Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application DOI Creative Commons

Kaixin Guo,

Yan Lü,

Xiuping Wang

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 23, 2024

As medical research advances and technology rapidly develops, auricular acupuncture has emerged as a point of growing interest. This paper delves into the intricate anatomy points, their significance therapeutic principles in traditional Chinese medicine (TCM), underlying mechanisms contemporary medicine. The aim is to delve deeply this ancient mysterious tradition, unveiling its multi-layered mysteries field neurostimulation. anatomical structure points complex delicate, unique neurovascular network grants them special status neurostimulation therapy. Through exploration these features, we not only comprehend position TCM theory but also provide profound foundation for modern applications. systematic review, synthesize insights from research. Building upon classical theoretical foundations, focus on encompasses neuroregulation, pain management, psychological wellbeing, metabolic disorders, immune modulation. latest clinical confirms efficacy stimulation alleviating symptoms modulating diseases at endocrine level underscores potential role regulating patients’ wellbeing. article aims promote comprehensive understanding by demonstrating diverse applications providing substantial evidence support broader adoption practice.

Language: Английский

Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: results of European neuropsychopharmacology and sleep expert’s consensus group DOI
Laura Palagini,

Roberto Brugnoli,

Bernardo M Dell' Osso

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 128, P. 117 - 126

Published: Jan. 31, 2025

Language: Английский

Citations

2
Drug development in psychiatry: 50 years of failure and how to resuscitate it DOI
David Nutt

The Lancet Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Mirtazapine for chronic insomnia in older adults: a randomised double-blind placebo-controlled trial—the MIRAGE study DOI
Patrick Viet-Quoc Nguyen, Thien Thanh Dang‐Vu, Geneviève Forest

et al.

Age and Ageing, Journal Year: 2025, Volume and Issue: 54(3)

Published: March 1, 2025

Mirtazapine promotes sleep by blocking serotonin and histaminergic receptors is often used off-label to treat chronic insomnia. However, its efficacy remains be demonstrated in a clinical trial. The MIRAGE study aims determine the safety of mirtazapine older patients with This was double-blind, randomised, placebo-controlled trial geriatric outpatient clinic teaching hospital. Adults aged 65 years insomnia were included. Sixty participants randomised 1:1 ratio receive 7.5 mg or matching placebo for 28 days. primary endpoint mean change Insomnia Severity Index (ISI) score from baseline days post-treatment. endpoints included any adverse events reported during all leading premature discontinuation. superior on outcome measure, subjective wake after onset, total time efficiency. After days, ISI significantly greater group (-6.5 [95%CI; -8.3 -4.8]) compared (-2.9 -4.4 -1.4]), p-value 0.003. No participant experienced severe events. A 6 1 discontinued their treatment due reduces symptoms people. use may limited mild but clinically relevant (clinicaltrials.gov NCT05247697). first adults Our findings show that 28-day mirtazapine, placebo, severity, as measured Index. Despite current lack robust evidence, widely prescribed clinicians Publishing our will facilitate broad dissemination this critical information, helping more effectively patients.

Language: Английский

Citations

2
Insomnia, anxiety and related disorders: a systematic review on clinical and therapeutic perspective with potential mechanisms underlying their complex link DOI Creative Commons
Laura Palagini, Mario Miniati, Valerio Caruso

et al.

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 103936 - 103936

Published: Jan. 1, 2024

Anxiety and anxiety-related disorders are the most common mental disturbances, with dysregulation in emotions cognition as central features. Since function of sleep regulating is quintessential stress response inflammation, disturbances may be ideal modifiable factors anxiety related disorders. Accordingly, aim review was to systematically association between insomnia symptoms A systematic search has been conducted, 93 papers have selected for General Disorder, Panic Disorders, Social Separation anxiety, Obsessive Compulsive Disorder Post Traumatic Stress according PRISMA. This represents a comprehensive overview clinical therapeutic approaches framework discussion potential mechanisms underlying their complex link.

Language: Английский

Citations

12
Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression? DOI Creative Commons
Dieter Riemann, Raphael J. Dressle, Fee Benz

et al.

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Summary The world‐wide prevalence of insomnia disorder reaches up to 10% the adult population. Women are more often afflicted than men, and is a risk factor for somatic mental illness, especially depression anxiety disorders. Persistent hyperarousals at cognitive, emotional, cortical and/or physiological levels central most theories regarding pathophysiology insomnia. Of defining features disorder, discrepancy between minor objective polysomnographic alterations sleep continuity substantive subjective impairment in remains enigmatic. Microstructural alterations, rapid eye movement (“rapid instability”), might explain this mismatch findings. As represents highly aroused brain state during sleep, it be particularly prone fragmentation individuals with persistent hyperarousal. In consequence, mentation may toned as conscious‐like wake experience, reflecting pre‐sleep concerns. It suggested that instability involved measures disorder. Furthermore, has been linked previous works emotional processing, could play role close association depressive

Language: Английский

Citations

9
Cognitive Behavioral Therapy for Insomnia across the Spectrum of Alcohol Use Disorder: A Systematic Review and Meta-Analysis DOI Creative Commons
Cagdas Türkmen, Carlotta L. Schneider, Wolfgang Viechtbauer

et al.

Sleep Medicine Reviews, Journal Year: 2025, Volume and Issue: 80, P. 102049 - 102049

Published: Jan. 11, 2025

Language: Английский

Citations

1
Systematic Review and Meta-Analysis: The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder DOI Creative Commons
Cagdas Türkmen,

Noah Machunze,

Alycia M Lee

et al.

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

To examine the association between newer generation antidepressants and insomnia as an adverse event (AE) in treatment of children adolescents with major depressive disorder (MDD). A systematic search was performed databases (inception to August 31st, 2023) retrieve double-blind, placebo-controlled, randomized controlled trials (RCTs) evaluating safety 19 acute (initial 6 12 weeks) aged ≤ 18 years MDD (primary analyses). RCTs anxiety disorders obsessive-compulsive (OCD) were retrieved from a recent meta-analysis included complementary analyses. mixed-effects logistic regression model used compare frequency antidepressant relative placebo group. Risk bias evaluated using Cochrane Bias 2 tool. In total, 20 (N = 5,357) 8 OCD 1,271) selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine (SNRIs) included. MDD, associated modest increase odds compared (OR 1.65, 95% CI 1.21-2.27, p 0.002), no significant difference SSRIs SNRIs. The showed low risk minor concerns for assessment insomnia. treatment-emergent significantly lower 1.62; 1.21-2.15) 2.89; 1.83-4.57) (p 0.03). Among individual evidence ≥ 3 studies, sertraline had highest OR (3.45; 1.91-6.24), while duloxetine lowest (1.38; 0.79 - 2.43). Children are at modestly increased experiencing during first weeks Antidepressant- disorder-specific variability may be relevant consider clinical decision-making.

Language: Английский

Citations

1
Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms DOI Open Access

Jon L. Pertab,

Tricia L. Merkley,

Holly R. Winiarski

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33

Published: Jan. 17, 2025

A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules

Language: Английский

Citations

1
Web-based cognitive-behavioral therapy for insomnia in cancer survivors: the OncoSleep randomized trial DOI Creative Commons
Maria Inês Clara, Annemieke van Straten, Josée Savard

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 129, P. 67 - 74

Published: Feb. 19, 2025

Insomnia is highly prevalent among cancer survivors and can have serious implications if inadequately treated. Cognitive-behavioral therapy for (CBT-I) recommended as the first-line treatment insomnia but rarely available to survivors. We tested effectiveness of a web-based CBT-I program, OncoSleep, in Cancer with (n = 154) were randomly assigned (1:1) digital (6 weekly self-guided modules plus online clinician support) or waitlist control group. Patient-reported outcome measures severity (primary outcome), daytime functioning, sleep diaries administered at baseline post-treatment (8 weeks). Intention-to-treat analyses performed using mixed-effects models. Statistical tests two-sided. The group reported an average 11.0-point reduction Severity index (ISI), compared 1.4-point (p<.001). Statistically significant group-by-time interactions observed: produced significant, large effects improvements (d -2.56), cognitive functioning 0.95), physical 1.24) psychological quality life 0.80), fatigue -1.35). Small-to-large effect sizes found reductions anxiety -0.77), depression -0.71), pain -0.40). Change mediated on outcomes. Web-based support appears be effective survivors, offering meaningful benefits comorbid symptoms life. Further studies active comparisons longer follow-up periods are needed confirm these findings. Digital could integrated into rehabilitation programs reduce burden insomnia. [ClinicalTrials.gov: NCT04898855].

Language: Английский

Citations

1
Barriers and Facilitators of Sleep Restriction Therapy in Internet‐Delivered CBT‐I: A Qualitative Content Analysis and the Development of a Treatment Path Model DOI Creative Commons
Laura Simon, Lisa Steinmetz, N. M. Berghoff

et al.

Journal of Sleep Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

ABSTRACT Sleep Restriction Therapy (SRT) is a core component of cognitive behavioural therapy for insomnia (CBT‐I). Yet, adherence to SRT can be major challenge patients. As this evident in conventional face‐to‐face therapy, it raises the question internet‐delivered therapy. This qualitative study investigates CBT‐I and aims identify candidate variables that guide treatment decisions. Participants diagnosed with who participated an as part stepped‐care model were interviewed. Data from interviews 23 participants included study. A content analysis was employed. Hindering facilitating individual, intervention‐related, e‐coaching‐related factors examined. Moreover, consequences (e.g., negative effects attrition) Eleven consistently implemented SRT, two rejected beginning, eight discontinued, showed inconsistent adherence. Docility, low levels frustration tolerance, previous experiences emerged hindering individual factors. In contrast, high level insomnia‐related burden, social support, perceived fit program, being satisfied therapeutic guidance appeared foster Based on results study, path introduced, postulating predictors indication within docility SRT), engagement commitment support), potential process monitoring satisfaction need guidance).

Language: Английский

Citations

1