Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(31)
Published: June 20, 2023
Abstract
MicroRNAs
(miRNAs)
have
emerged
as
promising
diagnostic
biomarkers
and
therapeutic
targets
in
various
diseases.
However,
there
is
currently
a
lack
of
molecular
strategies
that
can
effectively
use
disease‐associated
extracellular
miRNAs
input
signals
to
drive
functions.
Herein,
we
present
modular
programmable
miRNA‐responsive
chimeric
DNA
receptor
(miRNA‐CDR)
capable
biomarker‐driven
therapy.
By
grafting
nanodevice
on
natural
membrane
via
aptamer
anchoring,
miRNA‐CDR
sense
miRNA
levels
autonomously
induce
dimerization‐mediated
activation
the
complementary‐mediated
strand
displacement
reaction‐induced
dynamic
assembly.
The
sequence
programmability
allows
it
respond
user‐defined
with
tunable
sensitivity.
Moreover,
versatile
customizable
reprogram
desirable
signaling
output
adapting
designated
receptor,
such
MET
FGFR1.
Using
mouse
model
drug‐induced
acute
liver
injury
(DILI),
demonstrate
functionality
designer
rewiring
recognition
DILI‐elevated
miR‐122
promote
hepatocytes
for
situ
repair
function
restoration.
Our
synthetic
platform
provides
novel
device
enabling
cellular
response,
potentially
paving
way
improving
precision
cell
therapy
regenerative
medicine.
Polymer Chemistry,
Journal Year:
2024,
Volume and Issue:
15(34), P. 3436 - 3468
Published: Jan. 1, 2024
Lipid–polymer
hybrid
nanoparticles
are
rapidly
emerging
as
a
major
class
of
efficient
delivery
systems
for
biomedical
applications.
This
review
showcases
and
discusses
the
designs
advances
lipid–polymer
hybrids
genome
editing
strategies.
Medical Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Current
two-dimensional
(2D)
cell
models
for
effective
drug
screening
suffer
from
significant
limitations
imposed
by
the
lack
of
realism
in
physiological
environment.
Three-dimensional
(3D)
organoids
hold
immense
potential
mimicking
key
functions
human
organs
overcoming
traditional
2D
models.
However,
current
techniques
preparation
3D
had
reproducibility,
scalability,
and
ability
to
closely
replicate
complex
microenvironment
found
vivo
.
Additionally,
culture
systems
often
involve
lengthy
labor-intensive
processes
that
hinder
high-throughput
applications
necessary
a
large-scale
screening.
Advancements
bioprinting
technologies
offer
promising
solutions
these
challenges
enabling
precise
spatial
control
over
placement
material
composition,
thereby
facilitating
creation
more
physiologically
relevant
than
techniques.
This
review
provides
comprehensive
summary
recent
advances
creating
models,
which
begins
with
an
introduction
different
types
(especially
focus
on
volumetric
(VBP)
technique),
followed
overview
bioinks
utilized
bioprinting.
Moreover,
we
also
introduce
disease
efficiency
evaluation
regenerative
medicine.
Finally,
possible
strategies
development
clinical
translation
are
concluded.
Artificial Organs,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
A
recent
advancement
in
the
field
of
organogensis
involves
self-assembly
embryoids
using
strategically
positioned
organizer
cells.
This
offers
a
reliable
and
self-programmable
model
for
organoid
development.
Trends in biotechnology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Diabetes
is
a
complex
disease
affecting
over
500
million
people
worldwide.
Traditional
approaches,
such
as
insulin
delivery,
are
mainstay
treatments,
but
do
not
cure
the
disease.
Recent
advances
in
biofabrication
and
synthetic
biology
offer
new
hope
for
development
of
tissue
constructs
recapitulating
salient
organ
functions.
Here,
we
discuss
recent
progress
bioprinting
functional
endocrine
pancreas,
ranging
from
cell
sources
to
main
biomaterials.
We
review
innovative
areas
this
field,
with
particular
focus
on
convergence
engineering
bioprinting,
which
opens
avenues
developing
advanced
vitro
models
regenerative,
transplantable
grafts,
potential
provide
independence
exogenous
administration.
EMBO Reports,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Abstract
Morphogens,
locally
produced
signaling
molecules,
form
a
concentration
gradient
to
guide
tissue
patterning.
Tissue
patterns
emerge
as
collaboration
between
morphogen
diffusion
and
responsive
cell
behaviors,
but
the
mechanisms
through
which
diffusing
morphogens
define
precise
spatial
amidst
biological
fluctuations
remain
unclear.
To
investigate
how
cells
respond
proteins
generate
patterns,
we
develop
SYMPLE3D,
3D
culture
platform.
By
engineering
gene
expression
artificial
morphogens,
observe
that
coupling
signals
with
cadherin-based
adhesion
is
sufficient
convert
into
distinct
domains.
Morphogen-induced
cadherins
gather
activated
single
domain,
removing
ectopically
cells.
In
addition,
reveal
switch-like
induction
of
cadherin-mediated
compaction
mixing,
homogenizing
within
uniformly
domain
sharp
boundary.
These
findings
highlight
cooperation
gradients
in
robust
patterning
introduce
novel
method
for
new
domains
organoids.
