Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Nov. 27, 2023
As
one
of
most
common
and
severe
mental
disorders,
major
depressive
disorder
(MDD)
significantly
increases
the
risks
premature
death
other
medical
conditions
for
patients.
Neuroinflammation
is
abnormal
immune
response
in
brain,
its
correlation
with
MDD
receiving
increasing
attention.
has
been
reported
to
be
involved
through
distinct
neurobiological
mechanisms,
among
which
dysregulation
neurogenesis
dentate
gyrus
(DG)
hippocampus
(HPC)
The
DG
two
niches
adult
mammalian
neurotrophic
factors
are
fundamental
regulators
this
process.
cell
types
mediating
neuroinflammation
include
microglia,
astrocytes,
oligodendrocytes,
meningeal
leukocytes,
peripheral
cells
selectively
penetrate
blood-brain
barrier
infiltrate
into
inflammatory
regions.
This
review
summarizes
functions
affected
by
during
progression
corresponding
influences
on
memory
patients
model
animals.
Development,
Journal Year:
2019,
Volume and Issue:
146(4)
Published: Feb. 15, 2019
ABSTRACT
In
the
adult
rodent
brain,
neural
stem
cells
(NSCs)
persist
in
ventricular-subventricular
zone
(V-SVZ)
and
subgranular
(SGZ),
which
are
specialized
niches
young
neurons
for
olfactory
bulb
(OB)
hippocampus,
respectively,
generated.
Recent
studies
have
significantly
modified
earlier
views
on
mechanisms
of
NSC
self-renewal
neurogenesis
brain.
Here,
we
discuss
molecular
control,
heterogeneity,
regional
specification
cell
division
modes
V-SVZ
NSCs,
draw
comparisons
with
NSCs
SGZ.
We
highlight
how
regulated
by
local
signals
from
their
immediate
neighbors,
as
well
neurotransmitters
factors
that
secreted
distant
neurons,
choroid
plexus
vasculature.
also
review
recent
advances
single
RNA
analyses
reveal
complexity
neurogenesis.
These
findings
set
stage
a
better
understanding
neurogenesis,
process
one
day
may
inspire
new
approaches
to
brain
repair.
Stem Cell Reviews and Reports,
Journal Year:
2019,
Volume and Issue:
16(1), P. 3 - 32
Published: Nov. 23, 2019
Abstract
Over
the
past
20
years,
and
particularly
in
last
decade,
significant
developmental
milestones
have
driven
basic,
translational,
clinical
advances
field
of
stem
cell
regenerative
medicine.
In
this
article,
we
provide
a
systemic
overview
major
recent
discoveries
exciting
rapidly
developing
field.
We
begin
by
discussing
experimental
generation
differentiation
pluripotent
cells
(PSCs),
next
moving
to
maintenance
different
culture
types,
finishing
with
discussion
three-dimensional
(3D)
technology
future
applications.
Specifically,
highlight
following
crucial
domains:
1)
sources
cells;
2)
next-generation
vivo
direct
reprogramming
;
3)
types
derived
from
PSCs
influence
genetic
memory;
4)
induction
pluripotency
genomic
modifications;
5)
construction
vectors
factor
combinations;
6)
enhancing
small
molecules
signaling
pathways;
7)
RNA
signaling;
8)
enhancement
chemicals;
9)
stability
induced
(iPSCs);
10)
feeder-free
xenon-free
environments;
11)
biomaterial
applications
biology;
12)
technology;
13)
3D
bioprinting;
14)
downstream
applications;
15)
current
ethical
issues
This
review,
encompassing
fundamental
concepts
medicine,
is
intended
comprehensive
portrait
important
progress
research
development.
Innovative
technologies
real-world
are
emphasized
for
readers
interested
exciting,
promising,
challenging
those
seeking
guidance
planning
direction.
Molecular Neurodegeneration,
Journal Year:
2018,
Volume and Issue:
13(1)
Published: May 22, 2018
Neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD)
and
amyotrophic
lateral
sclerosis
(ALS),
affect
millions
of
people
every
year
so
far,
there
are
no
therapeutic
cures
available.
Even
though
animal
histological
models
have
been
great
aid
in
understanding
mechanisms
identifying
possible
strategies,
order
to
find
disease-modifying
solutions
is
still
a
critical
need
for
systems
that
can
provide
more
predictive
physiologically
relevant
results.
One
avenue
the
development
patient-derived
models,
e.g.
by
reprogramming
patient
somatic
cells
into
human
induced
pluripotent
stem
(hiPSCs),
which
then
be
differentiated
any
cell
type
modelling.
These
contain
key
genetic
information
from
donors,
therefore
enormous
potential
tools
investigation
pathological
underlying
phenotype,
progression,
well
drug
testing
platforms.
hiPSCs
widely
cultured
2D
systems,
but
mimic
brain
complexity,
3D
proposed
advanced
alternative.
This
review
will
focus
on
use
model
AD,
PD,
HD
ALS.
In
brief,
we
cover
available
cells,
types
culture
existing
neurodegenerative
obstacles
these
diseases
vitro,
current
perspectives
field.
Stem Cell Reports,
Journal Year:
2021,
Volume and Issue:
16(4), P. 681 - 693
Published: Feb. 26, 2021
Cognitive
deficits
associated
with
Alzheimer's
disease
(AD)
severely
impact
daily
life
for
the
millions
of
affected
individuals.
Progressive
memory
impairment
in
AD
patients
is
degeneration
hippocampus.
The
dentate
gyrus
hippocampus,
a
region
critical
learning
and
functions,
site
adult
neurogenesis
mammals.
Recent
evidence
humans
indicates
that
hippocampal
likely
persists
throughout
life,
but
declines
age
strikingly
impaired
AD.
Our
understanding
how
supports
healthy
adults
only
beginning
to
emerge.
extent
which
decreased
contributes
cognitive
decline
aging
remains
poorly
understood.
However,
studies
rodent
models
other
neurodegenerative
diseases
raise
possibility
targeting
may
ameliorate
dysfunction
Here,
we
review
recent
progress
impacted
context
