Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury

Cell Reports, Journal Year: 2021, Volume and Issue: 35(6), P. 109092 - 109092

Published: May 1, 2021

Alveolar epithelial type 2 (AT2) cells integrate signals from multiple molecular pathways to proliferate and differentiate drive regeneration of the lung alveolus. Utilizing in vivo genetic ex organoid models, we investigated role Fgfr2 signaling AT2 across lifespan during adult after influenza infection. We show that, although dispensable for homeostasis, restricts cell fate postnatal development. Using an unbiased computational imaging approach, demonstrate that promotes proliferation restrains differentiation actively regenerating areas injury. Organoid assays reveal Fgfr2-deficient remain competent respond parallel proliferative inputs. Moreover, blockade cytokinesis demonstrates division are uncoupled alveolar regeneration. These data maintains fate, balancing

Language: Английский

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SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 29(7), P. 1395 - 1408

Published: Jan. 12, 2022

Language: Английский

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Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract

Journal of Virology, Journal Year: 2021, Volume and Issue: 95(14)

Published: April 26, 2021

The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute syndrome coronavirus 2 (SARS-CoV-2). While imbalanced innate immune response of end-stage disease 2019 (COVID-19) has been extensively studied, earliest stages SARS-CoV-2 infection at mucosal have remained unexplored. Here, we employed and influenza virus in native multi-cell-type human turbinate lung tissues

Language: Английский

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Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(9), P. 953 - 966

Published: Sept. 1, 2021

Language: Английский

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Lung organoids, useful tools for investigating epithelial repair after lung injury

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 30, 2021

Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung can be generated. applied widely development, disease modelling, regenerative medicine, other multiple aspects. Various human pulmonary diseases caused by several factors induced lead to different degrees epithelial injury. Epithelial repair involves the participation signalling pathways. Lung organoids provide an excellent platform model injury lungs. Here, we review recent methods cultivating applications after injury, understanding mechanisms investigated using organoids. By discover regulatory related epithelia. This strategy could new insights for more effective management development drugs.

Language: Английский

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