluation
(C),
but
may
be
useful
differential‐diagnostic
purposes
Polysomnography
should
used
to
evaluate
other
disorders
if
suspected
(i.e.
periodic
limb
movement
disorder,
sleep‐related
breathing
disorders,
etc.),
treatment‐resistant
(A)
indications
(B).
Cognitive‐behavioural
therapy
as
first‐line
treatment
chronic
adults
any
age
(including
patients
with
comorbidities),
either
applied
in‐person
or
digitally
When
cognitive‐behavioural
sufficiently
effective,
a
pharmacological
intervention
can
offered
Benzodiazepines
(A),
benzodiazepine
receptor
agonists
daridorexant
low‐dose
sedating
antidepressants
(B)
short‐term
(≤
4
weeks).
Longer‐term
these
substances
initiated
some
cases,
considering
advantages
disadvantages
Orexin
antagonists
periods
up
3
months
longer
cases
Prolonged‐release
melatonin
≥
55
years
Antihistaminergic
drugs,
antipsychotics,
fast‐release
melatonin,
ramelteon
phytotherapeutics
are
Light
exercise
interventions
adjunct
therapies
Cleveland Clinic Journal of Medicine,
Journal Year:
2025,
Volume and Issue:
92(1), P. 43 - 50
Published: Jan. 1, 2025
Insomnia
is
a
common
and
challenging
complaint
in
older
adults
(>
65
years)
because
of
age-related
alterations
sleep
physiology.
Cognitive
behavioral
therapy
for
insomnia
the
gold
standard
treatment
young
as
well
patients.
Both
clinicians
patients
often
prefer
simplicity
medication,
but
risks
associated
with
some
hypnotics
increase
age.
Pharmacologic
options
include
low-dose
doxepin,
melatonin,
ramelteon,
dual
orexin
receptor
antagonists.
A
well-informed
clinician
can
help
navigate
benefits
both
pharmacologic
options.
Journal of Clinical Nursing,
Journal Year:
2024,
Volume and Issue:
33(5), P. 1948 - 1957
Published: March 1, 2024
Abstract
Aims
and
Objectives
To
compare
the
effectiveness
of
non‐pharmacological
interventions
in
enhancing
sleep
quality
older
people.
Background
Sleep
problems
adults
have
become
increasingly
prominent.
not
only
affect
health
life
people,
but
also
range
chronic
diseases
caused
by
impose
a
huge
burden
on
social
services
care.
Non‐pharmacological
are
an
effective
alternative
to
pharmacological
therapies,
it
is
unclear
which
therapies
most
adults.
Design
A
systematic
review
network
meta‐analysis
based
PRISMA‐NMA.
Methods
total
seven
databases
were
searched
from
establishment
database
March
2023.
After
literature
screening
data
extraction,
Cochrane
Bias
assessment
tool
2.0
version
randomised
controlled
trials
(RCTs)
was
used
evaluate
quality.
performed
relative
efficacy
Results
71
RCTs
involving
nine
included.
The
results
showed
that
joint
intervention
may
be
enhance
Conclusion
This
study
confirms
can
improve
use
promoted
healthcare
professionals
future
thus
physical
mental
Relevance
Clinical
Practice
evidence
suggests
effective.
Therefore,
future,
combination
could
maximise
their
improving
people
promoting
healthy
aging.
No
Patient
or
Public
Contribution
patient
public
contribution
applicable
this
study.
JAMA Network Open,
Journal Year:
2024,
Volume and Issue:
7(4), P. e246865 - e246865
Published: April 17, 2024
Although
insomnia
guidelines
recommend
the
use
of
several
individual
hypnotics,
most
useful
hypnotic
for
treating
in
a
clinical
setting
remains
unclear.
JMIR Mental Health,
Journal Year:
2024,
Volume and Issue:
11, P. e58217 - e58217
Published: June 15, 2024
Insomnia
is
a
prevalent
condition
with
significant
health,
societal,
and
economic
impacts.
Cognitive
behavioral
therapy
for
insomnia
(CBTI)
recommended
as
the
first-line
treatment.
With
limited
accessibility
to
in-person-delivered
CBTI
(ipCBTI),
electronically
delivered
eHealth
(eCBTI),
ranging
from
telephone-
videoconference-delivered
interventions
fully
automated
web-based
programs
mobile
apps,
has
emerged
an
alternative.
However,
relative
efficacy
of
eCBTI
compared
ipCBTI
not
been
conclusively
determined.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 9, 2025
Abstract
Background
Digital
Health
Interventions
(DHIs)
for
promoting
sleep,
treating,
and
preventing
insomnia
are
a
scalable,
accessible,
resource-efficient
alternative
to
traditional
interventions.
Though
sleep
problems
common
in
adolescents,
limited
research
has
focused
on
this
age
group.
The
appropriateness
of
DHIs
promotion
or
treatment
adolescent
populations,
along
with
the
active
components
associated
effective
interventions,
needs
be
assessed.
This
review
evaluated
among
adolescents
distilled
their
components.
Methods
Randomized
Controlled
Trials
(RCTs)
were
selected
from
OVID
(Medline),
CINAHL,
Web
Science,
SCOPUS,
PsycINFO,
Embase
databases
inception
June
30,
2023,
updated
May
2024.
Adolescence
was
defined
as
phase
life
stretching
between
childhood
adulthood
(10
24
years
old).
Results
Nine
studies
identified,
involving
9238
participants,
whom
n
=
4498
(47.8%)
females,
12
old
(Mean:
15.6
years).
Eight
digital
cognitive
behavioural
therapy
dCBT-I,
one
study
holistic
lifestyle
DHI.
Most
delivered
DHI
unguided
using
automatic
messages
(n
4;
44.4%).
dCBT-I
demonstrated
medium
positive
effect
5;
g
=-
0.64,
p
0.01)
subjective
quality
immediately
after
treatment.
suggested
that
restructuring,
mindfulness,
stimulus
control
optional
restriction
technique.
Conclusions
findings
suggest
could
beneficial
comorbid
mental
health
adolescents.
Possible
component
interventions
may
include
diary,
part
education,
control.
Sleep Science,
Journal Year:
2023,
Volume and Issue:
16(S 02), P. 507 - 549
Published: Oct. 1, 2023
Abstract
Chronic
insomnia
disorder
(simplified
in
this
document
as
insomnia)
is
an
increasingly
common
clinical
condition
society
and
a
frequent
complaint
at
the
offices
of
different
areas
health
practice
(particularly
Medicine
Psychology).
This
scenario
has
been
accompanied
by
significant
evolution
treatment,
well
challenges
approaching
patients
appropriately
way.
guideline,
coordinated
Brazilian
Sleep
Association
counting
on
active
participation
various
specialists
area,
encompasses
update
diagnosis
treatment
adults.
To
end,
it
followed
structured
methodology.
Topics
interest
related
to
were
written
based
theoretical
framework,
evidence
literature,
professional
experience.
As
for
topics
insomnia,
series
questions
developed
PICO
acronym
(P
–
Patient,
problem,
or
population;
I
Intervention;
C
Comparison,
control,
comparator;
O
Outcome).
The
work
groups
defined
eligible
options
within
each
these
parameters.
Regarding
pharmacological
interventions,
only
ones
currently
available
Brazil
possibly
becoming
upcoming
years
considered
eligible.
Systematic
reviews
conducted
help
prepare
texts
define
level
intervention.
final
result
objective
practical
providing
recommendations
with
best
scientific
support
professionals
involved
management
insomnia.
