Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis DOI Creative Commons
Anbiao Wu, Jiyan Zhang

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior DOI
Yadong Li, Yan‐Jia Luo, Ze-Ka Chen

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(5), P. 630 - 645

Published: May 1, 2022

Language: Английский

Citations

104
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain DOI Creative Commons

Matthew T. Buckley,

Eric Sun, Benson M. George

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 3(1), P. 121 - 137

Published: Dec. 19, 2022

Abstract The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific rejuvenation. We generated transcriptomes from the subventricular zone neurogenic region 28 mice, tiling ages young old. trained single-cell-based regression models predict chronological age biological (neural stem proliferation capacity). These clocks are generalizable independent cohorts other regions brains, species. To determine if these could quantify transcriptomic rejuvenation, datasets two interventions—heterochronic parabiosis exercise. Aging revealed that heterochronic exercise reverse in regions, but different ways. This study represents first development high-resolution data demonstrates their application

Language: Английский

Citations

103
Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions DOI Creative Commons
Shaopeng Chi, Yaxiong Cui,

Haiping Wang

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(18), P. 2984 - 2999.e8

Published: Aug. 12, 2022

Language: Английский

Citations

98
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans DOI Open Access
Wei Wang, Mengdi Wang, Meng Yang

et al.

Cell Research, Journal Year: 2022, Volume and Issue: 32(8), P. 729 - 743

Published: June 24, 2022

Language: Английский

Citations

91
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis DOI Creative Commons
Anbiao Wu, Jiyan Zhang

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

Citations

84