The immune-inflammatory responses on the hypothalamic-pituitary-adrenal axis and the neurovascular unit in perioperative neurocognitive disorder

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115146 - 115146

Published: Jan. 11, 2025

Language: Английский

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IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488

Published: May 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Language: Английский

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Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: March 26, 2024

With the aging of population, health elderly has become increasingly important. Postoperative cognitive dysfunction (POCD) is a common neurological complication in patients following general anesthesia or surgery. It characterized by decline that may persist for weeks, months, even longer. Electroacupuncture (EA), novel therapy combines physical nerve stimulation with acupuncture treatment from traditional Chinese medicine, holds potential as therapeutic intervention preventing and treating POCD, particularly patients. Although beneficial effects EA on POCD have been explored preclinical clinical studies, reliability limited methodological shortcomings, underlying mechanisms remain largely unexplored. Therefore, we synthesized existing evidence proposed biological neuroinflammation, oxidative stress, autophagy, microbiota-gut-brain axis, epigenetic modification. This review summarizes recent advances provides theoretical foundation, explores molecular prevention offers basis conducting relevant trials.

Language: Английский

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Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 6, 2024

Background Delirium seriously affects the prognosis of patients and greatly reduces ability to work live. Peripheral inflammatory events may contribute development delirium, mechanism which is still unclear. There a lack effective diagnostic treatments for delirium in clinical practice. The study aims investigate alterations peripheral immune cell subsets under stress explore causal associations with delirium. Methods Single-cell transcriptional sequencing data human blood mononuclear cells (PBMC) before after lipopolysaccharide (LPS) intervention were processed by Seurat package R software. PBMC cellular markers defined downscaling clustering Harmony algorithm identify characteristic context stress. Subsequently, two-sample Mendelian randomization (MR) was used these inflammation-related their molecular phenotypes Based on publicly available genetic data, incorporated 70 PBMC-associated traits, including 8 types circulating cells, 33 B phenotypes, 13 T subsets, 16 cell-associated cytokines. results also validated robustness, heterogeneity, horizontal pleiotropy. Results Under LPS-induced stress, monocytes, dendritic showed significant activation quantitative changes. Of these, only lymphocyte counts causally associated risk. This risk link seen TNF pathway. Further studies revealed that this association be related unswitched memory CD27 expressed cells. Annotation screened SNPs polymorphisms CD40 annotated rs25680 rs9883798, respectively. functions key genes regulation responses, differentiation, proliferation, intercellular interactions. Conclusion present potential possibility cell, subset, TNF-related molecules involved due inflammation, can provide clues further investigation prevention treatment strategies.

Language: Английский

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The activation of cGAS‐STING pathway causes abnormal uterine receptivity in aged mice

Aging Cell, Journal Year: 2024, Volume and Issue: 23(11)

Published: Aug. 7, 2024

Maternal age is one of the most important factors affecting success maternal pregnancy. Uterine aging leading cause pregnancy failure in older women. However, how uterine affects receptivity and decidualization unclear. In this study, naturally aged one-year-old female mice were used to investigate effects on embryo implantation during early our we found abnormal mice. Aged mouse uterus indicates a decrease nuclear LAMIN A, an increase PRELAMIN A PROGERIN. uterus, double-stranded DNA (dsDNA) cytoplasmic fraction significantly increased. PROGERIN overexpression epithelial cells organoids leads leakage impaired receptivity. DNase I, II, TREX1 are obviously reduced uterus. Treatments with foreign or STING agonist downregulate markers activate cGAS-STING pathway. estrogen (E

Language: Английский

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Distinct Morning and Evening Fatigue Profiles in Patients With Gynecologic Cancers Receiving Chemotherapy

Oncology nursing forum, Journal Year: 2025, Volume and Issue: 52(2), P. E35 - E57

Published: Feb. 18, 2025

To identify distinct morning and evening fatigue profiles in patients with gynecologic cancers evaluate for differences demographic clinical characteristics, common symptoms, quality-of-life outcomes. Outpatients (N = 233) were recruited before their second or third cycles of chemotherapy at four cancer centers San Francisco Bay New York. The Lee Fatigue Scale was completed six times over two the evening. Latent profile analysis used to profiles. Four classes identified. Common risk factors included younger age, higher body mass index, lower functional status, comorbidity burden. Patients worst reported levels anxiety, depression, sleep disturbance; energy cognitive function; poorer quality life. Clinicians can use this information higher-risk develop individualized interventions fatigue.

Language: Английский

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Microbiome functional gene pathways predict cognitive performance in older adults with Alzheimers disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

ABSTRACT Disturbances in the gut microbiome is increasing correlated with neurodegenerative disorders, including Alzheimer’s Disease. The may fact influence disease pathology AD by triggering or potentiating systemic and neuroinflammation, thereby driving along “microbiota-gut-brain-axis”. Currently, drivers of cognitive decline symptomatic progression remain unknown understudied. Changes composition offer clues to potential physiologic neuropathologic changes that contribute decline. Here, we recruited a cohort 260 older adults (age 60+) living community followed them over time, tracking objective measures cognition, clinical information, microbiomes. Subjects were classified as healthy controls having mild impairment based on performance. Those diagnosis Diseases confirmed using serum biomarkers. Using metagenomic sequencing, found relative species abundances well cognition status (MCI AD). Furthermore, gene pathways analyses suggest certain microbial metabolic either be maintaining function. Specifically, genes involved urea cycle production methionine cysteine predicted worse Our study suggests predict

Language: Английский

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Dynamic changes in peripheral inflammation as a risk factor for perioperative sleep disturbances in elderly patients undergoing laparoscopic hepatobiliary surgery

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Elderly surgical patients are at high risk of perioperative sleep disturbances (PSD), and the underlying pathogenic mechanisms remain unclear. The relationship between peripheral inflammatory status PSD pathogenesis currently lacks substantial clinical evidence. This study aims to evaluate association inflammation indicators in elderly undergoing laparoscopic hepatobiliary surgery, analyze dynamic changes throughout period. Using retrospective data, this compares markers (NLR, MLR, PLR, SII, IL-6, IL-10) with vs. those normal patterns before after surgery. Receiver operating characteristic (ROC) curves were employed discriminative power these for PSD. Logistic regression models assess associations Dynamic compared on day surgery ended, 1 post-surgery sleep, exploring potential correlations pathogenesis. ultimately included data from 156 patients. Findings indicated that elevated NLR SII levels alongside decreased plasma IL-10 post-surgery, associated a higher incidence Peripheral not significantly predictive post-PSD. Multivariable logistic analyses identified NLR, as independent predictors pre-PSD, while remained independently during period These findings may support early identification screening high-risk patients, providing new insights into

Language: Английский

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A second act for spironolactone: cognitive benefits in renal dysfunction – a critical review

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(5)

Published: April 29, 2025

Language: Английский

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Association between dietary insulin index and risk of depression, anxiety, and sleep disturbance in a group of Iranian physically active adults

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Objectives Anxiety and depression are among the most prevalent mental health disorders worldwide (In Iran, approximately 21% of adults). Athletes often consume carbohydrate-rich diets to boost their performance, but this diet might potentially influenced mood through insulin secretion increases in serotonin melatonin. This study investigates association between Dietary Insulin Index (DII) risk depression, anxiety, sleep physically active adults. Methods cross-sectional included 690 bodybuilding athletes (ages 18–50, BMI 20–30) from Kashan, Iran. Demographic, medical, data participants were collected using Beck Depression Inventory II (BDI-II), (BAI), Pittsburgh Sleep Quality (PSQI). intake was assessed via a 147-item Food Frequency Questionnaire. The DII Load (DIL) calculated by multiplying index each food item its energy content consumption frequency, summing across all items. Results In fully adjusted model, there no significant odds (OR: 0.80; 95% CI: 0.48, 1.33) or anxiety 1.14; 0.61, 2.12). However, individuals highest tertile had higher as compared those at lowest 1.51; 1.04, 2.22; p for trend = 0.03). Conclusions A direct found disorders, with depression. Further studies needed explore these findings various physical activity levels.

Language: Английский

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