Antioxidants,
Journal Year:
2021,
Volume and Issue:
11(1), P. 22 - 22
Published: Dec. 23, 2021
In
recent
years,
increasing
evidence
regarding
the
functional
importance
of
lipid
droplets
(LDs),
cytoplasmic
storage
organelles
in
central
nervous
system
(CNS),
has
emerged.
Although
not
abundantly
present
CNS
under
normal
conditions
adulthood,
LDs
accumulate
during
development
and
aging,
as
well
some
neurologic
disorders.
are
actively
involved
cellular
turnover
stress
response.
By
regulating
excess
fatty
acids,
cholesterol,
ceramides
addition
to
their
subsequent
release
response
cell
needs
and/or
environmental
stressors,
energy
production,
synthesis
membranes
signaling
molecules,
protection
cells
against
lipotoxicity
free
radicals.
Accumulation
appears
predominantly
neuroglia
(astrocytes,
microglia,
oligodendrocytes,
ependymal
cells),
which
provide
trophic,
metabolic,
immune
support
neuronal
networks.
Here
we
review
most
findings
on
characteristics
functions
neuroglia,
focusing
astrocytes,
key
homeostasis-providing
CNS.
We
discuss
molecular
mechanisms
affecting
LD
how
this
may
protect
neural
function.
also
highlight
role
(and
potential
contribution)
neuroglial
aging
Cells,
Journal Year:
2022,
Volume and Issue:
11(19), P. 3002 - 3002
Published: Sept. 26, 2022
Neural
stem
cells
(NSCs)
are
self-renewing,
multipotent
which
give
rise
to
all
components
of
the
central
nervous
system
(CNS)
during
embryogenesis,
but
also
activate
in
response
injury
and
disease
maintain
a
certain
level
neurogenic
activity
throughout
adulthood.
This
takes
place
specialized
regions
brain,
neurovascular
niches,
whose
main
role
is
control
behaviour
CNS.
In
adult
mammals,
two
“canonical”
niches
have
been
described:
The
subventricular
zone
(SVZ)
lateral
ventricles
subgranular
(SGZ)
dentate
gyrus.
review
discusses
our
current
understanding
neural
their
canonical
as
well
structure,
behaviours,
disease.
Neuron,
Journal Year:
2023,
Volume and Issue:
112(3), P. 342 - 361
Published: Nov. 14, 2023
Physical
forces
are
ubiquitous
in
biological
processes
across
scales
and
diverse
contexts.
This
review
highlights
the
significance
of
mechanical
nervous
system
development,
homeostasis,
disease.
We
provide
an
overview
signals
present
delve
into
mechanotransduction
mechanisms
translating
these
cues
biochemical
signals.
During
regulate
a
plethora
processes,
including
cell
proliferation,
differentiation,
migration,
network
formation,
cortex
folding.
Forces
then
continue
exerting
their
influence
on
physiological
such
as
neuronal
activity,
glial
function,
interplay
between
different
types.
Notably,
changes
tissue
mechanics
manifest
neurodegenerative
diseases
brain
tumors,
potentially
offering
new
diagnostic
therapeutic
target
opportunities.
Understanding
role
cellular
physiology
pathology
adds
facet
to
neurobiology,
shedding
light
many
that
remain
incompletely
understood.
PLoS Genetics,
Journal Year:
2018,
Volume and Issue:
14(11), P. e1007817 - e1007817
Published: Nov. 26, 2018
Cerebrospinal
fluid
flow
is
crucial
for
neurodevelopment
and
homeostasis
of
the
ventricular
system
brain,
with
localized
being
established
by
polarized
beating
ependymal
cell
(EC)
cilia.
Here,
we
report
a
homozygous
one
base-pair
deletion,
c.1193delT
(p.Leu398Glnfs*2),
in
Kinesin
Family
Member
6
(KIF6)
gene
child
displaying
neurodevelopmental
defects
intellectual
disability.
To
test
pathogenicity
this
novel
human
KIF6
mutation
engineered
an
analogous
C-terminal
truncating
mouse.
These
mutant
mice
display
severe,
postnatal-onset
hydrocephalus.
We
generated
Kif6-LacZ
transgenic
mouse
strain
expression
specifically
uniquely
within
cells
(ECs)
without
labeling
other
multiciliated
tissues.
Analysis
Kif6
scanning
electron
microscopy
(SEM)
immunofluorescence
(IF)
revealed
specific
formation
EC
cilia,
obvious
effect
cilia
Dilation
were
also
observed
adult
kif6
zebrafish.
Finally,
Kif6-GFP
localization
at
axoneme
basal
bodies
multi-ciliated
(MCCs)
mucociliary
Xenopus
epidermis.
Overall,
work
describes
first
clinically-defined
null
defines
as
conserved
mediator
neurological
development
role
ciliogenesis
vertebrates.
Development,
Journal Year:
2020,
Volume and Issue:
147(21)
Published: Oct. 6, 2020
ABSTRACT
The
vertebrate
body
plan
is
characterized
by
the
presence
of
a
segmented
spine
along
its
main
axis.
Here,
we
examine
current
understanding
how
axial
tissues
that
are
formed
during
embryonic
development
give
rise
to
adult
and
summarize
recent
advances
in
field,
largely
focused
on
studies
zebrafish,
with
comparisons
amniotes
where
appropriate.
We
discuss
work
illuminating
genetics
biological
mechanisms
mediating
extension
straightening
axis
development,
highlight
open
questions.
specifically
focus
processes
notochord
cerebrospinal
fluid
physiology,
defects
those
may
lead
scoliosis.
Nutrients,
Journal Year:
2020,
Volume and Issue:
12(4), P. 1195 - 1195
Published: April 24, 2020
Taste
reception
is
fundamental
for
the
proper
selection
of
food
and
beverages.
Among
several
chemicals
recognized
by
human
taste
system,
sodium
ions
(Na+)
are
particular
relevance.
Na+
represents
main
extracellular
cation
a
key
factor
in
many
physiological
processes.
elicits
specific
sensation,
called
salty
taste,
low-medium
concentrations
table
salt
(NaCl,
common
sodium-containing
chemical
we
use
to
season
foods)
perceived
as
pleasant
appetitive.
How
detect
this
foodstuffs
scarcely
understood.
In
animal
models,
such
mouse
rat,
epithelial
channel
(ENaC)
has
been
proposed
protein
recognizing
mediating
preference
responses
concentrations.
Here,
I
will
review
our
current
understanding
regarding
possible
involvement
ENaC
detection
system.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(28)
Published: July 2, 2024
The
brain’s
neuroreparative
capacity
after
injuries
such
as
ischemic
stroke
is
partly
contained
in
the
neurogenic
niches,
primarily
subventricular
zone
(SVZ),
which
lies
close
contact
with
cerebrospinal
fluid
(CSF)
produced
by
choroid
plexus
(ChP).
Despite
wide
range
of
their
proposed
functions,
ChP/CSF
remain
among
most
understudied
compartments
central
nervous
system
(CNS).
Here,
we
report
a
mouse
genetic
tool
(the
ROSA26iDTR
line)
for
noninvasive,
specific,
and
temporally
controllable
ablation
CSF-producing
ChP
epithelial
cells
to
assess
roles
CSF
brain
homeostasis
injury.
Using
this
model,
demonstrate
that
causes
rapid
permanent
volume
loss
both
aged
young
adult
brains,
accompanied
disruption
ependymal
cilia
bundles.
Surprisingly,
did
not
result
overt
neurological
deficits
at
1
mo
postablation.
However,
observed
pronounced
decrease
pool
SVZ
neuroblasts
(NBs)
following
ablation,
occurs
due
enhanced
migration
into
olfactory
bulb.
In
middle
cerebral
artery
occlusion
model
stroke,
NB
lesion
site
was
also
reduced
CSF-depleted
mice.
Thus,
our
study
establishes
an
important
role
regulating
regenerative
under
normal
conditions
stroke.