Ultrasensitive Detection of COVID-19 Causative Virus (SARS-CoV-2) Spike Protein Using Laser Induced Graphene Field-Effect Transistor DOI Creative Commons
Tianrui Cui, Yancong Qiao, Jianwei Gao

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(22), P. 6947 - 6947

Published: Nov. 17, 2021

COVID-19 is a highly contagious human infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and war with virus still underway. Since no specific drugs have been made available yet there an imbalance between supply demand for vaccines, early diagnosis isolation are essential to control outbreak. Current nucleic acid testing methods require high sample quality laboratory conditions, which cannot meet flexible applications. Here, we report laser-induced graphene field-effect transistor (LIG-FET) detecting SARS-CoV-2. The FET was manufactured different reduction degree LIG, oyster reef-like porous channel enrich binding point protein sensing area. After immobilizing antibodies in channel, can detect SARS-CoV-2 spike 15 min at concentration of 1 pg/mL phosphate-buffered saline (PBS) ng/mL serum. In addition, sensor shows great specificity Our sensors realize fast production rapid testing, as each LIG-FET be fabricated laser platform seconds. It first time that LIG has realized without any pretreatment or labeling, paves way low-cost detection COVID-19.

Language: Английский

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization DOI
Changhao Dai, Yunqi Liu, Dacheng Wei

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(11), P. 10319 - 10392

Published: April 12, 2022

The evolutionary success in information technology has been sustained by the rapid growth of sensor technology. Recently, advances have promoted ambitious requirement to build intelligent systems that can be controlled external stimuli along with independent operation, adaptivity, and low energy expenditure. Among various sensing techniques, field-effect transistors (FETs) channels made two-dimensional (2D) materials attract increasing attention for advantages such as label-free detection, fast response, easy capability integration. With atomic thickness, 2D restrict carrier flow within material surface expose it directly environment, leading efficient signal acquisition conversion. This review summarizes latest 2D-materials-based FET (2D FET) sensors a comprehensive manner contains material, operating principles, fabrication technologies, proof-of-concept applications, prototypes. First, brief description background fundamentals is provided. subsequent contents summarize physical, chemical, biological their applications. Then, we highlight challenges commercialization discuss corresponding solution techniques. following section presents systematic survey recent progress developing commercial Lastly, long-standing efforts prospective future development FET-based toward commercialization.

Language: Английский

Citations

178
Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials DOI
E. Celeste Welch, Jessica M. Powell, Tobias B. Clevinger

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(44)

Published: July 28, 2021

Abstract Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering resulted increasing use of nanostructures biosensors. Various types 0D, 1D, 2D, and 3D been used to improve biosensor sensitivity, selectivity, limit detection, time result, among other metrics. These integrated into electrochemical, optical, biosensors this purpose. Here, the most recent advances nanostructured are described. This includes a discussion nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, complex hierarchical structures their advantages applications Clinical these nanobiosensors also highlighted along with future directions diagnostics.

Language: Английский

Citations

136
Recent advances in chemical vapour deposition techniques for graphene-based nanoarchitectures: From synthesis to contemporary applications DOI
Mohamed Bahri, Shushay Hagos Gebre, Mohamed Amin Elaguech

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214910 - 214910

Published: Oct. 31, 2022

Language: Английский

Citations

101
Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles DOI
Jinbo Pang, Songang Peng, Chongyang Hou

et al.

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(2), P. 482 - 514

Published: Jan. 19, 2023

Graphene remains of great interest in biomedical applications because biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future recovery patients. In this review, we update most recent progress graphene based sensors for mimicking such as retina image sensors, eardrums, gas chemical tactile sensors. The brain-like processors are discussed on conventional transistors well memristor related neuromorphic computing. brain–machine interface is introduced providing single pathway. Besides, muscles summarized means actuators order react physical world. Future opportunities remain elevating performances human-like their clinical applications.

Language: Английский

Citations

52
Gold nanoparticles (AuNPs): A versatile material for biosensor application DOI Creative Commons
Meiyanti Ratna Kumalasari, Rokiy Alfanaar, Agustina Sus Andreani

et al.

Talanta Open, Journal Year: 2024, Volume and Issue: 9, P. 100327 - 100327

Published: May 16, 2024

Gold nanoparticles (AuNPs) have become the focus of rapid research due to their unique optical and electronic properties. There has been a noticeable increase in papers relating AuNPs, with over 71,000 publications between 2019 2024. AuNPs possess exceptional stability, low resistance, high conductivity, extensive light interaction, making them well-suited for biological sensing applications. This literature study begins by examining different approaches synthesizing including chemical, physical, methods, before exploring use as biosensors. A comprehensive examination various detection localized surface plasmon resonance (LSPR), luminescence, surface-enhanced Raman scattering (SERS), (SPR), electrochemical properties, is facilitated through an exploration fundamental principles classification We primarily on using medical diagnostics, highlighting current advancements disease AuNPs-based biosensors conditions like COVID-19, dengue fever, diabetes. The review emphasizes achievements synthesis bright prospects biocompatible efficient biosensor

Language: Английский

Citations

48
Challenges for Field-Effect-Transistor-Based Graphene Biosensors DOI Open Access
Takao Ono, Satoshi Okuda, Shota Ushiba

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 333 - 333

Published: Jan. 9, 2024

Owing to its outstanding physical properties, graphene has attracted attention as a promising biosensor material. Field-effect-transistor (FET)-based biosensors are particularly because of their high sensitivity that is achieved through the carrier mobility graphene. However, graphene-FET have not yet reached widespread practical applications owing several problems. In this review, authors focus on and discuss advantages, challenges development, solutions challenges. The problem Debye screening, in which surface charges detection target shielded undetectable, can be solved by using small-molecule receptors deformations enzyme reaction products. To address complexity sample components mechanisms biosensors, outline measures against nonspecific adsorption remaining problems related mechanism itself. also introduce solution with molecular species reach sensor surfaces limited. Finally, present multifaceted approaches provide much information corroborate results electrical measurements. introduced bring us closer realization stable utilizing superior characteristics

Language: Английский

Citations

21
Recent Advances in Graphene Field‐Effect Transistor Toward Biological Detection DOI
Mingyuan Sun, Congcong Zhang, Shan Lu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 22, 2024

Abstract Recently, field‐effect transistors (FETs) have emerged as a novel type of multiparameter, high‐performance, highly integrated platform for biochemical detection, leveraging their classical three‐terminal structure, working principles, and fabrication methods. Notably, graphene materials, known exceptional electrical optical properties well biocompatibility, serve fundamental component these devices, further enhancing advantages in biological detection. This review places special emphasis on recent advancements transistor (GFET)‐based biosensors focuses four main areas: i) the basic concepts FETs specific GFETs; ii) various state‐of‐the‐art approaches to enhance performance GFET‐based terms operating principles “3S”—stability, sensitivity, specificity; iii) multiplexed detection strategies biosensors; iv) current challenges future perspectives field biosensors. It is hoped that this article can profoundly elucidate development GFET inspire broader audience.

Language: Английский

Citations

20
2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices DOI Creative Commons
Sobia Nisar, Ghulam Dastgeer, Zafar Muhammad Shazad

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 18, 2024

Since two-dimensionalal (2D) materials have distinct chemical and physical properties, they are widely used in various sectors of modern technologies. In the domain diagnostic biodevices, particularly for point-of-care (PoC) biomedical diagnostics, 2D-based field-effect transistor biosensors (bio-FETs) demonstrate substantial potential. Here, this review article, operational mechanisms detection capabilities biosensing devices utilizing graphene, transition metal dichalcogenides (TMDCs), black phosphorus, other 2D addressed detail. The incorporation these into FET-based offers significant advantages, including low limits (LOD), real-time monitoring, label-free diagnosis, exceptional selectivity. also highlights diverse applications biosensors, ranging from conventional to wearable devices, underscoring versatility material-based FET devices. Additionally, provides a comprehensive assessment limitations challenges faced by along with insights future prospects advancements. Notably, detailed comparison is tabulated platforms their working mechanisms. Ultimately, aims stimulate further research innovation field while educating scientific community about latest advancements materials-based biosensors.

Language: Английский

Citations

19
Graphene for Biosensing Applications in Point-of-Care Testing DOI
Ioannis Prattis,

Ernestine Hui,

Patrik Gubeljak

et al.

Trends in biotechnology, Journal Year: 2021, Volume and Issue: 39(10), P. 1065 - 1077

Published: Feb. 9, 2021

Language: Английский

Citations

78
Carbon-Dot-Enhanced Graphene Field-Effect Transistors for Ultrasensitive Detection of Exosomes DOI

Sami Ramadan,

Richard Lobo,

Yuanzhou Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(7), P. 7854 - 7864

Published: Feb. 9, 2021

Graphene field-effect transistors (GFETs) are suitable building blocks for high-performance electrical biosensors, because graphene inherently exhibits a strong response to charged biomolecules on its surface. However, achieving ultralow limit-of-detection (LoD) is limited by sensor time and screening effect. Herein, we demonstrate that the detection limit of GFET biosensors can be improved significantly decorating uncovered area with carbon dots (CDs). The developed CDs-GFET used exosome exhibited higher sensitivity, faster response, three orders magnitude improvements in LoD compared nondecorated biosensors. A down 100 particles/μL was achieved capability further improvements. results were supported atomic force microscopy (AFM) fluorescent measurements. will aid development an ultrahigh sensitivity biosensing platform based rapid early diagnosis diseases.

Language: Английский

Citations

77