A novel fluorescent sensor for imaging of viscosity and ClO− in plant cells and zebrafish DOI

Siyi Shen,

Yuehua Yuan,

Yuzhen Wang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126162 - 126162

Published: April 1, 2025

Language: Английский

Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy DOI
Hui Li, Yujun Kim,

Hyoje Jung

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

Citations

220
A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish DOI Creative Commons

Si-Lin Xu,

Fangfang Guo,

Zhi-Hong Xu

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 383, P. 133510 - 133510

Published: Feb. 13, 2023

A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric response toward hypochlorite (ClO-) with the LOD (0.082 μM), and "turn-on" to viscosity changes. Due low cytotoxicity good biocompatibility, used monitor hypochlorous acid in mitochondria of living cells zebrafish.

Language: Английский

Citations

88
Fluorescent Probes as a Tool in Diagnostic and Drug Delivery Systems DOI Creative Commons
Nikolai I. Georgiev, Ventsislav V. Bakov, Kameliya Anichina

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 381 - 381

Published: March 1, 2023

Over the last few years, development of fluorescent probes has received considerable attention. Fluorescence signaling allows noninvasive and harmless real-time imaging with great spectral resolution in living objects, which is extremely useful for modern biomedical applications. This review presents basic photophysical principles strategies rational design as visualization agents medical diagnosis drug delivery systems. Common phenomena, such Intramolecular Charge Transfer (ICT), Twisted (TICT), Photoinduced Electron (PET), Excited-State Proton (ESIPT), Fluorescent Resonance Energy (FRET), Aggregation-Induced Emission (AIE), are described platforms fluorescence sensing vivo vitro. The presented examples focused on pH, biologically important cations anions, reactive oxygen species (ROS), viscosity, biomolecules, enzymes that find application diagnostic purposes. general regarding molecular logic devices fluorescence-drug conjugates theranostic systems discussed. work could be help researchers working field compounds, gates, delivery.

Language: Английский

Citations

49
An ultra-sensitive ESIPT fluorescent probe for distinguishing cancerous cells and diagnosing APAP-induced liver injury via HClO fluctuation DOI
Miao Chen,

Shuiling Lin,

Xiaoyu Chen

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 386, P. 133749 - 133749

Published: March 30, 2023

Language: Английский

Citations

33
Tuning the Cellular Uptake and Retention of Rhodamine Dyes by Molecular Engineering for High‐Contrast Imaging of Cancer Cells DOI
Gangwei Jiang,

Xiaofeng Lou,

Shan Zuo

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: March 1, 2023

Probes allowing high-contrast discrimination of cancer cells and effective retention are powerful tools for the early diagnosis treatment cancer. However, conventional small-molecule probes often show limited performance in both aspects. Herein, we report an ingenious molecular engineering strategy tuning cellular uptake rhodamine dyes. Introduction polar aminoethyl leads to increased brightness reduced dyes, this change can be reversed by amino acetylation. Moreover, these modifications allow take up more dyes than normal (16-fold) through active transport. Specifically, further improve signal contrast (56-fold) between constructing activatable confirm that released fluorophore remain with extended time, enabling long-term specific tumor imaging.

Language: Английский

Citations

28
Recent progress and outlooks in rhodamine-based fluorescent probes for detection and imaging of reactive oxygen, nitrogen, and sulfur species DOI
Ping Yang,

A-Ling Tang,

Shuai Tan

et al.

Talanta, Journal Year: 2024, Volume and Issue: 274, P. 126004 - 126004

Published: April 1, 2024

Language: Английский

Citations

13
A triphenylamine-based fluorescence probe for detection of hypochlorite in mitochondria DOI

Guan-Hua Yu,

Haoran Hu,

Ruibin Liu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 299, P. 122830 - 122830

Published: May 10, 2023

Language: Английский

Citations

22
A novel fluorescent probe based on carbazole-thiophene for the recognition of hypochlorite and its applications DOI

Yana Tao,

Yu Jin,

Yuanyuan Cui

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 310, P. 123912 - 123912

Published: Jan. 22, 2024

Language: Английский

Citations

7
A “turn-on” fluorescence probe based on a novel hypochlorous acid-induced cyclization response mechanism, and its applications in real water samples and bioimaging in vitro and in vivo DOI
Qian Han,

Zhuye Shang,

Tingwei Zhang

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139361 - 139361

Published: July 22, 2024

Language: Английский

Citations

6
A new-type HOCl-activatable fluorescent probe and its applications in water environment and biosystems DOI Open Access
Kun Wang, Yilin Liu, Caiyun Liu

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 839, P. 156164 - 156164

Published: May 21, 2022

Language: Английский

Citations

28