A novel fluorescent sensor for imaging of viscosity and ClO− in plant cells and zebrafish DOI

Siyi Shen,

Yuehua Yuan,

Yuzhen Wang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126162 - 126162

Published: April 1, 2025

Language: Английский

A ratiometric near‐infrared fluorescent probe for the detection and monitoring of hypochlorous acid in rheumatoid arthritis model and real water samples DOI Creative Commons

Zhuye Shang,

Xinyi Yang, Qingtao Meng

et al.

Smart Molecules, Journal Year: 2023, Volume and Issue: 1(2)

Published: March 21, 2023

Abstract Recent studies revealed that the increased level of hypochlorous acid (HOCl) may be deemed to one signs chronic inflammatory joint disease. Accordingly, development effective methods for rapid and accurate detection or monitoring HOCl in vivo is great significance further understanding role rheumatoid arthritis (RA). Herein, a ratiometric near‐infrared (NIR) fluorescent probe ( PTA ) was reported HOCl. In presence HOCl, electron‐rich S atom C=C double bond were oxidized sequence, resulting significant hypochromatic shift decline absorption spectra. Simultaneously, intramolecular charge transfer (ICT) process inhibited, causing intrinsic fluorescence emission from 680 550 nm. ‐based test paper strips successfully prepared applied determinate actual water samples by “naked eye” colorimetric method. features NIR emission, large Stokes (200 nm), low cytotoxicity, high sensitivity (33.9 nM), short response time (45 s), which enable it utilized imaging endogenous exogenous living zebrafish mice. More importantly, shows remarkable effectiveness HOCl‐mediated treatment RA. Consequently, provides new approach understand RA evaluate drug efficiency

Language: Английский

Citations

15
Bifunctional near-infrared fluorescent probe for the selective detection of bisulfite and hypochlorous acid in food, water samples and in vivo DOI

Zhuye Shang,

Qingtao Meng, Run Zhang

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1279, P. 341783 - 341783

Published: Sept. 5, 2023

Language: Английский

Citations

14
A hydrazone dual-functional fluorescent probe based on carbazole and coumarin groups for the detection of Cu2+ and ClO−: Application in live cell imaging and actual water samples DOI
Li Liu,

Changqing Guo,

Qisheng Zhang

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2021, Volume and Issue: 423, P. 113593 - 113593

Published: Oct. 12, 2021

Language: Английский

Citations

31
Novel Mitochondria-Targeting and Naphthalimide-based Fluorescent Probe for Detecting HClO in Living Cells DOI Creative Commons

Junhong Xu,

Chunyan Wang, Qiujuan Ma

et al.

ACS Omega, Journal Year: 2021, Volume and Issue: 6(22), P. 14399 - 14409

Published: May 26, 2021

As a key reactive oxygen species (ROS), hypochlorous acid (HClO) plays an important role in many physiological and pathological processes. The mitochondria-targeting probes for the highly sensitive detection of HClO are desirable. In present work, we designed synthesized original mitochondria-localizing turn-on fluorescent probe detecting HClO. 4-Aminonaphthalimide was employed as section, (2-aminoethyl)-thiourea unit utilized typical sensing unit, quaternized pyridinium moiety used mitochondria-targeted localization group. When absent, showed weak fluorescence. existence HClO, revealed blue Moreover, able to function broad pH scope. There excellent linearity between fluorescence emission intensity at 488 nm concentrations range 5.0 × 10–7 2.5 10–6 mol·L–1. Additionally, had almost no cell toxicity possessed capability. Furthermore, image mitochondria living PC-12 cells. above remarkable properties illustrated that determine

Language: Английский

Citations

28
Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes DOI

Maidileyvis C. Cabello,

Gen Chen, Michael J. Melville

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(16), P. 9225 - 9375

Published: Aug. 13, 2024

Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.

Language: Английский

Citations

4
A “double-locked” fluorescent probe for HClO/H2S detection DOI
Zhengkun Liu, Qianqian Wang, Wenjie Zhang

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155466 - 155466

Published: Jan. 1, 2025

Language: Английский

Citations

0
Side-chain-fixed homoadamantane-fused tetrahydroquinoxaline coumarin: a robust platform for highly photostable HClO probe development DOI
Qian Liu, Jingshuai Wang, Wenqiang Chen

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137705 - 137705

Published: March 1, 2025

Language: Английский

Citations

0
Non-Sequence-Activated “triple-key-and-dual-lock” ruthenium(II) complex as a dual-responsive luminescent probe for hypochlorous acid and formaldehyde: Enhancing accuracy of cancer diagnosis DOI
Junyu Ren,

Xiaona Gao,

Bo Song

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162680 - 162680

Published: April 1, 2025

Language: Английский

Citations

0
A novel dicyanisophorone-based colorimetric and ratiometric fluorescent probe for the detection of hypochlorite in the environment and living cells DOI
Li Liu,

Yixian Yang,

Yuanyuan Cui

et al.

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 208, P. 110879 - 110879

Published: Oct. 27, 2022

Language: Английский

Citations

18
A Near-Infrared Fluorescent Probe for Recognition of Hypochlorite Anions Based on Dicyanoisophorone Skeleton DOI Creative Commons

Chang-Xiang Liu,

Shu-Yuan Xiao,

Xiu-Lin Gong

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 402 - 402

Published: Jan. 3, 2023

A novel near-infrared (NIR) fluorescent probe (SWJT-9) was designed and synthesized for the detection of hypochlorite anion (ClO-) using a diaminomaleonitrile group as recognition site. SWJT-9 had large Stokes shift (237 nm) showed an excellent NIR fluorescence response to ClO- with color change under visible light. It low limit (24.7 nM), high selectivity, rapid (within 2 min) ClO-. The new mechanism on confirmed by 1H NMR, MS spectrum, density functional theory (DFT) calculations. In addition, successfully used detect in HeLa cells.

Language: Английский

Citations

10