Talanta, Journal Year: 2024, Volume and Issue: 284, P. 127196 - 127196
Published: Nov. 13, 2024
Language: Английский
Talanta, Journal Year: 2024, Volume and Issue: 284, P. 127196 - 127196
Published: Nov. 13, 2024
Language: Английский
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 431, P. 137432 - 137432
Published: Feb. 16, 2025
Language: Английский
Citations
1ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive decline, significantly impairing the daily life of elderly individuals. The low abundance blood-based biomarkers in AD necessitates higher analytical technique requirements. Herein, one novel iridium-based ECL self-enhanced nanoemitter (TPrA@Ir-SiO2) was unprecedentedly reported, it further used to construct an ultrasensitive magnetic immunosensor a multiple-signal amplification strategy unequally sensitively accurately detect biomarker (P-tau181) this work. initial signal accomplished via incorporating new efficient luminophore named Ir(mdq)2(acac) corresponding coreactant into silica nanoparticles successfully obtain TPrA@Ir-SiO2. In addition, specific high-affinity interactions between streptavidin biotin were subsequently employed facilitate amplification. Based on advantages itself streptavidin, proposed work exhibited remarkable sensitivity, covering wide linear range from 0.1 pg/mL μg/mL, achieved ultralow limit detection 68.58 fg/mL (S/N = 3), also outstanding recovery (98-104%) RSD (1.92-4.86%) serum samples spiking method. These results undoubtedly demonstrate potential nanoemitters combined with synergistic bearing streptavidin-biotin detecting biomarkers, providing accurate reliable solutions for early diagnosis monitoring AD, which would open avenue effectively reduce burden patients' families society future.
Language: Английский
Citations
0Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112493 - 112493
Published: Oct. 1, 2024
Language: Английский
Citations
2Talanta, Journal Year: 2024, Volume and Issue: 284, P. 127196 - 127196
Published: Nov. 13, 2024
Language: Английский
Citations
1