Pathophysiology of Lipid Droplets in Neuroglia DOI Creative Commons

Tina Smolič,

Robert Zorec, Nina Vardjan

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 22 - 22

Published: Dec. 23, 2021

In recent years, increasing evidence regarding the functional importance of lipid droplets (LDs), cytoplasmic storage organelles in central nervous system (CNS), has emerged. Although not abundantly present CNS under normal conditions adulthood, LDs accumulate during development and aging, as well some neurologic disorders. are actively involved cellular turnover stress response. By regulating excess fatty acids, cholesterol, ceramides addition to their subsequent release response cell needs and/or environmental stressors, energy production, synthesis membranes signaling molecules, protection cells against lipotoxicity free radicals. Accumulation appears predominantly neuroglia (astrocytes, microglia, oligodendrocytes, ependymal cells), which provide trophic, metabolic, immune support neuronal networks. Here we review most findings on characteristics functions neuroglia, focusing astrocytes, key homeostasis-providing CNS. We discuss molecular mechanisms affecting LD how this may protect neural function. also highlight role (and potential contribution) neuroglial aging

Language: Английский

Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics DOI Creative Commons

Archana Gengatharan,

Sarah Malvaut, Alina Marymonchyk

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(3), P. 709 - 722.e13

Published: Jan. 21, 2021

Language: Английский

Citations

75
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self DOI
Michael Levin

Progress in Biophysics and Molecular Biology, Journal Year: 2021, Volume and Issue: 165, P. 102 - 113

Published: May 4, 2021

Language: Английский

Citations

74
Current Understanding of the Neural Stem Cell Niches DOI Creative Commons
Vicente Llorente,

Pedro Velarde,

Manuel Desco

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3002 - 3002

Published: Sept. 26, 2022

Neural stem cells (NSCs) are self-renewing, multipotent which give rise to all components of the central nervous system (CNS) during embryogenesis, but also activate in response injury and disease maintain a certain level neurogenic activity throughout adulthood. This takes place specialized regions brain, neurovascular niches, whose main role is control behaviour CNS. In adult mammals, two “canonical” niches have been described: The subventricular zone (SVZ) lateral ventricles subgranular (SGZ) dentate gyrus. review discusses our current understanding neural their canonical as well structure, behaviours, disease.

Language: Английский

Citations

40
Mechanics in the nervous system: From development to disease DOI Creative Commons
Eva K. Pillai, Kristian Franze

Neuron, Journal Year: 2023, Volume and Issue: 112(3), P. 342 - 361

Published: Nov. 14, 2023

Physical forces are ubiquitous in biological processes across scales and diverse contexts. This review highlights the significance of mechanical nervous system development, homeostasis, disease. We provide an overview signals present delve into mechanotransduction mechanisms translating these cues biochemical signals. During regulate a plethora processes, including cell proliferation, differentiation, migration, network formation, cortex folding. Forces then continue exerting their influence on physiological such as neuronal activity, glial function, interplay between different types. Notably, changes tissue mechanics manifest neurodegenerative diseases brain tumors, potentially offering new diagnostic therapeutic target opportunities. Understanding role cellular physiology pathology adds facet to neurobiology, shedding light many that remain incompletely understood.

Language: Английский

Citations

40
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions DOI
Alina Marymonchyk,

Raquel Rodríguez-Aller,

Ashleigh Willis

et al.

Cell stem cell, Journal Year: 2025, Volume and Issue: 32(3), P. 445 - 462.e9

Published: Feb. 6, 2025

Language: Английский

Citations

1
Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain DOI Open Access

Tjaša Lepko,

Melanie Pusch,

Tamara Müller

et al.

The EMBO Journal, Journal Year: 2019, Volume and Issue: 38(17)

Published: July 15, 2019

Language: Английский

Citations

67
Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development DOI Creative Commons
Mia J. Konjikusic, Patra Yeetong, Curtis W. Boswell

et al.

PLoS Genetics, Journal Year: 2018, Volume and Issue: 14(11), P. e1007817 - e1007817

Published: Nov. 26, 2018

Cerebrospinal fluid flow is crucial for neurodevelopment and homeostasis of the ventricular system brain, with localized being established by polarized beating ependymal cell (EC) cilia. Here, we report a homozygous one base-pair deletion, c.1193delT (p.Leu398Glnfs*2), in Kinesin Family Member 6 (KIF6) gene child displaying neurodevelopmental defects intellectual disability. To test pathogenicity this novel human KIF6 mutation engineered an analogous C-terminal truncating mouse. These mutant mice display severe, postnatal-onset hydrocephalus. We generated Kif6-LacZ transgenic mouse strain expression specifically uniquely within cells (ECs) without labeling other multiciliated tissues. Analysis Kif6 scanning electron microscopy (SEM) immunofluorescence (IF) revealed specific formation EC cilia, obvious effect cilia Dilation were also observed adult kif6 zebrafish. Finally, Kif6-GFP localization at axoneme basal bodies multi-ciliated (MCCs) mucociliary Xenopus epidermis. Overall, work describes first clinically-defined null defines as conserved mediator neurological development role ciliogenesis vertebrates.

Language: Английский

Citations

60
Development of a straight vertebrate body axis DOI Open Access
Michel Bagnat, Ryan S. Gray

Development, Journal Year: 2020, Volume and Issue: 147(21)

Published: Oct. 6, 2020

ABSTRACT The vertebrate body plan is characterized by the presence of a segmented spine along its main axis. Here, we examine current understanding how axial tissues that are formed during embryonic development give rise to adult and summarize recent advances in field, largely focused on studies zebrafish, with comparisons amniotes where appropriate. We discuss work illuminating genetics biological mechanisms mediating extension straightening axis development, highlight open questions. specifically focus processes notochord cerebrospinal fluid physiology, defects those may lead scoliosis.

Language: Английский

Citations

57
Does ENaC Work as Sodium Taste Receptor in Humans? DOI Open Access
Albertino Bigiani

Nutrients, Journal Year: 2020, Volume and Issue: 12(4), P. 1195 - 1195

Published: April 24, 2020

Taste reception is fundamental for the proper selection of food and beverages. Among several chemicals recognized by human taste system, sodium ions (Na+) are particular relevance. Na+ represents main extracellular cation a key factor in many physiological processes. elicits specific sensation, called salty taste, low-medium concentrations table salt (NaCl, common sodium-containing chemical we use to season foods) perceived as pleasant appetitive. How detect this foodstuffs scarcely understood. In animal models, such mouse rat, epithelial channel (ENaC) has been proposed protein recognizing mediating preference responses concentrations. Here, I will review our current understanding regarding possible involvement ENaC detection system.

Language: Английский

Citations

51
The choroid plexus maintains adult brain ventricles and subventricular zone neuroblast pool, which facilitates poststroke neurogenesis DOI Creative Commons

Александр Таранов,

Alicia Bedolla, Eri Iwasawa

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(28)

Published: July 2, 2024

The brain’s neuroreparative capacity after injuries such as ischemic stroke is partly contained in the neurogenic niches, primarily subventricular zone (SVZ), which lies close contact with cerebrospinal fluid (CSF) produced by choroid plexus (ChP). Despite wide range of their proposed functions, ChP/CSF remain among most understudied compartments central nervous system (CNS). Here, we report a mouse genetic tool (the ROSA26iDTR line) for noninvasive, specific, and temporally controllable ablation CSF-producing ChP epithelial cells to assess roles CSF brain homeostasis injury. Using this model, demonstrate that causes rapid permanent volume loss both aged young adult brains, accompanied disruption ependymal cilia bundles. Surprisingly, did not result overt neurological deficits at 1 mo postablation. However, observed pronounced decrease pool SVZ neuroblasts (NBs) following ablation, occurs due enhanced migration into olfactory bulb. In middle cerebral artery occlusion model stroke, NB lesion site was also reduced CSF-depleted mice. Thus, our study establishes an important role regulating regenerative under normal conditions stroke.

Language: Английский

Citations

8