ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
N
‐heterocyclic
carbenes
(NHCs)
are
a
class
of
compounds
known
for
their
biological
activities
which
the
presence
therapeutic
metal
can
enhance.
The
discovery
cisplatin
as
an
effective
anticancer
metallodrug
led
to
research
into
other
metal‐based
drugs,
not
only
but
applications
such
antimicrobial,
antirheumatic,
and
antidiabetic.
Since
metallic
silver
has
been
have
antimicrobial
efficacy,
Ag(I)‐NHC
complexes
developed
enhance
efficacy
both
NHC.
In
this
study,
we
present
current
review
activity
several
azolium
salts
corresponding
NHC
coinage
metals
(Ag,
Au,
Cu
in
order
importance).
We
fully
analyzed
discussed
efficacies
when
benchmarked
against
commercially
available
drugs.
Also
highlighted
where
studies
based
on
structure‐activity
relationships,
included
variations
wingtip
‐substituents
ligands
changes
type,
number
oxidation
state
ions
complex.
Brain and Behavior,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: Feb. 1, 2025
ABSTRACT
Background
Sleep
disturbances
have
become
increasingly
prevalent
in
modern
society.
Research
suggests
that
a
deficiency
magnesium
(Mg)
may
contribute
to
sleep
disturbances.
This
study
aims
investigate
the
association
between
daily
Mg
intake
and
self‐reported
duration
disorders
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
The
dataset
includes
participants
five
cycles
(2009–2018)
of
NHANES.
associations
are
analyzed
weighted
logistic
regression.
Results
Baseline
characteristics
21,840
were
analyzed.
was
independently
associated
with
(OR
=
1.07,
95%
CI
(1.01–1.14),
p
0.024).
Higher
quartiles
food
normal
duration.
However,
did
not
differ
those
without
0.96,
(0.90–1.03),
0.238).
Among
3923
supplementation
data,
no
significant
differences
found
top
bottom
50%
supplementary
groups
regarding
or
disorders.
Conclusions
Dietary
is
short
but
either
npj Women s Health,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: Feb. 28, 2025
Abstract
The
circadian
clock
plays
a
crucial
role
in
regulating
the
timing
of
numerous
physiological
processes.
Its
dysregulation
has
severe
implications
for
organism’s
homeostasis
and
is
among
main
characteristics
aging.
As
women
age
transition
through
menopause,
disruptions
rhythms
may
occur,
leading
to
symptoms
such
as
insomnia,
mood
changes,
or
altered
energy
levels.
In
this
prospective
non-randomized
cohort
study,
we
seek
characterize
better
understand
alterations
across
various
stages
their
reproductive
cycle,
both
with
without
daily
routine
(e.g.,
specific
diet,
light
exposure).
Understanding
intricate
relationship
between
female
health
during
aging
process
essential
developing
targeted
interventions
mitigate
promote
overall
well-being
menopausal
women.
Findings
from
study
will
be
used
devise
tailored
rhythm
assessments
women,
facilitating
alleviation
menopause-related
promoting
healthy
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
N
‐heterocyclic
carbenes
(NHCs)
are
a
class
of
compounds
known
for
their
biological
activities
which
the
presence
therapeutic
metal
can
enhance.
The
discovery
cisplatin
as
an
effective
anticancer
metallodrug
led
to
research
into
other
metal‐based
drugs,
not
only
but
applications
such
antimicrobial,
antirheumatic,
and
antidiabetic.
Since
metallic
silver
has
been
have
antimicrobial
efficacy,
Ag(I)‐NHC
complexes
developed
enhance
efficacy
both
NHC.
In
this
study,
we
present
current
review
activity
several
azolium
salts
corresponding
NHC
coinage
metals
(Ag,
Au,
Cu
in
order
importance).
We
fully
analyzed
discussed
efficacies
when
benchmarked
against
commercially
available
drugs.
Also
highlighted
where
studies
based
on
structure‐activity
relationships,
included
variations
wingtip
‐substituents
ligands
changes
type,
number
oxidation
state
ions
complex.
