Microglia mediated by SuM-ABN axis restores cognitive dysfunction and postones AD progression DOI Creative Commons
Xinyi Zhang

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 166, P. 01004 - 01004

Published: Jan. 1, 2025

Microglia, a kind of highly dynamic central neural system immunity cells, transform phenotype based on diverse stimuli, playing vital roles in adult neurogenesis and synaptic connection for affecting AD progression. Particularly, microglia are mainly composed anti-inflammatory types mild patients, which offer immune surveillance to clear away amyloid beta plaques facilitate neurogenesis. However, these into pro-inflammatory alike accelerate the deterioration disease if exposed chronic but slow-level stimulation. Thus, how control microgial prototype becomes promising therapeutic direction. It has been found that adult-born neurons activation mediated by SuM stimulation early mice could promote phagocytosis, improving cognitive functions. In this paper, I focus whether AHN increasing BDNF release after SuM-ABN ABN-stimulated or maintain prevent improper cut, leading enhancement.

Language: Английский

Implantable hydrogels as pioneering materials for next-generation brain–computer interfaces DOI
Wasid Ullah Khan,

Zhenzhen Shen,

Samuel M. Mugo

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Hydrogels are emerging as promising candidates for brain–computer interfaces. This review highlights the current advancements in implantable hydrogel electrodes neural signal recording, neuromodulation, and brain disorder treatment.

Language: Английский

Citations

3
Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment DOI
Yu‐Yuan Huang,

Yi‐Han Gan,

Yang Liu

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(11), P. 992 - 1005

Published: Oct. 20, 2023

Language: Английский

Citations

37
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology DOI Creative Commons

Peibin Zou,

Chongyun Wu,

Timon Cheng‐Yi Liu

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Nov. 14, 2023

Abstract Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring contributing to the integrity of blood–brain barrier (BBB). However, under pathological circumstances Alzheimer’s disease (AD), brain’s microenvironment undergoes detrimental changes that significantly impact OPCs their functions. Starting OPC functions, we delve into transformation myelin-producing oligodendrocytes, intricate signaling interactions other central nervous system (CNS), fascinating process which influences function affects CNS homeostasis. Moreover, discuss essential role BBB highlight critical contribution forming CNS-protective barriers. In context AD, deterioration local brain is discussed, mainly focusing on neuroinflammation, oxidative stress, accumulation toxic proteins. The disturb delicate balance brain, impacting regenerative capacity compromising integrity. Under conditions, experience significant alterations migration proliferation, leading impaired differentiation a reduced ability produce mature oligodendrocytes. degeneration become increasingly active progressive neurodegeneration. Finally, summarize current therapeutic approaches targeting AD. Strategies revitalize senescence, modulate pathways enhance differentiation, explore potential avenues are promising alleviating AD function. conclusion, this review highlights indispensable involvement pathogenesis interplay between underscores complexity neurodegenerative diseases. Insights from studying conditions provide foundation for innovative strategies fostering Future research will advance our understanding management diseases, ultimately offering hope effective treatments improved quality life those affected by related disorders.

Language: Английский

Citations

28
Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain DOI Creative Commons
Yadong Li, Yan‐Jia Luo,

Wei-Kun Su

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(8), P. 1328 - 1341.e4

Published: Feb. 13, 2024

Chronic pain often leads to the development of sleep disturbances. However, precise neural circuit mechanisms responsible for disorders in chronic have remained largely unknown. Here, we present compelling evidence that hyperactivity pyramidal neurons (PNs) anterior cingulate cortex (ACC) drives insomnia a mouse model nerve-injury-induced pain. After nerve injury, ACC PNs displayed spontaneous selectively periods insomnia. We then show were both necessary developing chronic-pain-induced and sufficient mimic loss naive mice. Importantly, combining optogenetics electrophysiological recordings, found projection dorsal medial striatum (DMS) underlies through enhanced activity plasticity ACC-DMS dopamine D1R neuron synapses. Our findings shed light on pivotal role disorders.

Language: Английский

Citations

16
Neural stem cell metabolism revisited: a critical role for mitochondria DOI Open Access
Valentina Scandella, Francesco Petrelli, Darcie L. Moore

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(8), P. 446 - 461

Published: June 26, 2023

Language: Английский

Citations

23
Hypothalamic Supramammillary Control of Cognition and Motivation DOI Creative Commons
Andrew J. Kesner,

Marjan Mozaffarilegha,

Keerthi Thirtamara Rajamani

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(45), P. 7538 - 7546

Published: Nov. 8, 2023

The supramammillary nucleus (SuM) is a small region in the ventromedial posterior hypothalamus. SuM has been relatively understudied with much of prior focus being on its connection septo-hippocampal circuitry. Thus, most studies conducted until 21st century examined role hippocampal processes, such as theta rhythm and learning/memory. In recent years, “rediscovered” crucial hub for several behavioral cognitive including reward-seeking, exploration, social memory. Additionally, it shown to play significant roles plasticity adult neurogenesis. This review highlights findings from using cutting-edge systems neuroscience tools that have shed light these fascinating SuM.

Language: Английский

Citations

19
Lancao decoction alleviates Alzheimer’s disease: depending on activating CaMKII to protect neuronal refunction by reducing β-amyloid in the hippocampus DOI
Lei Wu, Yan Sun, Lingang Zhao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119619 - 119619

Published: March 1, 2025

Language: Английский

Citations

1
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology DOI Creative Commons
Ling Xie, Ryan N. Sheehy, Adil Muneer

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 6, 2025

Language: Английский

Citations

1
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease DOI Creative Commons
Tohid Siddiqui, Mehmet İlyas Coşacak,

Stanislava Popova

et al.

npj Regenerative Medicine, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 10, 2023

Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that induces astroglial reactivity at the expense of pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology. However, molecular mechanisms promoting fate despite AD pathology are unknown. In this study, we used APP/PS1dE9 mouse model induced Nerve growth factor receptor (Ngfr) expression hippocampus. Ngfr, which promotes neurogenic astroglia during amyloid pathology-induced neuroregeneration zebrafish brain, stimulated proliferative outcomes. Histological analyses changes proliferation neurogenesis, single-cell transcriptomics, spatial proteomics, functional knockdown studies showed Ngfr reactive astrocyte marker Lipocalin-2 (Lcn2), found was sufficient to reduce astroglia. Anti-neurogenic effects Lcn2 mediated by Slc22a17, blockage recapitulated pro-neurogenicity Ngfr. Long-term plaques Tau phosphorylation. Postmortem human hippocampi 3D cultures elevated LCN2 levels correlate with gliosis neurogenesis. Comparing transcriptional mouse, zebrafish, brains cell intrinsic differential gene weighted co-expression networks revealed common altered downstream effectors NGFR signaling, such as PFKP, can enhance vitro when blocked. Our study suggests non-neurogenic be coaxed a alleviated We suggest enhancing may have therapeutic ramifications AD.

Language: Английский

Citations

16
Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications DOI Creative Commons
Siyou Tan, Wenyan Chen,

Gaoyin Kong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Nov. 29, 2023

Cognitive impairments, such as learning and memory deficits, may occur in susceptible populations including the elderly patients who are chronically ill or have experienced stressful events, surgery, infection, trauma. Accumulating lines of evidence suggested that peripheral inflammation featured by recruitment immune cells release pro-inflammatory cytokines be activated during aging these conditions, participating system-brain communication. Lots progress has been achieved deciphering core bridging mechanism connecting cognitive which helpful developing early diagnosis, prognosis evaluation, prevention methods based on blood circulation system sampling intervention. In this review, we summarized evolving prevalence inflammation-associated neurocognitive impairments discussed research advances underlying mechanisms. We also highlighted treatment strategies against dysfunction.

Language: Английский

Citations

16